Susceptibilidad genética a hantavirus Andes: Asociación entre la expresión clínica de la infección y alelos del sistema HLA en pacientes chilenos

Ferrer, Pablo; G, Marcela Ferrés; M, Paula Godoy; Culza, Analla; C, Claudia Marco; H., Constanza Castillo; C, María Elena Umaña; E, Francisco Rothhammer; R, Elena Llop

doi:10.4067/s0716-10182007000500001

Cited by 13 publications

(2 citation statements)

References 45 publications

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“…In accordance with this supposition, in another study carried out in Slovenia, higher frequencies of the HLA‐B*35 allele were found among HFRS patients infected with Dobrava virus (DOBV) with a fatal outcome [Korva et al, ]. However, a previous study carried out with Chilean individuals infected with ANDV showed that the HLA‐B*35 allele was more frequent among patients with mild disease (without respiratory failure and shock) than those with severe disease, but without statistical significance [Ferrer et al, ]. Furthermore, another study demonstrated that strong HLA‐B*35‐restricted memory T cell responses to ANDV were associated with mild, rather than severe disease, outcome [Manigold et al, ].…”

Section: Discussionmentioning

confidence: 90%

“…Hantavirus cardiopulmonary syndrome is associated with acute thrombocytopenia and changes in vascular permeability that can cause capillary leaking syndrome, leading to inflammatory pulmonary edema, myocarditis, and cardiogenic shock [Saggioro et al, ; Borges and Figueiredo, ]. Several studies have suggested that host genetic polymorphisms may influence the clinical outcome of hantavirus infection, resulting in milder or more severe illness [Mäkelä et al, ; Kilpatrick et al, ; Ferrer et al, ; Wang et al, ; Borges et al, ; Korva et al, ; Laine et al, ]. Furthermore, serological surveys have demonstrated anti‐hantavirus antibodies in individuals without cardiopulmonary illness history [Campos et al, ; Pereira et al, ].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in human leukocyte antigens, human platelet antigens, and cytokine genes in hantavirus cardiopulmonary syndrome patients from Ribeirão Preto, Brazil

Borges

Donadi

Figueiredo

et al. 2013

Journal of Medical Virology

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Hantavirus cardiopulmonary syndrome is a severe human disease associated with hantavirus infection. The clinical course of illness varies greatly among individuals, possibly due to viral and immunological elements and the influence of host genetic factors on clinical outcome. As the magnitude of immune activation has been associated with disease severity, polymorphisms in genes involved in the immune response that may affect the development of this syndrome were investigated. Polymorphisms in the TGF-β, IL-10, IL-6, and IFN-γ genes, human leukocyte antigens (HLA), and human platelet alloantigens (HPA) genes were investigated in 122 patients with Araraquara virus infection from Ribeirão Preto, Brazil. Patients were divided into two groups: hantavirus cardiopulmonary syndrome (HCPS group; n = 26) and hantavirus seropositive only (n = 96). The frequencies of HLA alleles, cytokines and platelet antigen genotypes were evaluated in both groups and compared to a control group. The data demonstrated no significant influence of the HLA alleles, HPA, IL-6, and IL-10 genotypes on susceptibility to hantavirus infection. However, the hantavirus seropositive group presented a significantly higher frequency of a polymorphism associated with a high IFN-γ production than the HCPS group. In addition, a genotype associated with high TGF-β production was found more frequently in individuals infected with hantavirus than in the control group. This phenotype was associated with a less intense thrombocytopenia in the HCPS group and may be protective against the most severe form of hantavirus disease. More studies are required to quantify further the influence of the high TGF-β producer phenotype on the outcome of hantavirus infection.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Polymorphisms in human leukocyte antigens, human platelet antigens, and cytokine genes in hantavirus cardiopulmonary syndrome patients from Ribeirão Preto, Brazil

Borges

Donadi

Figueiredo

et al. 2013

Journal of Medical Virology

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Hantavirus Genetic Diversity

Blasdell

Hentonnen²,

Buchy

2011

New Frontiers of Molecular Epidemiology of Infectious Diseases

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Association of −308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil

et al. 2010

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Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.

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Susceptibilidad genética a hantavirus Andes: Asociación entre la expresión clínica de la infección y alelos del sistema HLA en pacientes chilenos

Cited by 13 publications

References 45 publications

Polymorphisms in human leukocyte antigens, human platelet antigens, and cytokine genes in hantavirus cardiopulmonary syndrome patients from Ribeirão Preto, Brazil

Polymorphisms in human leukocyte antigens, human platelet antigens, and cytokine genes in hantavirus cardiopulmonary syndrome patients from Ribeirão Preto, Brazil

Hantavirus Genetic Diversity

Association of −308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil

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