Survivin, sonic hedgehog, krüppel-like factors, and p53 pathway in serous ovarian cancer: an immunohistochemical study

Expression of human dCTP pyrophosphatase 1 (DCTPP1) and its association with cisplatin resistance characteristics in ovarian cancer

“…In tumour cells, chemical agents and the abnormal nucleotide metabolism resulting from rapid proliferation often lead to the generation of a large quantity of intermediates and abnormal nucleotides, triggering the activation of the P53 signalling pathway, thereby inducing cell apoptosis or cell cycle arrest to prevent further proliferation of damaged cells. [30][31][32][33] and the regulatory patterns of DCTPP1 in cisplatin-sensitive and drug-resistant cells exhibit notable distinctions. Moreover, consistent with these findings, clinical specimens exhibiting clinical manifestations of cisplatin resistance displayed higher expression of DCTPP1 compared to specimens demonstrating cisplatin sensitivity.…”

“…Dysregulation of pyrimidine nucleotide metabolism is implicated in cancer progression, making it a relevant area of study in OC. In tumour cells, chemical agents and the abnormal nucleotide metabolism resulting from rapid proliferation often lead to the generation of a large quantity of intermediates and abnormal nucleotides, triggering the activation of the P53 signalling pathway, thereby inducing cell apoptosis or cell cycle arrest to prevent further proliferation of damaged cells 30–33 . Tumours require certain mechanisms to regulate the balance of pyrimidine metabolism in response to the pressure of rapid proliferation and the effects of chemotherapeutic agents 28,29,34 .…”

“…In tumour cells, chemical agents and the abnormal nucleotide metabolism resulting from rapid proliferation often lead to the generation of a large quantity of intermediates and abnormal nucleotides, triggering the activation of the P53 signalling pathway, thereby inducing cell apoptosis or cell cycle arrest to prevent further proliferation of damaged cells. 30 , 31 , 32 , 33 Tumours require certain mechanisms to regulate the balance of pyrimidine metabolism in response to the pressure of rapid proliferation and the effects of chemotherapeutic agents. 28 , 29 , 34 Studies have indicated that DCTPP1 exhibits a strong preference for abnormal dCTP, with the highest activity observed for 5‐iodo‐dCTP, followed by 5‐bromo‐dCTP, unmodified CTP, 5‐methyl‐dCTP and 5‐chloro‐dCTP.…”

Hedgehog pathway and cancer: A new area (Review)

“…For instance, TNF-α induces the expression of activator protein 1 family members and regulates apoptosis through the HH pathway ( 180 , 181 ). Survivin, another inhibitor of apoptosis family, has been revealed to be a transcriptional target of GLI ( 182 ). HH/GLI1 signaling mediates the RNA polymerase III signaling pathway and tRNA synthesis to regulate the cell cycle and death receptor binding ( 183 ).…”