Survival outcomes for second primary head and neck cancer: A matched analysis

Bhattacharyya, Neil; Nayak, Vijay

doi:10.1016/j.otohns.2004.08.011

Cited by 31 publications

(12 citation statements)

References 24 publications

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“…In a study of the survival time of MPMN, Wang et al (2005) compared second primary SCLC to first primary SCLC and found no significant differences in efficacy and median survival time. Bhattacharyya and Nayak (2005) found that second primary cancer survival rates were higher than those of the first primary tumors of head and neck cancer, but the results were not statistically significant. In addition, the survival rate of second primary cancer was associated with lesion sites.…”

Section: Discussionmentioning

confidence: 83%

Clinical retrospective analysis of cases with multiple primary malignant neoplasms

2014

Genet. Mol. Res.

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ABSTRACT. The etiological factors, clinical characteristics, diagnosis, treatment strategies, and prognosis of multiple primary malignant neoplasms (MPMNs) were investigated in order to improve its diagnosis and therapy. Clinical data of 170 patients with MPMN who were admitted to the Oncology Department of the First Affiliated Hospital of Anhui Medical University from January 2004 to April 2010 were collected and analyzed retrospectively. The overall incidence of MPMNs was 2.25%. There were 167 cases with duplex primary cancers, 2 cases with triple primary cancers, 1 case with quadruple primary cancer, 46 synchronous MPMNs (SMPMNs), and 124 metachronous MPMNs (MMPMNs). There were 344 malignant neoplasms in the 170 MPMN patients, of which 161 were in the alimentary system, 48 in the respiratory system, 63 in mammary glands, 30 in the genital system, 7 in the urinary system, 23 in the head and neck, and the other 12 were in the brain, hematological system, and soft tissue. There were 22 cases of bilateral primary breast cancer and 41 cases of digestive MPMN. With a median survival time of 24 months, the 1-, 3-, and 5-year cumulative survival rates in the 170 patients were 68.8, 39.1, and 25.2%, respectively. The most common locations of MPMN were the alimentary system, mammary gland, and respiratory system. MPMN 9272 L.L. Xu and K.S. Gu ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 9271-9284 (2014) usually occurred in distinct organs of identical systems, conjugate organs, or identical organs. The survival rate of SMPMN was similar to that of MMPMN. There were differences in principles of treatment and diagnosis between MPMN and metastasis or recurrent cancers.

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Section: Discussionmentioning

confidence: 83%

Clinical retrospective analysis of cases with multiple primary malignant neoplasms

2014

Genet. Mol. Res.

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“…Hypopharyngeal cancer patients appeared to be at highest excess risk of solid tumor SPM development [17]. Depending on head and neck subsite, estimated five-year survival rates for HNSCC patients with a SPM ranged from 0–67%, compared to 36–46% for those without a SPM [18–22]. The difference became more drastic at 10 years, when patients diagnosed with a SPM had a 19–22% survival rate, compared to 55% for those without a SPM.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database

Birkeland

Rosko

Chinn

et al. 2016

ORL

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Background/Aims: Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC. Methods: This is a population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Prevalence and location of SPMs, and survival data were analyzed. Results: There were 58,363 HNSCC patients, and the prevalence of HNSCC and non-HNSCC SPMs was 3.0% (1,746) and 8.8% (5,109), respectively. Overall survival (OS) was higher in patients with HNSCC SPMs compared to non-HNSCC SPMs (p < 0.001), with no difference in disease-specific survival. Patients with SPMs in the lung and esophagus had a worse OS (p < 0.001), and patients with SPMs in the prostate and breast had a better OS (p < 0.001). Conclusion: In HNSCC patients who develop SPMs, nearly 75% are non-HNSCC SPMs. Patients with non-HNSCC SPMs have a lower OS. Future clinical practice guidelines should take the risks and locations of SPM development into consideration for screening.

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“…2,3 The prognosis for patients who develop SPM is less favorable than the prognosis for patients with index SCCHN alone. 6,8,9 …”

Section: Introductionmentioning

confidence: 99%

Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers

Gan

Dahlstrom

Peck

et al. 2013

Cancer

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Background A recent review of the SEER registry suggested that patients with index squamous cell carcinoma (SCC) of the oropharynx (SCCOP) are less likely to develop second primary malignancies (SPM) than patients with index SCC of non-oropharyngeal sites (oral cavity, larynx, hypopharynx). The purpose of this study was to determine the impact of index primary tumor site on SPM risk and explore factors potentially affecting this risk within a large prospectively accrued cohort of patients with index SCC of the head and neck (SCCHN). Methods A cohort of 2230 patients with incident SCCHN was reviewed for development of SPM. Kaplan-Meier analysis, log-rank testing, and Cox proportional hazards models were used to detect the impact of various factors, including index tumor site, on SPM risk. Results The SPM rate was lower for patients with index SCCOP than for patients with index non-oropharyngeal cancer (P<.001). Among SCCOP patients, former-smokers had a 50% greater risk of SPM and current-smokers had a 100% greater risk of SPM than never-smokers (Ptrend=.008). Among SCCOP patients, those with classic SCCHN phenotype had SPM risk similar to that of patients with index non-oropharyngeal cancers; those with typical HPV phenotype had very low SPM risk. SPM most commonly occurred at non-tobacco-related sites in patients with index SCCOP and at tobacco-related sites in patients with index non-oropharyngeal cancers. Conclusion In patients with SCCHN, index cancer site and smoking status affect the risk and distribution of SPM.

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Survival outcomes for second primary head and neck cancer: A matched analysis

Abstract: B-3.

Cited by 31 publications

References 24 publications

Clinical retrospective analysis of cases with multiple primary malignant neoplasms

Clinical retrospective analysis of cases with multiple primary malignant neoplasms

Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database

Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers

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