Susceptibilidad in vitro a anidulafungina en 100 cepas de especies de Candida aisladas previo a la introducción de esta equinocandina en Chile

O, Claudio Alburquenque; A, Viviana Silva; G, Milenko Fuentes; C, Cecilia Tapia; Silva, Víctor

doi:10.4067/s0716-10182011000600001

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…The epidemiology of these candidiases is very dynamic as the prevalence of Candida species varies in different geographical areas, kinds of patients and hospital types [ 3 ]. One of the major problems of these diseases is the high frequency of non- albicans Candida species that present intrinsic or secondary resistance to various antifungals, narrowing medical treatment alternatives and increasing the chances of morbidity and mortality [ 4 ]. Today, there is an expected global epidemic of C. auris in health care settings with high mortality and multidrug resistance characteristics, with 93% of isolates resistant to fluconzazole, 35% to amphotericin B, 7% to echinocandin, 42% to two or more antifungal classes and 4% to all antifungal classes.…”

Section: Introductionmentioning

confidence: 99%

Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients

Marin

Bart

Cortez

et al. 2022

IJMS

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Drimys winteri J.R. (Winteraceae) produce drimane sesquiterpenoids with activity against Candida yeast. In this work, drimenol, polygodial (1), isotadeonal (2), and a new drimane α,β-unsaturated 1,4-dialdehyde, named winterdial (4), were purified from barks of D. winteri. The oxidation of drimenol produced the monoaldehyde drimenal (3). These four aldehyde sesquiterpenoids were evaluated against six Candida species isolated from candidemia patients in Chilean hospitals. Results showed that 1 displays fungistatic activity against all yeasts (3.75 to 15.0 µg/mL), but irritant effects on eyes and skin, whereas its non-pungent epimer 2 has fungistatic and fungicide activities at 1.9 and 15.0 µg/mL, respectively. On the other hand, compounds 3 and 4 were less active. Molecular dynamics simulations suggested that compounds 1–4 are capable of binding to the catalytic pocket of lanosterol 14-alpha demethylase with similar binding free energies, thus suggesting a potential mechanism of action through the inhibition of ergosterol synthesis. According to our findings, compound 2 appears as a valuable molecular scaffold to pursue the future development of more potent drugs against candidiasis with fewer side effects than polygodial. These outcomes are significant to broaden the alternatives to treat fungal infections with increasing prevalence worldwide using natural compounds as a primary source for active compounds.

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Section: Introductionmentioning

confidence: 99%

Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients

Marin

Bart

Cortez

et al. 2022

IJMS

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Hand Carriage of Yeast in Student of Medicine, Nursing, and Medical Laboratory Science: Impact of Infection Control Measures

Silva,

Silva

et al. 2024

Microorganisms

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We studied yeast hand carriage of 260 healthcare students. We isolated yeasts in 27 students (10.4%), without differences between medicine, nursing, and medical laboratory science programs and gender. A significant lower prevalence of carriage was shown in the clinical cycle (2.7%) compared to the basic cycle (13.5%) (p = 0.022) and the preclinical cycle (13.5%) (p = 0.014). Increased handwashing frequency and the use of alcohol gel and antiseptic soap decreased yeast carriage. Students who applied moisturizing hand cream two or more times a day had a lower frequency of yeast carriage (3.4%) than those who did not use it or used it once a day (16.5%), showing a significant difference (p = 0.016). The most prevalent species was C. parapsilosis sensu stricto (81.5%), followed by Meyerozyma guilliermondii (C. guillermondii) (7.4%), Trichosporon mucoides (7.4%), and R. mucilagenosa (3.7%). One case showed mixed carriage of C. parapsilosis and C. albicans. All strains were sensitive to voriconazole, caspofungin, and anidulafungin. This study shows hand carriage of yeast in health students, mainly by C. parapsilosis, and the frequency of infection control measures and moisturizing hand cream is associated with colonization control.

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Susceptibilidad in vitro a anidulafungina en 100 cepas de especies de Candida aisladas previo a la introducción de esta equinocandina en Chile

Cited by 2 publications

References 14 publications

Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients

Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients

Hand Carriage of Yeast in Student of Medicine, Nursing, and Medical Laboratory Science: Impact of Infection Control Measures

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