Survivin in Synergy With Baf/Swi Complex Binds Bivalent Chromatin Regions and Activates Dna Damage Response in Cd4+ T Cells
Venkataragavan Chandrasekaran,
Karin M.E. Andersson,
Malin Erlandsson
et al.
Abstract:This study explores a regulatory role of oncoprotein survivin on the bivalent regions of chromatin (BvCR) characterized by concomitant deposition of trimethylated lysine of histone H3 at position 4 (H3K4me3) and 27 (H3K27me3). Intersect between BvCR and chromatin sequences bound to survivin demonstrated their co-localization on cis-regulatory elements of genes which execute DNA damage control in primary human CD4+ cells. Survivin anchored BRG1-complex to BvCR to repress DNA damage repair genes in IFNg-stimulat… Show more
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