Survival Trends in Elderly Patients with Glioblastoma in the United States: a Population-based Study

Shah, Binay Kumar; Bista, Amir; Sharma, Sandhya

doi:10.21873/anticanres.11052

Cited by 28 publications

(37 citation statements)

References 15 publications

(16 reference statements)

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“…Some studies were consistent with the previous findings (Hartmann et al, 2010;Lin & Wagner, 2015;Murthy, Krumholz, & Gross, 2004;Rong et al, 2016). Therefore, age is considered a significant predictor of survival time (Shah, Bista, & Sharma, 2016). This study also demonstrates that elderly individuals are more prone to having GBM than GCG, which explains the rarity of GCG.…”

Section: Discussionsupporting

confidence: 91%

“…Also, one study showed that the prognosis for elderly patients with glioblastoma has improved since the introduction of the Stupp regimen (i.e., radiotherapy plus concomitant and adjuvant temozolomide) in 2005 (Shah et al, 2016). Also, one study showed that the prognosis for elderly patients with glioblastoma has improved since the introduction of the Stupp regimen (i.e., radiotherapy plus concomitant and adjuvant temozolomide) in 2005 (Shah et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The present study stated that the mortality rate is higher among GBM and GCG patients diagnosed before 2010 (p < .001). Also, one study showed that the prognosis for elderly patients with glioblastoma has improved since the introduction of the Stupp regimen (i.e., radiotherapy plus concomitant and adjuvant temozolomide) in 2005 (Shah et al, 2016). This indicates that year of diagnosis has a significant impact on the prognosis of glioblastoma patients.…”

Section: Discussionmentioning

confidence: 99%

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Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Abdulrahman

Bukhari

et al. 2019

Brain and Behavior

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Objectives The current study aims to find the differences between glioblastoma multiforme (GBM) and giant cell glioblastoma (GCG) regarding mortality and prognosis among adults and elderly patients in the U.S. Methods and Materials This study is a historical cohort type of study and is conducted on adults and elderly individuals with GBM or GCG from the years 1985–2014 in the U.S. Data were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database. The study exposure was GBM or GCG and the outcome was mortality. The potential confounders were age, sex, race, ethnicity, year of diagnosis, primary site, brain overlap, and surgery. A chi‐square test was used for categorical data. A univariate analysis was used for variables having a p‐value <.05. Potential confounders were selected and evaluated using multivariate logistic regression models to calculate the odds ratio with stepwise selection. Results The study sample was 25,117. The incidences of GBM and GCG were not similar in relation to age group. Also, Spanish–Hispanic ethnicity was independently protective of GBM and GCG as compared to Non‐Spanish–Hispanic ethnicity patients with GBM have a higher mortality rate than do GCG patients. The mortality rate was higher among patients diagnosed before 2010. Conclusion GCG was not statistically significant in association to reduced mortality. Non‐Spanish–Hispanics with GBM or GCG had a higher mortality rate than did Spanish–Hispanics. Factors such as being female, being age 59–65, and having a year of diagnosis before 2010 were independently associated with increased mortality.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Abdulrahman

Bukhari

et al. 2019

Brain and Behavior

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“…Some studies were consistent with the previous findings [17][18][19][20]. Therefore, age is considered a significant predictor of survival time [21]. This study also demonstrates that elderly individuals are more prone to having GBM than GCG, which explains the rarity of GCG.…”

Section: Discussionsupporting

confidence: 91%

Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014

Abdulrahman¹,

Bukhari²,

Faqihi³

et al. 2019

Preprint

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Brain cancer is the tenth leading cause of death in the U.S. Glioblastoma multiforme (GBM) is the most lethal primary malignant central nervous system tumor in adults. The present study employed samples from 1985-2014 to discover the difference in prognosis among glioblastoma subtypes after the evolution of treatment modalities over the past few years. The current study aims to find the differences between Glioblastoma multiforme (GBM) and giant cell glioblastoma (GCG) in terms of prognosis among adults and elderly patients in the U.S. This study is a historical cohort type of study and is conducted on adults and elderly individuals with GBM or GCG from the years 1985-2014 in the U.S. Data were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database. The study exposure was GBM or GCG and the outcome was mortality. The potential confounders were age, sex, race, ethnicity, year of diagnosis, primary site, and surgery. A chi-square test was used for categorical data. A univariate analysis was used for variables having a p-value < 0.05. Potential confounders were selected and evaluated using multivariate logistic regression models to calculate the odds ratio with stepwise selection. The study sample was 25,117. The incidences of GBM and GCG were not similar in relation to age group. Also, Spanish-Hispanic ethnicity was independently protective of GBM and GCG as compared to Non-Spanish-Hispanic ethnicity patients with GBM have a higher mortality rate than do GCG patients. The mortality rate was higher among patients diagnosed before 2010. In conclusion, GCG was not statistically significant in association to reduced mortality. Non-Spanish-Hispanics with GBM or GCG had a higher mortality rate than did Spanish-Hispanics. Factors such as being female, being age >59, and having a year of diagnosis before 2010 were independently associated with increased mortality.

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“…In a retrospective study from the United States, median survival was 77 months for patients with WHO grade II lesions, 21 months for those with grade III lesions and 15 months for those with grade IV lesions (5). A great amount of research has been carried out on the treatment of higher grade (III or IV) lesions, whereas fewer data are available for patients with low-grade (grade II) gliomas (7)(8)(9)(10)(11). Therefore, the present study focused on low-grade gliomas of the brainstem and aimed to provide additional data for this less common situation.…”

mentioning

confidence: 99%

Rotating Gamma System Irradiation: A Promising Treatment for Low-grade Brainstem Gliomas

Phương

Hưng

Ngoc

et al. 2018

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Brainstem gliomas account for about 20% of primary brain tumors in children and for <2% of gliomas in adult patients (1-3). Gliomas of the brainstem are most commonly located in the pons, but are also found in the mesencephalon, the cerebellar peduncles or the medulla oblongata (4). A tumor located in the brainstem can be associated with severe clinical or even life-threatening symptoms, since this part of the brain regulates motion functions, as well as respiratory and circulatory functions. Such tumors include low-and high-grade lesions. The median survival time for patients with a brainstem glioma is about 10 months in children and 30-40 months in adult patients (5). The prognosis depends on the grade according to the World Health Organization (WHO) (6). In a retrospective study from the United States, median survival was 77 months for patients with WHO grade II lesions, 21 months for those with grade III lesions and 15 months for those with grade IV lesions (5). A great amount of research has been carried out on the treatment of higher grade (III or IV) lesions, whereas fewer data are available for patients with low-grade (grade II) gliomas (7-11). Therefore, the present study focused on low-grade gliomas of the brainstem and aimed to provide additional data for this less common situation.Since complete surgical resection is not safely possible in many of these patients, radiotherapy is the most common treatment. In order to allow for optimal sparing of normal tissues and structures surrounding the tumor, radiotherapy of brainstem gliomas should ideally be performed with highprecision techniques such as intensity-modulated radiotherapy, fractionated stereotactic radiation therapy or stereotactic radiosurgery (SRS). SRS is defined as singlefraction treatment, mostly performed with a linear accelerator or a gamma system. Two gamma systems are used for radiosurgery of cerebral lesions, including those located in the brainstem. The classic Gamma-Knife was already introduced about 50 years ago by Lars Leksell (12). The other system, the rotating gamma system (RGS), was developed in the late 1990s (13). The latter system includes technical features of the classic Gamma-Knife (Cobalt-60 sources) and linear acceleratorbased radiosurgery (a rotating gantry). Although radiosurgery with a gamma system appears to be a reasonable option for 957

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Survival Trends in Elderly Patients with Glioblastoma in the United States: a Population-based Study

Abstract: This study shows that the survival of elderly patients with glioblastoma has improved since the introduction of the Stupp regimen. However, there are significant differences in survival rates among various cohorts.

Cited by 28 publications

References 15 publications

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014

Rotating Gamma System Irradiation: A Promising Treatment for Low-grade Brainstem Gliomas

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Survival Trends in Elderly Patients with Glioblastoma in the United States: a Population-based Study

Abstract: This study shows that the survival of elderly patients with glioblastoma has improved since the introduction of the Stupp regimen. However, there are significant differences in survival rates among various cohorts.

Cited by 28 publications

References 15 publications

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985&ndash;2014

Rotating Gamma System Irradiation: A Promising Treatment for Low-grade Brainstem Gliomas

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Product

Resources

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Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014