Survival of Young Patients after Gastrectomy for Gastric Cancer

Abstract

It has been suggested that gastric cancer has a worse prognosis in young patients, but the data are controversial. The aim of this study was to compare the 5-year survivals after gastrectomy for gastric cancer in two groups of patients (those < or = 45 years of age and those (> 45 years) and to determine some of the prognostic factors. The 5-year survival was significantly better for patients < or = 45 years of age. Survival was also better for young patients with a curative resection and also for those with lymph node metastases. However, survival was not significantly different for the two groups when the resection was not curative and when the lymph nodes were not involved. Survival was no different for the two groups when compared at each stage, although a multivariate analysis showed that age > 45 years, moderate or poor degree of differentiation of the tumor, advanced tumors, the presence of lymph node involvement, and a noncurative resection were independent negative prognostic factors. Long-term survival after gastrectomy for gastric cancer depends on the stage of the disease; the age of the patient is not a decisive factor.

Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years

“…Clinicopathological features in the 31 patients younger than 40 years with gastric cancer were characterized by the predominance of female patients with poorly differentiated adenocarcinoma, located in the middle part of the stomach, many of whom had undergone total gastrectomy with D2 or D3 lymph node dissection. The predominance of female patients with poorly differentiated adenocarcinoma that we observed was in accordance with other reports [29,30].…”

Clinicopathological features of gastric cancer in young patients

“…One factor that has been cited as an indicator of poor prognosis of gastric cancer is early onset, i.e., that occurring in patients who are comparatively young [1][2][3][4]. Gastric cancer usually occurs in individuals aged 50-70 years [2,5,6] and is rare in the young [7][8][9]. Factors that contribute to the poor prognosis of gastric cancer in the young include delayed detection, resulting in an advanced stage at presentation, diffuse infiltration of the tumor and a poorly differentiated histology [1,4,10].…”

Disección sub-mucosa endoscópica en cáncer gástrico incipiente

“…Si bien la mortalidad por esta enfermedad ha experimentado un descenso progresivo desde la década de 1970, continúa siendo un importante problema de salud pública, con una mortalidad aproximada de 20 por 100.000 habitantes y una estimación de 3.000 muertes anuales 2 . La sobrevida por cáncer gástrico se encuentra en directa relación con la etapa de la enfermedad, los pacientes en etapa I tienen una sobrevida a 5 años cercana al 90%, dependiendo del grado de invasión de la pared gástrica y de la presencia o ausencia de metástasis linfáticas, mientras que aquellos pacientes en etapa IV tienen una sobrevida a 5 años cercana al 10% dependiendo de las distintas series analizadas 3,4 . Lamentablemente, cerca de un 40% de los pacientes se presenta con enfermedad diseminada al momento del diagnóstico 5 .…”