Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis

Dong, Xuezhi; Noorbakhsh, Abraham; Hirshman, Brian R.; Zhou, Tianzan; Tang, Jessica; Chang, David C.; Carter, Bob S.; Chen, Clark C.

doi:10.1093/nop/npv016

Cited by 36 publications

(48 citation statements)

References 45 publications

(37 reference statements)

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“…Consequently, they cannot easily be cured by surgical resection alone. Patients with diffusive astrocytomas typically survive for 5 to 8 years and display symptoms related to increased ICP [33,35,36]. We show below that taking v = O(1) and ρ = O(1) corresponds to a diffusive astrocytoma.…”

Section: Diffusive Astrocytoma (Grade Ii)mentioning

confidence: 84%

“…Glioblastomas (GBM) are the most rapidly growing and malignant of astrocytomas [1]. GBM are extremely aggressive, and patients have an average survival period of 12 to 18 months post-diagnosis [35]. We show below that taking v = O(1/ ), so that v =v/ , corresponds to GBM.…”

Section: Glioblastoma Multiforme (Grade Iv)mentioning

confidence: 91%

“…Pilocytic astrocytomas are benign, slow growing tumors of moderate cellularity. Patients with grade I astrocytomas have a good prognosis in general because gross total resection is typically curative [35]. Despite this, these tumors can become very large and remain asymptomatic for prolonged periods of time due to minimal changes in ICP [33,36].…”

Section: Pilocytic Astrocytoma (Grade I)mentioning

confidence: 99%

“…Anaplastic astrocytomas are malignant tumors with a mean survival of three years [35]. They are more aggressive than grade I and II astrocytomas and tend to have tentacle-like projections [36].…”

Section: Anaplastic Astrocytoma (Grade Iii)mentioning

confidence: 99%

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A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

Sorribes¹,

Byrne

Moore³

et al. 2018

Preprint

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Brain tumor growth and tumor-induced edema result in increased intracranial pressure (ICP), which, in turn, is responsible for conditions as benign as headaches and vomiting, or as severe as seizures, neurological damage, or even death. Therefore, it has been hypothesized that tracking ICP dynamics may offer improved prognostic potential in terms of early detection of brain cancer and better delimitation of the tumor boundary. However, translating such theory into clinical practice remains a challenge, in part, due to an incomplete understanding of how ICP correlates with tumor grade. Here, we propose a multiphase mixture model that describes the biomechanical response of healthy brain tissue -in terms of changes in ICP and edema -to a growing tumor. The model captures ICP dynamics within the diseased brain and accounts for the ability/inability of healthy tissue to compensate for this pressure. We propose parameter regimes that distinguish brain tumors by grade thereby providing critical insight into how ICP dynamics vary by severity of disease. In particular, we offer an explanation for clinically observed phenomena such as lack of symptoms in low grade glioma patients versus a rapid onset of symptoms in those with malignant tumors. Our model also takes into account the effects tumor-derived proteases may have on ICP levels and extent of tumor invasion. This work represents an important first step towards understanding the mechanisms that underlie the onset of edema and ICP in cancer-afflicted brains. Continued modeling effort in this direction has the potential to make an impact in the field of brain cancer diagnostics.

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Section: Diffusive Astrocytoma (Grade Ii)mentioning

confidence: 84%

Section: Glioblastoma Multiforme (Grade Iv)mentioning

confidence: 91%

Section: Pilocytic Astrocytoma (Grade I)mentioning

confidence: 99%

Section: Anaplastic Astrocytoma (Grade Iii)mentioning

confidence: 99%

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A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

Sorribes¹,

Byrne

Moore³

et al. 2018

Preprint

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“…Based on methods described in previous studies [19][20][21][22][23][24][25], the time period was divided into approximately equal intervals (1999-2003, 2004-2008, and 2009-2012). To avoid potential biases related to variable length of follow-up (i.e.…”

Section: Time Trend Analysis Of Overall Survivalmentioning

confidence: 99%

Survival trends of oligodendroglial tumor patients and associated clinical practice patterns: a SEER-based analysis

Brandel¹,

Al-Attar²,

Hirshman³

et al. 2017

J Neurooncol

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There is limited information on the management strategies and survival trends for oligodendroglioma patients. Here we used the Surveillance, Epidemiology and End Results (SEER, 1999-2012) database to analyze the historical trends of oligodendroglioma patient survival and correlate these trends to evolving clinical practice of radiation therapy (RT) use and surgical practice of gross total resection (GTR). We identified 2689 World Health Organization (WHO) grade II oligodendroglioma (abbreviated as O2) and 1191 WHO grade III oligodendroglioma (abbreviated as O3). Time-trend analyses were performed for overall survival, radiation treatment (RT) use, and extent of surgical resection (EOR). In multivariable Cox models that accounted for age, race, sex, tumor size, tumor location, EOR, and RT status, the hazard of dying from O3 has significantly decreased over the study period (p < 0.01), while the hazard of dying from O2 has remained largely unchanged. A search of the published literature revealed articles reporting results largely supportive of these observations. The pattern of surgical practice and RT for O3 patients remained unchanged throughout the study period, suggesting that the survival improvement may be related to evolving patterns of medical management. Results from the SEER database indicate significant gains have been made in survival for O3 patients between 1999 and 2012. Such gains were not observed for O2 patients during this study period.

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Diagnostic imaging, treatment and outcome in a 14‐month‐old Dobermann with brainstem gemistocytic astrocytoma

Manzanedo‐Delgado¹,

Mason²,

Pumarola

et al. 2021

Vet Record Case Reports

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A 14-month-old male neutered Dobermann presented for investigations into lingual paresis, dysphagia and proprioceptive ataxia of the pelvic limbs. Magnetic resonance imaging (MRI) revealed a mass lesion in the brainstem. Treatment with glucocorticoids and radiation therapy (RT) achieved a good quality of life for 6 months, after which deterioration occurred. Repeated MRI revealed an expansion of the mass lesion, after which the owners elected for the patient to be euthanised. Postmortem histological examination and immunohistochemistry confirmed the presence of a gemistocytic astrocytoma. This case report describes the first case in the veterinary literature of a young dog with a brainstem gemistocytic astrocytoma treated with RT and glucocorticoids, with remission of clinical signs and excellent quality of life for 6 months after treatment.

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Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis

Cited by 36 publications

References 45 publications

A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

Survival trends of oligodendroglial tumor patients and associated clinical practice patterns: a SEER-based analysis

Diagnostic imaging, treatment and outcome in a 14‐month‐old Dobermann with brainstem gemistocytic astrocytoma

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