Susceptibility of a new world monkey (Aotus trivirgatus) to an old world simian malarial parasite (Plasmodium knowlesi)

Siddiqui, Wasim A.; Schnell, Jerome V.; Richmond-Crum, Suzanne M.

doi:10.1016/0035-9203(74)90154-0

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…4 ). Thus, it is likely that P. knowlesi is capable of invading its macaque host red blood cells via a DARC-independent pathway, confirming previous observations 21 22 23 24 .…”

Section: Discussionsupporting

confidence: 87%

Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human

Amir

Russell

Liew

et al. 2016

Sci Rep

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Plasmodium knowlesi is extensively used as an important malaria model and is now recognized as an important cause of human malaria in Malaysia. The strains of P. knowlesi currently used for research were isolated many decades ago, raising concerns that they might no longer be representative of contemporary parasite populations. We derived a new P. knowlesi line (University Malaya line, UM01), from a patient admitted in Kuala Lumpur, Malaysia, and compared it with a human-adapted laboratory line (A1-H.1) derived from the P. knowlesi H strain. The UM01 and A1-H.1 lines readily invade human and macaque (Macaca fascicularis) normocytes with a preference for reticulocytes. Whereas invasion of human red blood cells was dependent on the presence of the Duffy antigen/receptor for chemokines (DARC) for both parasite lines, this was not the case for macaque red blood cells. Nonetheless, differences in invasion efficiency, gametocyte production and the length of the asexual cycle were noted between the two lines. It would be judicious to isolate and characterise numerous P. knowlesi lines for use in future experimental investigations of this zoonotic species.

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“…4 ). Thus, it is likely that P. knowlesi is capable of invading its macaque host red blood cells via a DARC-independent pathway, confirming previous observations 21 22 23 24 .…”

Section: Discussionsupporting

confidence: 87%

Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human

Amir

Russell

Liew

et al. 2016

Sci Rep

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show abstract

“…This is not likely to occur with infections of P. knowlesi induced by inoculation with fresh blood. However, when the blood has been kept in liquid N2 storage, spontaneous recovery occasionally occurs (10).…”

mentioning

confidence: 99%

Long-term studies on rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi

Cabrera¹,

Barr²,

Silverman³

1977

Infect Immun

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Studies carried out on four rhesus monkeys (Macaca mulatta) that had been vaccinated against Plasmodium knowlesi show that the immunized animals were protected against a challenge with a heterologous strain of P. knowlesi. This protection was shown to be present even 4 years after the immunization schedule has been completed. The effect could not be attributed toprevious infections with the parasite, since four control rhesus monkeys that had recovered from one to four challenges with P. knowlesi died when exposed to the heterologous strain. Data obtained from the lymphocyte transformation test and the radioimmunoassay are also presented.

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Infection of the squirrel monkey, Saimiri sciureus, with Plasmodium knowlesi

Collins¹,

Contacos²,

Chin³

1978

Transactions of the Royal Society of Tropical Medicine and Hygi

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Susceptibility of a new world monkey (Aotus trivirgatus) to an old world simian malarial parasite (Plasmodium knowlesi)

Cited by 7 publications

References 10 publications

Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human

Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human

Long-term studies on rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi

Infection of the squirrel monkey, Saimiri sciureus, with Plasmodium knowlesi

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