Survivin Clinical Features in Cervical Cancer

Abstract

Cervical cancer is the primary lethal malignancy for women worldwide, but because it develops over time, it would be one of the most preventable types of cancer. Dysregulation of apoptosis in cells plays a critical role in the malignancy development. Survivin is the smallest inhibitor apoptotic protein (IAP) which has an important part in regulating cell division and inhibitor of apoptosis. This review focused on survivin features in cervical cancer from mechanisms of malignancy relationship to human papillomavirus (HPV) infection through E6 oncogenic protein, role as a biomarker in diagnosis, prognosis, staging and prediction of metastasis, and also as a target for therapy. Regulation of survivin divided into two main groups; cell cycle dependent and cell cycle independent pathway to maintain life and death balance. Survivin expression is upregulated by E6 protein simultaneously repressing p53. Thus cancerous cervical tissue developed. Survivin is also upregulated in hypoxia, a common condition in many tumors and increased angiogenesis. Survivin plays a significant role in chemotherapy and radiation resistance in many cases of cervical cancer. As a target of therapy, survivin has a promising performance, suggested very specific, no issue of resistance and also enhance the effectiveness of chemo and radiation therapy. The goal of treatment is to lower survivin expression through transcription inhibition, immunotherapy based on cytotoxic T lymphocytes (CTL) activity and gene therapy.

Enhance Mitochondrial Damage by Nuclear Export Inhibition to Suppress Tumor Growth and Metastasis with Increased Antitumor Properties of Macrophages

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Parkia speciosa Seeds Ethanol Extract as Co-chemotherapeutic Agent for Doxorubicin Toward Tongue Cancer

“…(18) To achieve optimal induction of apoptosis, specific markers and signaling pathway of the targeted cancer cell should be investigated. (19)(20)(21)(22)(23) Information of targeted cancer genetics and epigenetics will provide a better approach and risk assessment. ( 24) Due to angiogenesis, signaling pathways in angiogenesis as well as endothelial generation were also taken placed.…”

Anti-proliferative and Apoptotic Activities of Kasturi Tobacco (Nicotiana tabacum L.) Leaf Resinoid on Cervical Cancer Cell

“…Dysregulation of apoptosis in cells plays an important role in the development of malignancies. (18) To initiate apoptosis, it is necessary to activate Caspase-3 (19,20), which plays a role in the destruction of many functional and structural proteins in cells (21,22). In this regard, therapeutic targeting of apoptosis is considered as an important strategy for developing anti-tumor agents, because cancer has the ability of cell proliferation and inhibition of apoptosis.…”