Survival status and predictors of mortality among Breast Cancer patients in Adult Oncology Unit at Black Lion Specialized Hospital, Addis Ababa, Ethiopia, 2018

Abstract

Introduction:Breast cancer is a leading cause of death worldwide, and ranks as the fifth cause of death from all cancers, and the most common cause of cancer death in women in both developing and developed countries. Breast cancer ranks as the first most frequent cancer among women in Ethiopia. In spite of the high incidence and mortality rate, survival status among breast cancer patients was not determined in our country. Hence, this study aimed to assess survival status and predictor of mortality among breast cancer patients in Black Lion Specialized Hospital.Objective: the main aim of the study is to assess the survival status and predictor of mortality among Breast Cancer patients in Black Lion Specialized Hospital Adult Oncology Unit in 2018. Methods: An institution based retrospective longitudinal study was conducted in BLSH AdultOncology Unit. All cases of breast cancer registered from January1 st 2012-December30 th , 2014 in BLSH were followed retrospectively for the six-year survival (until december30 th , 2017).Kaplan-meier survival curve together with log rank test were used to test for the presence of difference in survival among predictor variables. Cox regression were used at 5% level of significance to determine the net effect of each explanatory variable on time to death after diagnosis of breast cancer. Results:In this study incidence of mortality was 9.8 per 100 person years (95% CI: 8.49-11.47).The overall median survival time was 56.5(95% CI (53.46 -60.83)) months. The overall estimated survival rate after diagnosis of breast cancer was nearly 27% (95% CI, 17.09 to 36.67 %) at 72 months of follow up. The overall survival rates at 1, 3, and 5 years were, 97.2%, 80.8%, and 46.2% respectively. Predictors of mortality were clinical stage (III&IV),(AHR =1.86), poorly differentiated histology (AHR: 3.

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“…In Africa, breast cancer causes an estimated 168,690 cases and 74,072 deaths (2). In Ethiopia, breast cancer is the commonest cancer type (3), which accounts for 34% of all female cancer cases, according to the Addis Ababa cancer registry survey (4).…”

Female Breast Cancer Patients, Mastectomy-Related Quality of Life: Experience from Ethiopia

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