Survival of differentiated thyroid carcinoma studied in 500 patients.

Lerch, H; Schober, Otmar; Kuwert, Torsten; Saur, H.-B.

doi:10.1200/jco.1997.15.5.2067

Cited by 129 publications

(90 citation statements)

References 28 publications

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“…This discrepancy could be the result of etiologic differences that correlate with geography, as reported 10-year and 20-year DSS from Sweden, Germany, and Austria, where goiter is endemic or prevented by iodide substitution, were similar or worse compared with this study. 3,9,38,39 Whereas tumor size (median 50 mm) was slightly higher, the age distribution, which was a major risk factor, was similar in our cohort (median age, 41.3 years in the PTC group) with those reported from countries without endemic goiter (United States, Asia). Studies from regions with endemic goiter, show that the proportion of FTC in patients with WDTC is higher in these regions.…”

Section: Survivalsupporting

confidence: 58%

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

et al. 2009

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Background. Papillary or follicular thyroid carcinomas exhibit a relatively benign course. Hence, long-term follow-up studies with well-defined disease stages and treatment details are needed to evaluate treatment strategies. Methods. Patients who underwent complete resection of well-differentiated thyroid carcinoma (WDTC) confined to the thyroid gland between 1972 and 1990 identified from a prospective database were assessed. Follow-up was performed by interview, review of patient charts, and analysis of the Death Registry. Primary endpoints were overall survival (OS) and disease-specific survival (DSS). Review of histology was performed and extent of thyroid resection, postoperative therapy, and recognized prognostic factors but not lymphadenectomy were evaluated. Results. Of 2,867 patients, 213 had complete resection of WDTC confined to the thyroid gland. Follow-up was completed in 166 patients with median age 54.2 (range, 20-85) years, and median follow-up of 27.2 (range, 15.6-34.5) years. The 10-and 20-year OS was 71 and 55%, respectively. DSS at 10 and 20 years was 81 and 69%, respectively, and correlated with age, histology, tumor size, radio-iodide ablation (RIA), and external beam irradiation (EBR) treatment. No patient died of WDTC more than 18 years after resection. Total or near-total thyroidectomy without lymphadenectomy was not superior to partial thyroidectomy. In multivariate analysis for DSS, age was the dominant factor, which correlated with histology.

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Section: Survivalsupporting

confidence: 58%

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

et al. 2009

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“…Children and people younger than 20 years tend to present with higher stage disease and greater likelihood of locoregional and distant metastases, despite it, children generally have excellent survival rates, the exception to this rule is the disease in children aged < 10 years (Sipos & Mazzaferri, 2010). In the same line as most of the studies (Beenken et al, 2000;Eichhorn et al, 2003;Gilliland et al, 1997;Lerch et al, 1997;Mazzaferri, 1999;Shah et al, 1992), we found that the presence of distant metastases at presentation is an independent risk factor in the prognosis of differentiated thyroid carcinoma. The main cause of death from differentiated thyroid cancer is distant metastases (Mazzaferri, 1993).…”

Section: Discussionsupporting

confidence: 78%

An Epidemiological Analysis of Thyroid Cancer in a Spanish Population: Presentation, Incidence and Survival

Rego-Iraeta¹,

Pérez-Méndez²,

García‐Mayor³

2012

Updates in the Understanding and Management of Thyroid Cancer

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“…The other nine systems were either derived from DTC (i.e. PTC and FTC together; Cady & Rossi 1988, Mazzaferri & Jhiang 1994, Shaha et al 1994, Lerch et al 1997, Beeken et al 2000, Greene et al 2002, Yildirim 2005 or derived from all histologic types of thyroid carcinoma, including medullary and anaplastic thyroid carcinoma (Byar et al 1979, Sherman et al 1998. Interestingly, there was only one of the 18 systems (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Figure 8 shows CSS of 171 patients by the GAMES system. University of Mü nster (Mü nster; Lerch et al 1997) This system was published in 1995 after an analysis of 500 DTC patients. Of note, this series comprised a high proportion of FTC (almost 40%).…”

Section: B H-h Lang Et Al: Staging For Follicular Thyroid Carcinomamentioning

confidence: 99%

Staging systems for follicular thyroid carcinoma: application to 171 consecutive patients treated in a tertiary referral centre

Lang¹,

Lo²,

Chan³

et al. 2007

Endocr Relat Cancer

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A number of risk-group stratification or staging systems have been found useful at stratifying patients with differentiated thyroid carcinoma into risk groups. Those identified as high risk could be subjected to more aggressive treatment, while those at low risk could be spared of such treatment. However, the best stratification system in patients with follicular thyroid carcinoma (FTC) remains unclear. Through a comprehensive MEDLINE search from 1965 to 2005, a total of 18 different staging systems were identified in the literature and 14 of them were applicable to 171 patients, with FTC managed at our institution from 1961 to 2001. Cancer-specific survivals (CSS) were calculated by Kaplan-Meier method and were compared by log-rank test. Using Cox proportional hazards analysis, the relative importance of each staging system in determining CSS was calculated by the proportion of variation in survival time explained (PVE). CSS were predicted by 13 out of the 14 staging systems significantly (P!0.001). The three highest ranked staging systems by PVE were the new American Joint Commitee on Cancer/Union Internationale Centre le Cancer 6th edition, tumour, node, metastases (TNM; 22.4), followed by the Clinical Class (21.2) and the metastases, age, completeness of resection, invasion, size (MACIS; 20.4). In conclusion, 13 out of the 14 presently available staging systems predicted CSS significantly in FTC. When predictability was measured by PVE, the TNM system was found to have the best predictability and thus, should be the stratification system of choice for FTC in the future.

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Survival of differentiated thyroid carcinoma studied in 500 patients.

Abstract: In differentiated thyroid carcinoma, the use of total surgical thyroidectomy followed by high-dose radioiodine therapy and early surgical reintervention in case of locoregional recurrence yields high survival rates, even without adjuvant external radiotherapy of the neck.

Cited by 129 publications

References 28 publications

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

An Epidemiological Analysis of Thyroid Cancer in a Spanish Population: Presentation, Incidence and Survival

Staging systems for follicular thyroid carcinoma: application to 171 consecutive patients treated in a tertiary referral centre

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