Survival of Texas infants born with trisomies 21, 18, and 13

Abstract

Trisomies 21, 18, and 13 are the three most common trisomies among infants who survive to 20 weeks gestation or more. Overall information about birth prevalence, natural history, and mortality for all three trisomies is well defined, but information about ethnic-specific rates is limited. Only a few studies have examined mortality rates of trisomies 18 and 13 because so few cases are liveborn and most have very short life spans. This study assessed ethnic-specific population-based survival probabilities among infants for each trisomy. All cases of trisomies 21, 18, and 13 born in Texas between 1999 and 2003 were obtained from the Texas Birth Defects Registry and included 2,260 cases of trisomy 21, 398 cases of trisomy 18, and 213 cases of trisomy 13. Date and cause of death were obtained from the Texas vital statistics records and the National Death Index. Overall, birth prevalence rates (per 10,000 adjusted live births) for the three trisomies were 11.74 (95% CI: 11.25-12.25), 1.34 (95% CI: 1.18-1.52), 0.92 (95% CI: 0.79-1.07), respectively, and are consistent with previously reported rates. There were no differences in survival rates by ethnicity and the median survival for each trisomy was consistent with previous reports. The results of this study provide comprehensive population-based information for survival of infants with trisomies 21, 18, and 13.

Trends in Survival Among Children With Down Syndrome in 10 Regions of the United States

“…Two previous reports in the United States were inconsistent with regard to racial and ethnic disparities in survival 9,15 ; however, the discrepancy is likely the result of 2 study attributes. First, each used non overlapping time periods of observation, so that the later study (Vendola et al) might reflect the narrowing survival gap as evidenced by the decreasing trend in disparities seen in this study.…”

“…Previous survival estimates in the United States have been limited to individual surveillance programs. 9,15,16 Data for most of those studies were subsumed by this study to produce the most nationally representative survival estimates available to date that can serve as a benchmark as well as a comparison point for reports from other countries.…”

“…Previous survival estimates in the United States have been limited to individual surveillance programs. 9,15,16 Data for most of those studies were subsumed by this study to produce the Linkage of surveillance data with the National Death Index ensured the most accurate determination of the vital status of children even if they died out of state and adds significantly to the credibility of the findings 17 ; however, the assumption that a child was alive if there was no record of death found from the three data sources could be a potential limitation of the study. Additionally, no information on surgeries, clinical management, or barriers to health care as potential contributors to the long-term survival of children with DS was examined.…”

Intrauterine death in singleton pregnancies with trisomy 21, 18, 13 and monosomy X

“…1, 3 Trisomies 21 (T21), 18 and 13 (T13/18) and x-chromosome monosomy (45X) are the most frequent aneuploidies in newborns. [4][5][6] Nowadays, tracking programs and prenatal diagnosis of such abnormalities are quite widespread. 1 Conventional prenatal screening is conducted based on parameters such as maternal age (MA), and the study of ultrasound and biochemical markers.…”

Caring for an infant with trisomy 18: A case study and guidelines

“…Reported prevalence rates for infants with full trisomy 18 (Edwards syndrome or trisomy 18, presence of an extra 18th chromosome in every cell) are approximately one in 4000-8500 live births [1][2][3][4][5] . Much of the literature describes the prognosis for infants with trisomy 18 as bleak with multiple medical complications and high mortality rates [2,6] .…”