Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013

Abstract

Burkitt's Lymphoma (BL) has three peaks of occurrence, in children, adults and elderly, at 10, 40 and 70 years respectively. To the best of our knowledge, no study has been conducted to assess predictors of survival in the three age groups. We hypothesized that survival predictors may differ by age group. We, therefore, sought to determine survival predictors for BL in these three groups: children (<15 years of age), adults (40-70 years of age) and elderly (>70 years of age). Using the Surveillance, Epidemiology, and End Results (SEER) database covering the years 2000-2013, we identified 797 children, 1,994 adults and 757 elderly patients newly diagnosed with BL. We used adjusted Cox proportional hazards regression models to determine prognostic factors for survival for each age group. Five-year relative survival in BL for children, adults and elderly were 90.4, 47.8 and 28.9%, respectively. Having at least Stage II disease and multiple primaries were associated with higher mortality in the elderly group. In adults, multiple primaries, Stage III or IV disease, African American race and bone marrow primary were associated with increased mortality whereas Stage IV disease and multiple primaries were associated with worse outcome in children. These findings demonstrate commonalities and differences in predictors of survival that may have implications for management of BL patients.

Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study

“…From available evidence, older age is associated with higher rate of complications from surgery and toxicity from chemotherapy and radiotherapy [ 24 – 26 ]. In addition, there is preponderance of other factors that could affect the outcome of cancer treatment among the elderly, such as impaired organ function, comorbidity and malnutrition [ 27 – 29 ]. These may have led physicians to use less aggressive or shortened treatment courses in order to minimize harm to the elderly patients [ 30 ].…”

Burkitt Lymphoma in Children: An Unusual Presentation

“…On the other hand, on ultrasound of the abdomen, the finding of suspected repetitive lesions in the liver and renal parenchyma, suggested a rapidly progressing neoplasm. In particular, given the age of the child, we believed the presence of LB to be very likely, which is often already disseminated when it occurs with involvement of the cervical lymph nodes (Toma et al, 2007;Lloyd and McHugh, 2010;Mukhtar et al, 2017). In fact, in LB liver and kidney lesions are usually secondary, occur in 17% and 30% of cases respectively, and on ultrasound they can occur as multiple nodulations or hypoechoic masses, as happened in our case (Derinkuyu et al, 2016;Kalisz et al, 2019;Toma et al, 2007;Biko et al, 2009;Di Serafino et al, 2020).…”

Linfoma de Burkitt nasofaríngeo

“…Sin embargo, los niños en comparación con la población adulta presentan mejores tasas de supervivencia. 13,14…”

“…Asimismo, en cerca de un tercio puede haber manifestaciones oftalmológicas, siendo la proptosis lo más frecuente. [10][11][12][13] Dado lo raro de la presentación, el objetivo de este trabajo es informar de un paciente pediátrico con linfoma de Burkitt a nivel de la nasofaringe.…”