The presence of social support and medication adherence have a significant impact on the management of chronic renal disease. Aim:The objective of this study was to assess the correlation between sociodemographic and clinical characteristics, perceived social support, and treatment adherence in hemodialysis patients at a provincial hospital in Biliran during the last quarter of 2022. Methods:The present study employed a quantitative research approach utilizing a descriptive-correlational design. Data collection was conducted through the administration of a three-part survey questionnaire. Results:The study's findings indicate a moderate correlation between the job position's sociodemographic profile and the perceived social support from significant others. Similarly, a moderate correlation was observed between the clinical profile of the kind of vascular utilized and the perceived social support from significant others. Astrong and statistically significant association was seen between marital status and compliance with therapy. There was a lack of statistically significant correlation seen between the perceived level of social support and adherence to medication, attendance at hemodialysis sessions, and adherence to food and fluid restrictions in the context of therapy. In general, the findings indicate a lack of statistically meaningful association between perceived social support and treatment adherence. Conclusion:The perceived social support of a significant other is influenced by both employment level and the type of vascular used. When an individual secures employment and develops an arteriovenous fistula, it leads to a heightened perception of social support from their significant other. Consequently, an adherence improvement strategy was established