Survival of Oral Human Immune Serum Globulin in the Gastrointestinal Tract of Low Birth Weight Infants

Blum, P; Phelps, Dale L.; Ank, Bonnie J.; Krantman, H J; Stiehm, E. Richard

doi:10.1203/00006450-198109000-00006

Cited by 80 publications

(35 citation statements)

References 7 publications

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“…This outcome is confirmed by our in vivo studies, in which quantitative comparison of ingested and recovered activity of antibody to rotavirus allowed us to conclude that rvl00J0 of the antiviral activity survived gastrointestinal passage. Similar results were reported by other authors, who showed the survival of human serum immunoglobulins after being orally administered to low-birth-weight infants [38] and the conservation of specific antitoxic activity of bovine milk immunoglobulins in in vitro and in vivo digestion trials in rabbits [39]. Our results show that orally ad- We found appreciable amounts of neutralizing activity against human rotaviruses in the stools of concentrate C-treated infants.…”

Section: S a Plotkin Personal Communication)supporting

confidence: 91%

Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants

Hilpert

Briissow

Mietens

et al. 1987

Journal of Infectious Diseases

187

110

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The use of a concentrate containing milk immunoglobulins prepared from rotavirushyperimmunized cows (neutralization titer, 1:6,000 for a 10070 solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = . (08) reduction in the duration of excretion of virus. Stool samples from treated infants showed the presence of bovine milk immunoglobulins in 47% of cases and of neutralizing activity in 43% (mean neutralization titer, 1:48); stool samples from control infants showed neutralizing activities in only 30J0 of cases (neutralization titers, <1:20). Immunoelectrophoresis of stool extracts revealed fragment A, a bovine analogue of Ftab'), or Fab, as the major product of in vitro and in vivo digestion of the immunoglobulins. Cessation of excretion of virus correlated with the appearance of neutralizing activities in 19 of 25 infants. Only concentrate-treated infants with high neutralizing activity in stools showed a statistically significant reduction in duration of excretion of virus; this duration in concentrate-treated infants with low neutralizing activity was comparable with controls.

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Section: S a Plotkin Personal Communication)supporting

confidence: 91%

Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants

Hilpert

Briissow

Mietens

et al. 1987

Journal of Infectious Diseases

187

110

View full text Add to dashboard Cite

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“…Orally administered Ig appears to be at least partially resistant to digestion in the GIT and intact active Ig has been -E-mail: p.j.moughan@massey.ac.nz reported in the stools of low birth weight infants given Ig orally (Blum et al, 1981). Roos et al (1995) demonstrated that as much as 19% of ingested IgG and IgM remain immunologically active in the intestine of adult humans.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with ovine serum immunoglobulin attenuates acute effects on growth, organ weights, gut morphology and intestinal mucin production in the growing rat challenged with Salmonella enteritidis

Balan

Han

Rutherfurd

et al. 2011

Animal

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The aim was to determine the effect of orally administered ovine serum immunoglobulin (Ig) on growth performance, organ weight, gut morphology and mucin production in the Salmonella enteritidis -gavaged growing rat. Four groups consisted of non-gavaged rats fed a casein-based control basal diet (BD) and three groups of rats gavaged with 1 3 10 7 CFU S. enteritidis and fed a casein-based diet, a diet containing freeze-dried ovine Ig (FDOI) or a casein-based diet containing inactivated ovine Ig (IOI). The rats were randomly allocated to one of the four groups (n 5 15/group) and received their respective diets for an 18-day experimental study. Gavaging took place on day 15. Average daily gain and body gain : feed ratio (post-gavage, 3 days) were significantly (P , 0.05) higher for the Salmonella-challenged rats fed the FDOI diet compared to those fed the BD and IOI diets. At the end of the study, the small intestine and colon were significantly (P , 0.05) heavier for the gavaged rats fed the FDOI diet compared to the gavaged rats fed either the BD or IOI diet. Moreover, the relative weights of the caecum, liver and spleen of the gavaged rats fed the BD or IOI diet were significantly (P , 0.05) heavier compared to the gavaged rats fed the FDOI diet. Generally, the gavaged rats fed the FDOI diet had significantly (P , 0.05) higher goblet cell counts and luminal mucin protein contents than the gavaged rats fed either the BD or IOI diet and had a more functional gut morphology. Overall, the FDOI fraction prevented the acute effects of S. enteritidis.

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“…However, problems ofavailability, storage, and the possible transmission of infectious agents, such as cytomegalovirus, are factors that make widespread treatment or prophylaxis trials with human milk products difficult to accomplish. There have been several studies in man suggesting that passive immunity against infectious diarrheal agents may be achieved by the oral administration of immunoglobulin preparations derived from human or animal sera (12)(13)(14). To date, there have been no detailed studies of orally administered immunoglobulins in humans older than 13 wk ofage or in patients with chronic infectious diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis.

et al. 1985

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We examined the pharmacokinetics and immunological activity of human serum immunoglobulins (HSG) possessing anti-rotavirus activity which were orally administered to three children with primary immunodeficiency syndromes and prolonged gastrointestinal excretion of rotavirus. Detailed analysis of the excretion of immunoglobulins labeled with biotin or I"25 revealed that -50% of the recovered radioactivity was excreted in the stools over a 3-d period. Approximately half of the excreted radioactivity recovered in the stool was in a macromolecular form with immunological activity. The remainder of the recovered radioactivity was excreted in the urine as low molecular weight fragments or free iodide. In addition, immunological and chromatographic analyses revealed that the oral administration of HSG resulted in the generation of rotavirus-specific immune complexes in the gastrointestinal tract with a subsequent decrease in the presence of uncomplexed rotavirus antigen. These studies indicate that orally administered HSG can survive passage in the gastrointestinal tract in an immunologically active form, and that the oral administration of immunoglobulins with specific reactivities has potential for the prevention or treatment of gastrointestinal infections.

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Survival of Oral Human Immune Serum Globulin in the Gastrointestinal Tract of Low Birth Weight Infants

Cited by 80 publications

References 7 publications

Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants

Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants

Dietary supplementation with ovine serum immunoglobulin attenuates acute effects on growth, organ weights, gut morphology and intestinal mucin production in the growing rat challenged with Salmonella enteritidis

Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis.

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