Survival time following hospital discharge in dogs with palliatively treated primary brain tumors

Rossmeisl, John H.; Jones, Jeryl C.; Zimmerman, Kurt; Robertson, John L.

doi:10.2460/javma.242.2.193

Cited by 60 publications

(67 citation statements)

References 22 publications

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“…A study investigated the MRI characteristics of histological confirmed meningiomas and concluded that it was not possible to predict the meningioma subtype or grade based on MRI features, emphasizing the need for histopathology for an antemortem diagnostic confirmation (Sturges et al, 2008). Another study evaluated potential prognostic factors associated with ST in brain tumors and found no significant correlation between the edema observed on MRI and ST, (Rossmeisl et al, 2013) which was also observed in the present study. At our institution, radiation therapy is always recommended following surgical resection of intracranial tumors; however, radiotherapy was not available in our country during the study period, and owners elected to not pursue this treatment modality due to the logistic difficulties and the expenses that would be associated with pursuing radiotherapy in a different country.…”

Section: Discussionsupporting

confidence: 51%

Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013)

Suñol¹,

Mascort²,

Font³

et al. 2018

Open Vet J.

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Intracranial neoplasia is frequently encountered in dogs. After a presumptive diagnosis of intracranial neoplasia is established based on history, clinical signs and advanced imaging characteristics, the decision to treat and which treatment to choose must be considered. The objective of this study is to report survival times (ST) for dogs with intracranial meningiomas and gliomas treated with surgical resection alone (SRA), to identify potential prognostic factors affecting survival, and to compare the results with the available literature. Medical records of 29 dogs with histopathologic confirmation of intracranial meningiomas and gliomas treated with SRA were retrospectively reviewed. For each dog, signalment, clinical signs, imaging findings, type of surgery, treatment, histological evaluation, and ST were obtained. Twenty-nine dogs with a histological diagnosis who survived >7 days after surgery were included. There were 15 (52%) meningiomas and 14 (48%) gliomas. All tumors had a rostrotentorial location. At the time of the statistical analysis, only two dogs were alive. Median ST for meningiomas was 422 days (mean, 731 days; range, 10-2735 days). Median ST for gliomas was 66 days (mean, 117 days; range, 10-730 days). KaplanMeier analysis indicated that ST was significantly longer for meningiomas than for gliomas (P<0.05). A negative correlation between the presence of a midline shift and ST (P=0.037) and ventricular compression and ST (P=0.038) was observed for meningiomas. For gliomas, there were no significant associations between ST and any of the variables evaluated. In conclusion, the results of this study suggest that, for dogs that survived >7 days postoperatively, SRA might be an appropriate treatment, particularly for meningiomas, when radiation therapy is not readily available. Also, the presence of midline shift and ventricular compression might be negative prognostic factors for dogs with meningiomas.

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Section: Discussionsupporting

confidence: 51%

Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013)

Suñol¹,

Mascort²,

Font³

et al. 2018

Open Vet J.

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“…There are no meaningful data relating to specific tumor types or grades. Published data suggest that for all masses combined, median survival is between approximately 1 and 10 weeks,139, 140, 141, 142 with supratentorial tumors having a better prognosis (median survival approximately 25 weeks) 143. However, anecdotally many clinicians recognize that survival times for some individual patients, even those with intraaxial tumors, can be considerably longer.…”

Section: Palliative Carementioning

confidence: 99%

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Dickinson

2014

Veterinary Internal Medicne

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Intracranial neoplasia is a common clinical condition in domestic companion animals, particularly in dogs. Application of advances in standard diagnostic and therapeutic modalities together with a broad interest in the development of novel translational therapeutic strategies in dogs has resulted in clinically relevant improvements in outcome for many canine patients. This review highlights the status of current diagnostic and therapeutic approaches to intracranial neoplasia and areas of novel treatment currently in development.

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“…Primary brain tumors, in particular the malignant variants, remain a source of significant morbidity and mortality in small animals and humans. 10,11 Current Therapeutic Options…”

Section: Introductionmentioning

confidence: 99%

“…In one study of dogs with brain tumors definitively diagnosed at necropsy, the reported overall median survival was approximately 2 months after diagnosis via brain imaging. 10 Surgical resection and fractionated radiotherapy are currently the principal methods used to treat canine and feline brain tumors, and these therapies are capable of improving both the quality and quantity of life in small animals. However, both surgery and radiotherapy can be associated with treatment-associated morbidity, and local treatment failures after these therapies remain a common cause of death or euthanasia.…”

Section: Introductionmentioning

confidence: 99%

New Treatment Modalities for Brain Tumors in Dogs and Cats

Rossmeisl

2014

Veterinary Clinics of North America: Small Animal Practice

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Survival time following hospital discharge in dogs with palliatively treated primary brain tumors

Abstract: Dogs with palliatively treated primary brain tumors, particularly those with tumors in the cerebellum, pons, or medulla, had a poor prognosis. However, dogs with supratentorial tumors had survival times > 3 months.

Cited by 60 publications

References 22 publications

Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013)

Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013)

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

New Treatment Modalities for Brain Tumors in Dogs and Cats

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