Survival of Patients With Sickle Cell Anemia Living at High Altitude

Addae, S; Adzaku, Festus; Mohammed, S; Annobil, Samuel H.

doi:10.1097/00007611-199004000-00033

Cited by 6 publications

(4 citation statements)

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“…Splenic infarct incidence directly correlates with the amount of HbS, especially in patients with an HbS higher than 40% [13]. As an interesting fact, people with SCT who were born in and live in high altitude cities do not present splenic infarcts likely due to an adaptation to low oxygen conditions since childhood [14].…”

Section: Discussionmentioning

confidence: 96%

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

González

Shapiro

Tafur

et al. 2020

Cureus

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The sickle cell trait is considered a benign entity that generally does not show clinical manifestations. However, some complications have been described under certain conditions, such as a decrease in oxygen level, dehydration, and strenuous physical efforts. Among them, splenic infarct is a rare complication that presents as left upper abdominal pain in a situation of stress such as high altitude exposure. We present two cases of splenic infarcts in patients with undiagnosed sickle cell trait who showed to our institution with severe abdominal pain after coming from high altitude cities.

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Section: Discussionmentioning

confidence: 96%

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

González

Shapiro

Tafur

et al. 2020

Cureus

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“…23 Although similar cases have been reported in the past, this case aids in raising awareness of splenic syndrome among healthcare providers at moderate to high altitude and could improve recognition of this condition in the future. [18][19][20] Early recognition and immediate descent are crucial to avoid life-threatening complications. In this case, the patient was managed at a nonmilitary medical center, the diagnosis was delayed, and he was allowed to re-ascend.…”

Section: Discussionmentioning

confidence: 99%

“…17 Addae et al demonstrated that SCT leading to splenic infarction is seen more commonly in lowlanders who ascend to high altitude compared with native highlanders. 20,21 Goodman et al retrospectively studied the features of 25 cases of splenic infarcts with SCT in Colorado. Interestingly, all were men and symptomatic in the first 24 h on ascent to altitude higher than 2300 m (7500 ft).…”

Section: Discussionmentioning

confidence: 99%

A Case of Autosplenectomy in Sickle Cell Trait Following an Exposure to High Altitude

Yanamandra

Das

Malhotra

et al. 2018

Wilderness & Environmental Medicine

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A 24-year-old man presented with acute abdominal pain upon ascent to moderate altitude (3500 m). An immediate evaluation revealed a splenic infarct, and he was evacuated to sea level. Upon recovery, he was sent back to 3500 m without detailed etiological evaluation, whereupon he experienced recurrent episodes of left-side subcostal pain. Imaging suggested autosplenectomy, and workup revealed a negative thrombophilia profile but was positive for sickle cell trait (SCT). Individuals with SCT can be asymptomatic until exposure to severe hypoxia, upon which they can manifest clinically as sickle cell syndrome. We discuss the rare presentation of autosplenectomy in a patient with previously undiagnosed SCT on exposure to high altitude.

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“…Only 47 patients had been reported till 2005, of which one was Indian. It is mostly limited to visitors and is uncommon in native sicklers [7,8].…”

Section: Discussionmentioning

confidence: 99%

Splenic Syndrome due to Sickle Cell Trait amongst Indian Soldiers Serving in Kashmir

Arora

Bhatia

Khanna

et al. 2008

Medical Journal Armed Forces India

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Background: Heterozygous transmission of gene for Haemoglobin S leads to sickle cell trait. Mostly the trait remains silent with no additional morbidity or mortality. When these persons migrate to higher altitudes, in times of high oxygen demand, some of them develop splenic infarction. This is a rare phenomenon and only 47 such cases had been reported till 2005. Methods: This study was conducted at an Indian military hospital serving the troops deployed in Kashmir valley at altitudes ranging from 5500 ft to 13000 ft. When two consecutive splenectomies for splenic abscesses, turned out to be sickling induced infarction histopathologically, we reviewed splenectomy specimens received in last six years for evidence of sickling. Result: Out of 33 splenectomies performed during the period of study, 22 were due to trauma (gun shot injury 11; splinter injury one and blunt injury 10). Of the rest eleven, who presented without any history of trauma, seven had evidence of vascular occlusion with aggregates of sickled red blood cells. In none, Gram stain or Periodic Acid Schiff stain revealed any bacterial or fungal colonies. One patient of splenic syndrome was found to have unrecognised sickle cell trait and he was managed conservatively. Conclusion : Sickle cell trait should be excluded before considering splenectomy in ethnically vulnerable patients presenting with splenic syndrome. An uncomplicated splenic infarction can be managed conservatively. MJAFI 2008; 64 : 123-126

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Survival of Patients With Sickle Cell Anemia Living at High Altitude

Cited by 6 publications

References 0 publications

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

A Case of Autosplenectomy in Sickle Cell Trait Following an Exposure to High Altitude

Splenic Syndrome due to Sickle Cell Trait amongst Indian Soldiers Serving in Kashmir

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