Survival of Reflex Contraction and Inhibition During Cord Asphyxiation

Harreveld, A. Van

doi:10.1152/ajplegacy.1944.141.1.97

Cited by 15 publications

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“…A priori however, it is just as logical to suppose that early in' development viability depends on cells whose anaerobic capabilities are great, while later it comes to depend on the functioning of some more recently differentiated cells whose anaerobic capabilities are very much less. Supporting this latter conclusion are the facts (1) that the lethal effects of asphyxia are almost certainly exerted within the nervous system (Kabat and Schadewald, 1941; and Weinberger, Gibbon and Gibbon, 1940); (2) that the cells of the nervous system differ in their resistance to asphyxia (Kabat and Schadewald, 1941;Weinberger, Gibbon and Gibbon, 1940;van Harreveld, 1944); and (3) that in the mammal, at least, differentiation in the nervous system is taking place during those post partum stages in which the ability to survive asphyxia shows marked changes (Himwich and Fazekas, 1941). SUMMARY AND CONCLUSIONS 1.…”

Section: Discussionmentioning

confidence: 99%

Developmental Changes in the Viability of Squid Embryos After Subjection to Cyanide

Marvel¹,

Fisher²

1948

The Biological Bulletin

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Section: Discussionmentioning

confidence: 99%

Developmental Changes in the Viability of Squid Embryos After Subjection to Cyanide

Marvel¹,

Fisher²

1948

The Biological Bulletin

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Spinal Cord Compression Studies

TARLOV

1954

AMA Arch NeurPsych

316

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IT IS CLINICALLY important to determine how long the spinal cord may be compressed without precluding functional recovery, because it would lead to more rational and standardized treatment. One would expect the time to be short because of the vulnerability of nerve tissue to mechanical distortion and anoxia. Allen* attempted to answer this question by producing contusion of the spinal cord of dogs. His technique was to drop known weights from known heights on the spinal cord. The degree of the impact was measured in gram-centimeters. Allen believed that the edema following the impact reached its maximum about four hours after the injury. He concluded that if the spinal cord compression caused by the edema could be prevented, the spinal cord might recover some function. Accordingly, he advised midline posterior incision of the spinal cord through the contused segment to drain and release the intramedullary pressure. He made such incisions in dogs two hours after injury by a force known to produce complete paralysis. He reported that he could thus avert the disintegration of cord tissue that invariably occurred in the control dogs in which the spinal cord was not incised.A valid objection to Allen's interpretation of these changes is well expressed by Thompson 12 :There is no doubt that the substance of the cord is clearer and better preserved in the incised than in the nonincised specimen but there is such a decrease in transverse area of the cord that we can't help feeling that the diffluent tissue which escaped from the incision carried with it a considerable amount of nervous tissue which had not been seriously injured and which might have been expected reasonably to have recovered if it had not been disturbed. While it lies in the substance of the cord it acts as support to the uninjured tissue surrounding it. Evacuation removes this support and the walls of the cavity cave in like the sides of a sand pit or the banks of a river when the waters recede. On these grounds we believe that the evacuation is not without its drawbacks and its dangers.Allen's experiments have fallen short, therefore, of solving our problem.

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Über die Sauerstoffversorgung des Gehirns und den Mechanismus von Mangelwirkungen

Opitz-Kiel¹,

Schneider-Köln²

1950

Ergebnisse Der Physiologie Biologischen Chemie Und Experimentellen Pharmakologie

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Survival of Reflex Contraction and Inhibition During Cord Asphyxiation

Cited by 15 publications

References 0 publications

Developmental Changes in the Viability of Squid Embryos After Subjection to Cyanide

Developmental Changes in the Viability of Squid Embryos After Subjection to Cyanide

Spinal Cord Compression Studies

Über die Sauerstoffversorgung des Gehirns und den Mechanismus von Mangelwirkungen

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