Survival outcomes for postoperative chemoradiation in intermediate‐risk oral tongue cancers

Spiotto, Michael T.; Jefferson, Gina D.; Wenig, Barry L.; Markiewicz, Mph Michael R.; Weichselbaum, Ralph R.; Koshy, Matthew

doi:10.1002/hed.24932

Cited by 11 publications

(16 citation statements)

References 18 publications

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“…Our 3-year overall survival figure seems similar to other publications like the respectable paper of Spiotto et al (23) who studied 2803 cases. Their 3-year overall survival was from 67%-73%.…”

Section: Discussionsupporting

confidence: 91%

Squamous Cell Carcinoma of the Oral Tongue: A Single Institution Retrospective Cohort Study from Mansoura University Hospital

Hamdy

Halim

2019

Indonesian Journal of Cancer

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Background: Egyptian hospital–based statistics showed that head & neck carcinomas represent 18% of all cancers and mostly diagnosed at advanced stages. Our Clinical Oncology & Nuclear Medicine Department of Mansoura Faculty of Medicine serves a large rural area of the Delta region of Egypt. There is no previous study in our institution that focused on oral tongue carcinoma alone. This study aims in establishing the demographics, treatment outcome and prognostic factors of oral tongue squamous cell carcinoma (SCC).Methods: We retrospectively reviewed data of 50 cases with oral tongue SCC treated in our department from January 2014 to December 2016 to evaluate the demography, pathological characteristics, and therapeutic modalities. We estimated the survival rates during the entire follow-up period by the Kaplan–Meier method. The univariate and multivariate Cox proportional hazards analysis were performed for prognostic factors determination.Results: The median follow-up was 30 months (range: 4-45 months). The 3-year overall survival (OS) and disease-free survival (DFS) rates were 68% and 60% respectively. By univariate analysis, both advanced stages (III, IVA) and depth of invasion >0.5 cm were statistically significant as prognostic factors for 3-year DFS and OS rates. DFS rates were 34% vs. 98% for stage III and IVA vs. stage I and II respectively (p = 0.001); 52% vs. 78% for >0.5 cm vs. ≤0.5 cm depth of invasion (p = 0.003). OS rates were 36% vs. 99% for stage III and IVA vs. stage I and II respectively (p = 0.002); 52% vs. 80% for >0.5 cm vs. ≤0.5 cm depth of invasion (p = 0.001). Multivariate analysis of prognostic factors affecting 3-year DFS and OS rates confirmed the statistical significance of the same 2 factors.Conclusions: The majority of our patients were males below 60 years. Tumors were mainly found at stage III and were moderately differentiated. Vascular invasion and lymphatic permeation were uncommon. Staging and tumor invasion depth significantly affected the outcome. The 3-year OS and DFS were 68% and 60% respectively.

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Section: Discussionsupporting

confidence: 91%

Squamous Cell Carcinoma of the Oral Tongue: A Single Institution Retrospective Cohort Study from Mansoura University Hospital

Hamdy

Halim

2019

Indonesian Journal of Cancer

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“…We observed poorer disease‐free survival in the NM ECS‐free subpopulation of IR‐HNC, which seems to emphasize the unsatisfactory results of PORT alone. This finding is in line with previous studies which have supported the use of postoperative chemoradiotherapy.…”

Section: Discussionsupporting

confidence: 93%

“…Employing the National Cancer Database of 1136 patients, Spiotto et al assessed which oral tongue cancers with IR pathological features derived an advantage from adjuvant chemoradiotherapy. The investigators observed that the prognosis was improved in people with pT3‐T4 and 2 or more positive nodes.…”

Section: Discussionmentioning

confidence: 99%

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Postoperative radiotherapy of intermediate‐risk head and neck cancer in 134 patients: Does subset matter?

Ampil

Caldito

Nathan

et al. 2018

Clinical Otolaryngology

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“…Selection of CRT appears to likely have been driven strongly by higher N stage classification, in accordance with prior research. 5,9 In fact, in another recent study, N2 classification was found to more strongly correlate with aCRT use than either ECE or positive margins, for which this treatment modality is considered the standard of care. 6 Younger age also strongly predicted prescription of aCRT.…”

Section: Discussionmentioning

confidence: 99%

Patterns of care and survival impact of adjuvant chemoradiotherapy for oropharyngeal cancer with intermediate‐risk features

et al. 2019

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Background Survival outcomes for adjuvant chemoradiotherapy (aCRT) and adjuvant radiotherapy (aRT) were compared in patients with oropharyngeal squamous cell carcinoma (OPSCC) with intermediate‐risk features. Methods We identified 2164 patients with OPSCC in the National Cancer Database without positive margins or extracapsular extension and with at least one intermediate‐risk feature: pT3‐T4 disease, ≥two positive lymph nodes, level IV/V nodal disease, and/or lymphovascular invasion. We assessed predictors of aCRT use and covariables impacting overall survival. Results aCRT was commonly used for both human papillomavirus (HPV)‐positive (62.0%) and HPV‐negative (64.3%) patients with OPSCC. Higher N stage, level IV/V neck disease, and younger age strongly predicted aCRT utilization. There was no significant survival benefit associated with aCRT vs aRT in HPV‐positive (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.62‐1.38; P = .71) or HPV‐negative (HR, 0.75; 95% CI, 0.51‐1.10; P = .15) disease. Conclusions Despite high rates of utilization, aCRT is not associated with better survival vs aRT for OPSCC with intermediate‐risk features, including HPV‐negative tumors.

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Survival outcomes for postoperative chemoradiation in intermediate‐risk oral tongue cancers

Abstract: Undergoing S+CRT was associated with improved survival for patients with tongue cancers with ≥2 MLNs and/or pT3-pT4 suggesting that specific intermediate-risk pathological features benefit from treatment intensification.

Cited by 11 publications

References 18 publications

Squamous Cell Carcinoma of the Oral Tongue: A Single Institution Retrospective Cohort Study from Mansoura University Hospital

Squamous Cell Carcinoma of the Oral Tongue: A Single Institution Retrospective Cohort Study from Mansoura University Hospital

Postoperative radiotherapy of intermediate‐risk head and neck cancer in 134 patients: Does subset matter?

Patterns of care and survival impact of adjuvant chemoradiotherapy for oropharyngeal cancer with intermediate‐risk features

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