Survival of Patients with First and Metachronous Second Primary Breast Cancer or Lung Cancer Malignancy: Comparisons Using the SEER Database

Zhong, Miaochun; He, Xianghong; Lei, Kefeng

doi:10.1007/s12325-020-01322-0

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…[14][15][16][17][18] For example, as in Case 3 in our series, an association between breast cancer and lung cancer has been previously reported. [19][20][21] Similarly, an association between breast and colorectal cancer has also been previously reported, 22 as in Case 1 in this case series. Nevertheless, most studies have reported the incidence of metachronous second primary malignancies after breast cancer, 14,[16][17][18][19] and only a few studies have investigated the rate of synchronous tumors.…”

Section: Discussionsupporting

confidence: 82%

“…[19][20][21] Similarly, an association between breast and colorectal cancer has also been previously reported, 22 as in Case 1 in this case series. Nevertheless, most studies have reported the incidence of metachronous second primary malignancies after breast cancer, 14,[16][17][18][19] and only a few studies have investigated the rate of synchronous tumors. Metachronous and synchronous malignancies, that might necessitate a change in the treatment plan, may be detected by PET-CT.…”

Section: Discussionsupporting

confidence: 82%

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Synchronous Malignancies Identified by PET-CT Scan in Breast Cancer Patients

Paran

Shulman

Kessel

et al. 2022

Rambam Maimonides Med J

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Breast cancer is a common malignancy and a common cause of cancer-related mortality in women. Pre-treatment workup of breast cancer does not routinely include positron emission tomography scans. We aimed to review cases of women with breast cancer and a synchronous second primary malignancy. We present three cases of women with non-metastatic cancer in whom a synchronous second primary malignancy was found. Synchronous, second primary malignancies which were identified included rectal cancer, gastrointestinal stromal tumor, and non-small cell lung cancer. All second primary malignancies were identified by a PET-CT scan. In conclusion, PET-CT may be used for detection of secondary primary malignancies in select breast cancer patients.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

Synchronous Malignancies Identified by PET-CT Scan in Breast Cancer Patients

Paran

Shulman

Kessel

et al. 2022

Rambam Maimonides Med J

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“…These results showed that the risk of lung cancer in the chemotherapy group was much lower than that in the nonchemotherapy group (RR=0.63, 95% CI: 0.60–0.67). 34 Additionally, in the study by Li et al, approximately half of patients received chemotherapy (120,333/250,764), and the risk of lung cancer in the chemotherapy group was significantly lower than that in the nonchemotherapy group (RR=0.895, 95% CI: 0.818–0.979, P=0.015), 35 which was consistent with the findings reported by previous studies. 7 We considered that this phenomenon might be related to the therapeutic effects of some chemotherapeutic agents for breast cancer, such as docetaxel, paclitaxel and gemcitabine, on lung cancer.…”

Section: Factors Influencing the Risk Of Subsequent Lung Cancer In Breast Cancer Patientssupporting

confidence: 84%

Primary Lung Cancer After Treatment for Breast Cancer

Qian¹,

Wang²,

Che³

2021

IJWH

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Breast cancer is the most common malignancy in women and the second most common cause of cancer-related death. Due to advances in the diagnosis and treatment technologies for breast cancer, patients with breast cancer are living longer than before, resulting in an increased risk of developing subsequent malignancies, among which lung cancer is the most common. This review presents the current evidence about the risk, influencing factors and prognostic factors of developing primary lung cancer after treatment for breast cancer. The aim is to help clinicians improve their understanding, diagnosis and treatment of lung cancer after breast cancer.

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“…Some studies have shown metachronous and synchronous cancer survivorship depends on both the anatomical site of the cancers as well as the temporal relation (e.g., index lung cancer and subsequent breast cancer patients have increased survival than index breast and subsequent lung cancer) ( 9 ). Our study found similar anatomical and temporal relationships to survival.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Survival of Multiple Primary Cancers in US Women With a Gynecologic Cancer

et al. 2022

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ObjectivesTo evaluate risk of a second cancer and associated survival times in United States women with diagnosis of cancer.MethodsThe Surveillance Epidemiology and End Results (SEER) database was queried for 2 cohorts of women aged 18 - 89 with either an index gynecologic or non-gynecologic cancer diagnosed between 1992 – 2017. Index cases were followed to determine if a second primary cancer was subsequently diagnosed; defined according to SEER multiple primary and histology coding rules. Standard Incident Ratios (SIR) and latency intervals between index diagnosis and second primary diagnosis were evaluated. Among those who developed a second primary cancer, median survival times from diagnosis of second primary cancer were also calculated.ResultsBetween 1992 – 2017, 227,313 US women were diagnosed with an index gynecological cancer and 1,483,016 were diagnosed with an index non-gynecologic cancer. Among patients with index gynecologic cancer, 7.78% developed a non-gynecologic subsequent primary cancer. The risk of developing any non-gynecologic cancer following an index gynecologic cancer was higher than the risk in the general population (SIR 1.05, 95% CI 1.04 - 1.07). Organs especially at risk were Thyroid (SIR 1.45), Colon and Rectum (SIR 1.23), and Urinary System (SIR 1.33). Among women diagnosed with an index non-gynecologic cancer, 0.99% were diagnosed with a subsequent gynecologic cancer. The risk of developing a gynecologic cancer following a non-gynecologic cancer was also elevated compared to the average risk of the general population (SIR 1.05, 1.03 - 1.07), with uterine cancer having the highest SIR of 1.13.ConclusionThe risk of a developing a second primary cancer and the corresponding survival time is based on the order and site of the index and subsequent cancer. Surveillance guidelines should be examined further to optimize survivorship programs.

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Survival of Patients with First and Metachronous Second Primary Breast Cancer or Lung Cancer Malignancy: Comparisons Using the SEER Database

Cited by 6 publications

References 18 publications

Synchronous Malignancies Identified by PET-CT Scan in Breast Cancer Patients

Synchronous Malignancies Identified by PET-CT Scan in Breast Cancer Patients

Primary Lung Cancer After Treatment for Breast Cancer

Incidence and Survival of Multiple Primary Cancers in US Women With a Gynecologic Cancer

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