Survival trends of metastatic small intestinal neuroendocrine tumor: a population-based analysis of SEER database

Shah, Chintan; Mramba, Lazarus K.; Bishnoi, Rohit; Unnikrishnan, Athira; Duff, Jennifer; Chandana, Sreenivasa R

doi:10.21037/jgo.2019.05.02

Cited by 27 publications

(32 citation statements)

References 27 publications

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“…The proposed nomograms in our study included several independent prognostic factors-age, tumor grade, AJCC stage, surgery and chemotherapy-that were identi ed by applying both forward and backward stepwise selection methods in a Cox regression model. A previous study [13] indicated that age, poor differentiation of the tumor and surgery were signi cantly independent factors for patients with metastatic small intestinal neuroendocrine tumor, which was in line with our results. Chemotherapy is the main treatment method for GI-NECs, and it has also been reported that radiotherapy can play a part in improving survival outcomes for these patients [23].…”

Section: Discussionsupporting

confidence: 93%

Development and Validation of Prognostic Nomogram for Patients With Small Intestinal Neuroendocrine Carcinoma

et al. 2020

Preprint

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Small intestinal neuroendocrine carcinomas (SI NECs) are diagnosed very rarely, and the prognosis is extremely poor due to the metastatic disease of most patients at the time of diagnosis. This study aimed to establish nomogram models for prognostic evaluation of SI NEC in both overall survival (OS) and cancer-specific survival (CSS). Patients diagnosed with SI NEC between 2010 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and further randomly divided into the training and validating cohorts at a ratio of 7:3. Univariate and multivariate cox analysis was conducted to determine significant variables for construction of nomogram. The performance of the nomogram models were then assessed by concordance index (C-index), calibration plot and the area receiver operating characteristic (ROC) curve (AUC). A total of 1110 patients were retrospectively selected from the SEER database. Multivariate models revealed that age, tumor grade, American Joint Committee for Cancer (AJCC) stage, surgery and chemotherapy all showed a significant association with OS and CSS. The discrimination of nomogram for OS prediction was superior to that of the 7th AJCC Tumor-Node-Metastasis (TNM) staging system (C-index = 0.798, 95% CI, 0.762 - 0.833 vs 0.623, 95% CI, 0.580 - 0.666, P < 0.001). Similar results were also observed in CSS nomogram. Well-corresponded calibration plots were noticed using the nomograms. The comparisons of AUC values showed that the established nomograms exhibited better discrimination power than 7th TNM staging system for OS and CSS prediction. In conclusion, we have successfully established novel nomograms for predicting OS and CSS in patients with SI NEC, which can assist clinicians in making predictions about individual patient survival and provide improved treatment strategies.

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Section: Discussionsupporting

confidence: 93%

Development and Validation of Prognostic Nomogram for Patients With Small Intestinal Neuroendocrine Carcinoma

et al. 2020

Preprint

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“…In the cohort 192 patients (48%) were male and 208 patients (52%) were female. Median age was 63 years (IQR [55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71]. A total of 244 patients (61%) were referred within 3 months of diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…52,53 Approximately, nearly half of the patients have metastases at time of diagnosis, predominantly in the liver and during the course of their disease, up to an estimated 90% of the patients will ultimately develop liver metastases (LM) affecting survival. [54][55][56][57] In case of LM, serotonin and other vasoactive mediators can not be (completely) metabolized by the liver, inducing functional symptoms e.g. carcinoid syndrome.…”

Section: Resultsmentioning

confidence: 99%

“…It was first described as a trabecular carcinoma of the skin by Cyril Toker in 1972. 55 The tumour cells showed histopathological similarities with normal Merkel cells, which are neuroendocrine cells of the skin and located in the basal layer of the epidermis. Due to their similarities, this trabecular carcinoma was considered to originate from Merkel cells and were referred to as MCC.…”

Section: -Small Intestine Netsmentioning

confidence: 91%

“…Genomic events and altered expressions describes in selected studiesThe studies presented in this review identified the deregulation of the expression of multiple genes in SI-NETs, which are commonly associated with carcinogenesis in other tumours. In the figure above, only those molecular alterations that have been found in multiple studies are depicted, together with their presumed role as key regulators of different cell functions and their possible effect on tumour progression as defined by the hallmarks of cancer55 …”

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confidence: 99%

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Studying Prognosis and Treatment in Patients with Neuroendocrine Neoplasia

Veenendaal¹,

Michèle²

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Socioeconomic disparities in patients with small bowel neuroendocrine tumors

DiPeri,

Manguso,

Gong

et al. 2023

Journal of Surgical Oncology

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Background and ObjectivesDemographic and socioeconomic disparities affect cancer specific outcomes in numerous malignancies, but the impact of these for patients with small bowel neuroendocrine tumors (SBNETs) is not well understood. The primary objective was to investigate the impact of demographic and socioeconomic factors on overall survival (OS) for patients with SBNETs.MethodsWe performed a retrospective cohort study utilizing the National Cancer Database to assess patients diagnosed with SBNET between 2004 and 2015. Patients were stratified by demographics, socioeconomic factors, insurance status, and place of living.ResultsThe 5‐year OS for the entire cohort was 78.5%. The 5‐year survival was worse in patients with lower income (p < 0.0001), lower education (p < 0.0001), not in proximity to a metro area (p = 0.0004), and treatment at a community cancer center (p < 0.0001). Adjusting for age and sex, factors associated with worse OS were lower income (<$38 000) (hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 1.04−1.28), lower education (>20% no HSD) (HR: 1.14, 95% CI: 1.02−1.26), no insurance (HR: 1.66, 95% CI: 1.33−2.06), and not living in proximity to a metro area (HR: 1.27, 95% CI: 1.10−1.47).ConclusionsPatient demographics and socioeconomic factors play an important role in survival of patients with SBNETs, specifically proximity to a metro area, median income, education level, and type of treatment center. Strategies to improve access to care must be considered in this at‐risk population.

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Survival trends of metastatic small intestinal neuroendocrine tumor: a population-based analysis of SEER database

Cited by 27 publications

References 27 publications

Development and Validation of Prognostic Nomogram for Patients With Small Intestinal Neuroendocrine Carcinoma

Development and Validation of Prognostic Nomogram for Patients With Small Intestinal Neuroendocrine Carcinoma

Studying Prognosis and Treatment in Patients with Neuroendocrine Neoplasia

Socioeconomic disparities in patients with small bowel neuroendocrine tumors

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