Survival of patients with bladder cancer after radical cystectomy

Комяков, Б. К.; Гулиев, Б Г; Сергеев, А. В.; Фадеев, В. А.; Ю, Ульянов А; Савашинский, Я С; Касьяненко, С. С.

doi:10.17650/1726-9776-2016-12-1-29-35

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…РМП характеризуется высокими темпами годового прироста заболеваемости и занимает одно из ведущих мест в структуре онкологической смертности в развитых странах мира, в том числе в России [1,2]. Высокий риск рецидива опухоли после органосохраняющего лечения [3,4], а также ограниченные возможности радикального лечения при местнораспространенных формах РМП [5][6][7] делают данное заболевание актуальной проблемой современной онкоурологии.…”

Section: Introductionunclassified

Subcutaneous and orthotopic xenograft models of human bladder carcinoma in nude mice for epidermal growth factor receptor-targeted treatment

Воронцова

Karmakova

Plotnikova

et al. 2018

Rossijskij bioterapevtičeskij žurnal

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Introduction.Approaches based on the principles of a targeted therapy are considered a promising strategy that is capable to improve the effectiveness of treatment for bladder cancer (BC) patients.The purposeof the study was to establish an orthotopic xenograft model of human BC in mice and to prove its suitability for experimental examination of drugs targeting the epidermal growth factor receptor (EGFR).Materials and methods.The objects of the study were ectopic subcutaneous and orthotopic human BC xenografts established using EJ and 5637 human BC cell lines. The growth of orthotopic xenografts in vivo was assessed by magnetic resonance imaging. Tumor tissues were investigated using histological and immunohistochemical techniques.Results.It was shown that EJ and 5637 xenografts exhibit a good reproducibility, a sufficient blood supply of the tumor tissues, a high level of EGFR expression, and different pattern of a subcellular receptor localization. Implantation and subsequent proliferation of human EJ or 5637 cells in the murine bladder mucosa presumably results in muscle-non-invasive tumor formation.Conclusions.The EJ and 5637 xenograft models can be useful for investigation of the efficacy of EGFR-targeted biotherapeutic treatments.

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Section: Introductionunclassified

Subcutaneous and orthotopic xenograft models of human bladder carcinoma in nude mice for epidermal growth factor receptor-targeted treatment

Воронцова

Karmakova

Plotnikova

et al. 2018

Rossijskij bioterapevtičeskij žurnal

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Patient survival after radical cystectomy

Ogorodnikova,

Mager,

Konstantinova

2023

Iv International Scientific Forum on Computer and Energy Sciences (Wfces Ii 2022)

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Local recurrences after radical cystectomy in bladder cancer patients

Komyakov

Saad

Фадеев

et al. 2023

Urology reports (St. - Petersburg)

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BACKGROUND: Radical cystectomy is the standard treatment for patients with muscle-invasive bladder cancer and superficial neoplasms in cases of resistance to intravesical immunochemotherapy. AIM: To establish the frequency of local pelvic recurrence in patients with bladder cancer after radical cystectomy. MATERIALS AND METHODS: From 1997 to 2022 radical cystectomy was performed in 407 patients with bladder cancer: 344 (84.5%) men and 63 (15.5%) women. Orthotopic urinary diversion methods were performed in 302 (74.2%) patients, including gastrocystoplasty 24 (5.9%), ileocystoplasty 253 (63.8%) and sigmocystoplasty 25 (6.1%) patients. Continent skin diversion of urine was performed in 13 (3.2%) patients, ureter transplantation into the sigmoid colon in 42 (10.3%) patients, and ureterocutaneostomy in 50 (12.3%) patients. RESULTS: Local recurrence in the pelvis after radical cystectomy was observed in 33 (8.1%) patients: 27 (81.8%) men and 6 (18.2%) women. The average age of men with relapses was 58.7 11.7 years (from 43 to 73 years), women 50.0 7.8 years (from 24 to 65 years). Simultaneous metastatic lesions of internal organs were detected in 6 (18.2%) patients. Local pelvic recurrence after radical cystectomy occurred more often in lymphopositive patients with extravesical spread of the primary low-grade tumor. The median time from radical cystectomy to detection of pelvic recurrence was 7.0 months, from the moment of detection of pelvic recurrence to the death of the patient 4.5 months. CONCLUSIONS: The frequency of local pelvic recurrence of bladder cancer after radical cystectomy is 8.1%. The survival rate of patients with local pelvic recurrence is extremely low.

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Survival of patients with bladder cancer after radical cystectomy

Cited by 4 publications

References 15 publications

Subcutaneous and orthotopic xenograft models of human bladder carcinoma in nude mice for epidermal growth factor receptor-targeted treatment

Subcutaneous and orthotopic xenograft models of human bladder carcinoma in nude mice for epidermal growth factor receptor-targeted treatment

Patient survival after radical cystectomy

Local recurrences after radical cystectomy in bladder cancer patients

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