Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis

Duan, Liang; Hu, Xuefei; Jin, Yuxing; Liu, Ruijun; You, Qingjun

doi:10.1186/s12885-016-2304-3

Cited by 21 publications

(21 citation statements)

References 31 publications

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“…Although a meta-analysis performed by Duan et al (27) indicates survivin expression was correlated with tumor stage, but not pathological type and tumor size. They also reported higher survivin expression in patients with NSCLC compared with normal controls.…”

Section: Discussionmentioning

confidence: 95%

Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis

Hassan

Abuhamdah

Abdel-Bary

et al. 2020

Preprint

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Background: Survivin is a common member of the inhibitors of the apoptosis protein (IAP) family and promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein with a potential for tumor suppression or propagation. The aim of this study was to validate the expression levels of survivin and fibulin-3 in benign and malignant respiratory diseases.Methods: This case-control study included 219 patients categorized into 5 groups. Group A included 63 patients with lung cancer, group B included 63 patients with various benign lung diseases, group D included 45 patients with malignant pleural mesothelioma (MPM) and group E included 48 patients with various benign pleural diseases. Group C included 60 healthy individuals (control group). Serum survivin and fibulin-3 levels were measured using ELISA assay kits, while their nuclear expression in the lung and pleura was assessed using western blot analysis. Data entry and data analysis are done using SPSS version 19. The Medcalc Program was used to calculate sensitivity, specificity and positive and negative predictive values with calculation of the AUC (95% CI). Results: The overall results showed significantly higher survivin serum levels with significantly lower fibulin-3 levels among group A when compared with both patients in group B and the controls (p<0.001 for all). There were statistically significant higher serum levels of survivin and fibulin-3 among group D when compared with both patients in group E and the controls (p<0.001 for all). These findings were consistent with nuclear survivin and fibulin-3 expression levels. Fibulin-3 was more valid than survivin in discriminating lung cancer from MPM (p˂0.05). Conclusions: Survivin and fibulin-3 could be helpful diagnostic markers for lung and pleural cancers. Fibulin-3 was more specific in differentiating lung cancer from MPM.Trial registration: ClinicalTrials.gov Identifier: NCT04413292: https://clinicaltrials.gov/ct2/show/NCT04413292, retrospectively registered.

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Section: Discussionmentioning

confidence: 95%

Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis

Hassan

Abuhamdah

Abdel-Bary

et al. 2020

Preprint

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“…A meta-analysis study including 3,206 non-small cells lung cancer (NSCLC) patients and 816 normal controls, BIRC5 was found to be overexpressed in tumor samples and strongly correlated with histological differentiation, tumor-node-metastasis stage and lymph node metastasis, which indicates that BIRC5 may be a tumor progression marker for such cancer type (Duan et al, 2016). Another study indicated that BIRC5 may be involved in chemoresistance of NSCLC cells (Hu et al, 2016).…”

Section: Lung Cancermentioning

confidence: 99%

BIRC5 (baculoviral IAP repeat containing 5)

Branco¹,

Jimenez²,

Machado-Neto³

et al. 2019

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BIRC5, also known as survivin, has been implicated in cell cycle progression and apoptosis avoidance. BIRC5 is highly expressed in embryonic tissues, however very low or absent in adult tissues. BIRC5 overexpression has been frequently associated to cancer development, a poor prognosis and chemoresistance. Besides that, different BIRC5 isoforms has been characterized and related to better or worse chemotherapy responses depending on the isoform and the cancer type. So far, many efforts have been conducted in order to deplete BIRC5 in cancer cells, including gene therapy, pharmacological and nanotechnological approaches. In this review, we will discuss the role of BIRC5 in cancer cell biology and its clinical significance, demonstrating its DNA/RNA and protein aspects, also its relevance for diagnosis and prognosis, and advances as a target for the treatment of different cancer types.

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“…19 The relationship between survivin, which is an anti-apoptotic protein, and a number of cancers were documented. It may show different functions according to the locations.…”

Section: Discussionmentioning

confidence: 99%

Expression of Survivin in Squamous Cell Lung Cancer and Its Correlation with Prognosis

Taşköylü¹,

Dogu²,

Demiray³

et al. 2017

UHOD

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There are outstanding studies on the importance of survivin and inhibition of apoptosis in many cancers, including lung. Evaluation of the relationship between survivin expression in lung cancer and prognosis is the aim of this study. A total of 50 patients with a diagnosis of squamous cell lung carcinoma were included in this study. Survivin levels that were obtained with IHC (immunohistochemical) and RT-PCR (reverse transcription-polymerase chain reaction) methods from the tumor and metastatic lymph node tissues embedded in paraffin blocks were evaluated along with clinical parameters. The median age of the patients was 60 years (range 54-69). All patients were male and all of them were smokers. The mean duration of follow-up and disease-free survival was 42.08±22.46 months and 40.62±22.46 months, respectively. Significant associations were found among survivin levels in metastatic lymph nodes and duration of smoking (IHC and RT-PCR), angiolymphatic invasion (IHC), the number of mitosis (RT-PCR) ( p= 0.05 and p= 0.05, p< 0.001, p= 0.02, respectively). Survivin showed statistically significant associations with angiolymphatic invasion and stage in multivariate analysis (p< 0.001, p= 0.04, respectively). An association was not found between survivin levels in tumor and lymph nodes and survival. Higher survivin levels in lymph nodes detected by IHC was associated with shorter survival but that didn't reach statistical significance (65.22±5.16 vs 42.33±11.97, p= 0.72). Further larger studies done with larger numbers of patients are required in order to evaluate its effects in our society.

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Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis

Cited by 21 publications

References 31 publications

Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis

Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis

BIRC5 (baculoviral IAP repeat containing 5)

Expression of Survivin in Squamous Cell Lung Cancer and Its Correlation with Prognosis

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