Survivorship Analysis in Asymptomatic COVID-19+ Hip Fracture Patients: Is There an Increase in Mortality?

Abstract

Purpose Mortality rates following hip fracture surgery have been well-studied. This study was conducted to examine mortality rates in asymptomatic patients presenting for treatment of acute hip fractures with concurrent positive COVID-19(+) tests compared to those with negative COVID-19(–) tests. Materials and Methods A total of 149 consecutive patients undergoing hip fracture surgery during the COVID-19 pandemic at two academic medical centers were reviewed retrospectively. Patients were divided into two groups for comparative analysis: one group included asymptomatic patients with COVID-19+ tests versus COVID-19– tests. The primary outcome was mortality at 30-days and 90-days. Results COVID-19+ patients had a higher mortality rate than COVID-19– patients at 30-days (26.7% vs 6.0%, P =0.005) and 90-days (41.7% vs 17.2%, P =0.046) and trended towards an increased length of hospital stay (10.1±6.2 vs 6.8±3.8 days, P =0.06). COVID-19+ patients had more pre-existing respiratory disease (46.7% vs 11.2%, P =0.0002). Results of a Cox regression analysis showed an increased risk of mortality at 30-days and 90-days from COVID-19+ status alone without an increased risk of death in patients with pre-existing chronic respiratory disease. Conclusion Factors including time to surgery, age, preexisting comorbidities, and postoperative ambulatory status have been proven to affect mortality and complications in hip fracture patients; however, a positive COVID-19 test result adds another variable to this process. Implementation of protocols that will promote prompt orthogeriatric assessments, expedite patient transfer, limit operating room traffic, and optimize anesthesia time can preserve the standard of care in this unique patient population.

Comparing the 30-Day Mortality for Hip Fractures in Patients with and without COVID-19: An Updated Meta-Analysis

“…Finally, we conducted a meta-analysis and systematic review, including 40 eligible studies with 17,753 patients with hip fractures, among which were 2280 patients with COVID-19 (12.8%) [11,. Except for Vialonga et al (2020), all studies had a research period in 2020 [54]. Hall et al (2022) reported the highest number of COVID-19 infections with 651 [36], followed by Rashid et al (2022) with 517 infections [50].…”