Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia

Duarte, Carlos; Flórez, JP; López, Héctor; Meneses, María Ximena; Vries, Esther de

doi:10.1111/jdv.13913

Cited by 27 publications

(39 citation statements)

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“…Our findings concur with previous publications which have evaluated ALM patients in according to ethnicity (Caucasians and other ethnic groups, such as blacks, Hispanics, and Asians) in the same studies [1, 2, 4, 5, 8] and in separate studies [3, 6, 7]. In 17 population-based cancer registries, with a total number of 1,413 American subjects with histologically confirmed cases of ALM, the proportion of ALM among all melanoma subtypes was greatest in nonwhites, accounting for 36% of all melanomas in blacks, 18% in Asian/Pacific Islanders, 9% in Hispanic whites, and only 1% in non-Hispanic whites [1].…”

Section: Discussionsupporting

confidence: 81%

“…Phan et al [3] found that the prognosis of ALM in Whites was poor; the 5-year survival rate was 76%. Similar unfavorable survival results emerged from other studies in Hispanic patients [4, 5]. The 5-year overall survival of 90 Colombian ALM patients was only 54% [4], and ALM was an independent risk factor for decreased survival in Mexican melanoma patients ( p = 0.004) [5].…”

Section: Discussionsupporting

confidence: 66%

“…Similar unfavorable survival results emerged from other studies in Hispanic patients [4, 5]. The 5-year overall survival of 90 Colombian ALM patients was only 54% [4], and ALM was an independent risk factor for decreased survival in Mexican melanoma patients ( p = 0.004) [5]. The reduced survival rates in those 2 studies were attributed to the advanced stages at presentation.…”

Section: Discussionsupporting

confidence: 63%

“…Since ALM rarely occurs in Caucasians and it is the most common type of melanoma in people with darker skin, a large number of papers on ALM have been published from Hispanic [4, 5] and Far East countries [6, 7]. A total of 90 Colombian ALM patients (55 men and 35 women) were investigated in a retrospective study [4].…”

Section: Discussionmentioning

confidence: 99%

“…A total of 90 Colombian ALM patients (55 men and 35 women) were investigated in a retrospective study [4]. Of those patients, 80 had lower-limb lesions, 59 of which were plantar.…”

Section: Discussionmentioning

confidence: 99%

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Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival

Taş¹,

Ertürk²

2018

Pathobiology

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Background/Aims: Acral lentiginous melanoma (ALM) is a small subtype of melanoma affecting Caucasians far more often than other ethnic groups, such as blacks, Hispanics, and Asians. Only a few studies have yielded controversial results on ALM so far. The aim of this study was to define the histopathological and clinical expressions of ALM and to compare them with those of non-ALM in a large group of Turkish patients from a single referral institution. Methods: One hundred two ALM patients were analyzed retrospectively. Results: The median age of the patients was 58 years. The lower limbs (the thigh and leg as well as the foot) were predominantly affected (78%) and cases were mostly nonungual (89%). ALM were found more frequently in females (p = 0.04). They were ulcerated (p = 0.0001), they were associated with neurotropism (p = 0.0001), they lacked the BRAF mutation (p = 0.03), and they less often coexisted with a preceding melanocytic nevus (p = 0.0001). No correlations were found between ALM and either nodal involvement or distant metastasis. The recurrence-free survival and overall survival rates for ALM patients were similar to those of patients with other histopathologies. The 5-year recurrence-free survival and 5-year overall survival rates for ALM patients were 58.7 and 59%, respectively. Conclusion: Although ALM is associated with some aggressive histopathological factors, it may not correlated with nodal involvement, recurrence, or poor survival.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

“…A total of 90 Colombian ALM patients (55 men and 35 women) were investigated in a retrospective study [4]. Of those patients, 80 had lower-limb lesions, 59 of which were plantar.…”

Section: Discussionmentioning

confidence: 99%

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Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival

Taş¹,

Ertürk²

2018

Pathobiology

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Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

Yoshikawa²,

et al. 2019

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Background The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large‐scale Asian studies that include follow‐up data have been reported. Objectives To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan‐Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease‐specific survival in patients with invasive melanoma. Results In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4%) followed by superficial spreading melanoma (20.5%), nodular melanoma (10.0%), mucosal melanoma (9.5%), and lentigo maligna melanoma (8.1%). The 5‐year disease‐specific survival for each stage was as follows: IA = 98.0%, IB = 93.9%, IIA = 94.8%, IIB = 82.4%, IIC = 71.8%, IIIA = 75.0%, IIIB = 61.3%, IIIC = 41.7%, and IV = 17.7%. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions Our study revealed the characteristics of melanoma in the Japanese population. The 5‐year disease‐specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.

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Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes

Lin,

Sun,

Ren

et al. 2023

Journal of Surgical Oncology

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BackgroundMetastasis in a nonsentinel lymph node (non‐SLN) is an unfavorable independent prognostic factor in cutaneous melanoma (CM). Recent data did suggest potential value of completion lymph node dissection (CLND) in CM patients with non‐SLN metastasis. Prediction of non‐SLN metastasis assists clinicians in deciding on adjuvant therapy without CLND. We analyzed risk factors and developed a prediction model for non‐SLN status in acral melanoma (AM).MethodsThis retrospective study enrolled 656 cases of melanoma who underwent sentinel lymph node biopsy at Fudan University Shanghai Cancer Center from 2009 to 2017. We identified 81 SLN + AM patients who underwent CLND. Clinicopathologic data, including SLN tumor burden and non‐SLN status were examined with Cox and Logistics regression models.ResultsUlceration, Clark level, number of deposits in the SLN (NumDep) and maximum size of deposits (MaxSize) are independent risk factors associated with non‐SLN metastases. We developed a scoring system that combines ulceration, the cutoff values of Clark level V, MaxSize of 2 mm, and NumDep of 5 to predict non‐SLN metastasis with an efficiency of 85.2% and 100% positive predictive value in the high‐rank group (scores of 17–24).ConclusionsA scoring system that included ulceration, Clark level, MaxSize, and NumDep is reliable and effective for predicting non‐SLN metastasis in SLN‐positive AM.

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Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia

Cited by 27 publications

References 15 publications

Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival

Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes

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