Survivorship in untreated breast cancer patients

Immobilized Drosophila melanogaster Deoxyribonucleoside Kinase (DmdNK) as a High Performing Biocatalyst for the Synthesis of Purine Arabinonucleotides

“…[3][4][5] Nucleoside analogues are widely used as antiviral and antitumour agents. [6,7] They can be incorporated in the viral or cellular DNA by DNA polymerases after phosphorylation by kinases, or they can inhibit the enzymes involved in the biosynthesis of DNA precursors. [8] Vidarabine (arabinosyladenine, araA), firstly designed as an antineoplastic drug, is now used as a second-line drug for the systemic treatment of Herpex simplex viruses.…”

“…Nucleoside analogues are widely used as antiviral and antitumour agents 6,7. They can be incorporated in the viral or cellular DNA by DNA polymerases after phosphorylation by kinases, or they can inhibit the enzymes involved in the biosynthesis of DNA precursors 8…”

A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow

“…2 For instance, floxuridine (5-fluoro-2′-deoxyuridine) is effective against different types of cancer and it is also an active substance used in the manufacturing of vaccines against SARS-related coronaviruses. 3–5…”

Utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with rapid on-site evaluation (ROSE) for the molecular classification of progressive breast cancer

“…These lymph nodes must be sampled to reach a diagnostic conclusion 1 . In the United States, most patients do not present metastases at the time of diagnosis, but 30% of patients who initially had a limited disease and initiate treatment may have distal metastases in the bones, lung, liver, and lymph nodes 2 .…”

“…There are several techniques available for sampling lymph nodes, such as conventional transbronchial needle aspiration (c-TBNA), computed tomography-guided transthoracic needle aspiration (CT-guided TNAB), ENB (Electromagnetic Navigation Bronchoscopy), transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA), and mediastinoscopy [1][2][3][4][5] . These techniques have certain disadvantages, such as the low possibility of obtaining a sample in lesions smaller than 2 cm with bind puncture, problems with gaining access to central mediastinal locations by a percutaneous approach, the non-availability of techniques like ENB in our environment, the limited access to certain lymph stations by EUS-FNA and mediastinoscopy; in addition, some complications such as pneumothorax, bleeding, air embolization, dysphonia, among others, may occur 5 .…”