Survival With Ecthyma Gangrenosum, a Previously Fatal Complication of Burns

Systemic colistin use in children without cystic fibrosis: a systematic review of the literature

“…This fact raised suspicion regarding the safety profile of systemic colistin treatment, which was illustrated by the gradual withdrawal of parenteral colistin treatment from clinical practice during the late 1970s and early 1980s [76]. The significant number of older studies (21 of 25 included) [44][45][46][47]50,[52][53][54][56][57][58][59][60][61][62][63][64][65][66][67][68] generated from our literature search and also included in this review illustrates the common use of systemic colistin for the treatment of children with Gram-negative infections and also for prophylaxis until the late 1970s. The lack of published experience regarding the systemic use of colistin in the 1980s and early 1990s is the result of the fear of nephrotoxicity that led to the abandonment of colistin after the negative experience provided by the case reports referring to children and included in our study, as well as from studies referring to adult populations [77][78][79].…”

“…Among these, 25 articles (10 case series and 15 case reports) qualified for inclusion in this review . The 10 case series included in the review presented a total of 355 children [49,52,[57][58][59]62,63,65,67,68] and the 15 case reports presented 15 children [44][45][46][47][48]50,51,[53][54][55][56]60,61,64,66]. The detailed process of the selection of eligible trials is depicted graphically in Fig.…”

“…Six deaths were reported; two were attributed to the index infection [54,56], one due to secondary haematogenous infection [66], two due to cardiac arrest [48,53] and the remaining one due to acute renal failure attributed to colistin overdosage [61]. Relevant data were not provided for the remaining 5 of the 15 included children [44][45][46][47]60].…”

“…[44][45][46][47][48]50,51,[53][54][55][56]60,61,64,66].3.2.1. Case series reporting data regarding colistin usage for the treatment of bacterial infections 3.2.1.1.…”

Ecthyma Gangrenosum in a Patient With Toxic Epidermal Necrolysis

“…14 However, an incidence as great as 40% has been reported in some small series. 15 This discrepancy may be attributable to a lack of knowledge about ecthyma gangrenosum and physician failure to correctly diagnose the condition. The original source of bacteremia does not seem to affect an individual's risk of developing ecthyma gangrenosum.…”