Survival study and treatment strategy for second primary malignancies in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma

Tsou, Yung An; Hua, Chun Hung; Tseng, Hsien Chang; Lin, Meng‐Hung; Tsai, Ming Hsui

doi:10.1080/00016480600951517

Cited by 41 publications

(42 citation statements)

References 11 publications

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“…There have been several studies that examined the prognoses of patients with SPMs (Rafferty and O'Dwyer 2001;Di Martino et al 2002;Tsou et al 2007;Rennemo et al 2008;Chen et al 2010;Dequanter et al 2011). Those studies reported that the prognoses of patients with synchronous SPMs are significantly lower than those with metachronous SPMs and that SPMs in the esophagus or lung contribute to the poorer outcome than the other types of SPMs.…”

Section: Discussionmentioning

confidence: 99%

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Shiga

Tateda

Katagiri

et al. 2011

Tohoku J. Exp. Med.

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Second primary malignancies (SPMs) are one of the most critical problems in treating head and neck cancer patients. Our hospital had 742 patients with a diagnosis of malignant head and neck tumors during the five-year period from 2002 to 2006. In this study, we analyzed 360 of those patients who were assumed to have risk factors such as alcohol and tobacco use: 106 oral, 120 laryngeal, 50 oropharyngeal and 84 hypopharyngeal cancer patients. Synchronous SPMs are defined as second cancers diagnosed at the same time or within 6 months of the diagnosis of the index head and neck cancers. There were 4 (3.8%) and 11 (10.4%) oral cancer patients, 11 (8.3%) and 8 (5.8%) laryngeal cancer patients, 7 (14.0%) and 4 (8.0%) oropharyngeal cancer patients, and 30 (28.6%) and 7 (8.3%) hypopharyngeal cancer patients with synchronous and metachronous SPMs, respectively. The number of metachronous patients with synchronous SPMs tended to increase during this time period. The frequencies of SPMs in oropharyngeal and hypopharyngeal cancer patients are similar to those in oral and laryngeal cancer patients. Notably, the most frequent SPMs are upper gastrointestinal tract cancers in Japan, compared to lung cancers in Europe. The five-year overall survival rate of patients with synchronous SPMs was significantly poorer than that of patients without any other tumor except for the index cancer, according to the Kaplan-Meier analysis. In conclusion, searching for SPMs in the upper gastrointestinal tract is a critical issue in head and neck cancer patients in Japan.Keywords: diagnosis; head and neck cancer; prognosis; second primary malignancy; synchronous and metachronous Tohoku J. Exp. Med., 2011, 225 (1), 5-12. © 2011 Tohoku University Medical Press Squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide and approximately 600,000 patients develop this type of cancer each year around the world. Despite marked improvements in locoregional control of head and neck squamous cell carcinomas over the past several decades, the overall survival rate of the patients has not changed (Pisani et al. 1999;Parkin et al. 2005). One major reason for the lack of improved overall survival of patients with head and neck cancers is the increased risk of developing a second primary malignancy (SPM). Most SPMs originate independently from the index cancers because these tumors are not clonally related as proven by genetic examination (Califano et al. 1999;Shiga et al. 2003). It is thought that this different clonal origin of SPMs results in treatment difficulties. There are two types of SPMs, metachronous and synchronous, and some patients have both types of SPMs. SPMs are critical problems that must be considered to treat patients with head and neck carcinomas. Such treatment happens to be very difficult in some cases because of the advanced stage of the disease and/or difficulties in the management of treatment strategies and timing especially when they have synchronous SPMs. It is well known that smoking and alcohol use are ...

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Section: Discussionmentioning

confidence: 99%

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Shiga

Tateda

Katagiri

et al. 2011

Tohoku J. Exp. Med.

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“…Further evidence from recent investigations into UAD-SPT confirms that patients afflicted with HNSCC-SPT fare better than those with SPT of other origins (pulmonary or oesophageal) [3][4][5][6]. Most recently we analysed the effects of radiotherapy in larynngeal SCCs.…”

Section: Discussionmentioning

confidence: 98%

“…Studies differ widely (2-30%) in their estimated risk of SPT development in part due to inconsistencies in patient selection or diagnostic criteria as well as generally inadequate follow up ( [3][4][5][6]8,10,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. It is generally accepted that diagnosis of the index tumour in concert with the premise of field cancerisation imparts a subsequent permanent risk of developing SPT [2][3][4][5][6]20,27].…”

Section: Discussionmentioning

confidence: 99%

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Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Farhadieh¹,

Otáhal²,

Taghavi³

et al. 2011

JCST

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Objective: Second primary tumours (SPT) have been implicated in the dismal overall survival (OS) of head and neck Squamous cell carcinomas (HNSCC). The incidence of SPT, the SPT diagnostic time-lag and the impact on OS were assessed.Subjects and methods: 363 consecutive patients treated for primary oral SCCs (1967SCCs ( -2004 were analyzed retrospectively in this study. 95.1% and 90.5% of patients reached a minimum follow-up period of 3 and 5 years respectively.Results: Of 363 patients; 68 (18.7%) were diagnosed with metachronous SPT, 49 (13.5%) developed upper aerodigestive tract (UAD)-SPT, 28 (7.7%) were diagnosed with HNSCC-SPT, and 21 (5.8%) developed lung or esophageal carcinoma. Patients with subsequent HNSCC-SPT had a better median survival during follow-up than those not diagnosed with SPTs (p=0.0018). The rate of mortality in these patients showed a substantial increase compared to patients with no subsequent SPT Diagnosis after 144 months. After 200 months the survival experience was no better than those without SPT. Conclusion:These results suggest a better OS for patients afflicted with HNSCC-SPT. This also reflects that at least some of the noted improved OS of HNSCC-SPT patients is due to temporally cumulated risk associated with developing SPT.

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“…According to Tsou et al, 22 in managing SPT in patients with head and neck SCC, curative rather than palliative treatment is preferred when the index tumors have been diagnosed early, when SPT are metachronous and occurs in the head and neck region and also in cases of patients younger than 70 years. The chosen treatment for our patient was curative ranging from surgical resection with and without RT/chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

Lopes

Aquino

Morais

et al. 2015

The Journal of Contemporary Dental Practice

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Aim: This manuscript aims to describe an unusual case of multiple second primary squamous cell carcinomas (SCCs) in several sites of the oral mucosa in a nonsmoker and nondrinker woman and to discuss the diagnostic criteria, clinicopathological aspects and outcome of second primary tumor (SPT). Background:Patients treated for SCC of the head and neck are at high risk for developing SPT arising from the same dysplastic mucosal field. Currently, there is no reliable method to predict which of the patients will develop SPT. Case description:A 64-year-old nonsmoker and nondrinker woman developed several second primary oral SCCs in 7 years of follow-up, most of them being synchronic, treated by surgery without and with chemotherapy and radiotherapy. Conclusion:Patients treated for SCC require a long-term and careful follow-up as the development of SPT contributes with significantly negative impact on the prognosis.Clinical significance: This report describes the diagnosis and management of a very unusual case of several SPTs affecting different sites of the oral mucosa in the same patient. Moreover, the patient had no apparent risk factors associated

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Survival study and treatment strategy for second primary malignancies in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma

Cited by 41 publications

References 11 publications

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

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