Survival in Synchronous vs Single Lung Cancer

Rens, Marcel Th. M. van; Zanen, Pieter; Rivière, Aart Brutel de la; Elbers, Hans R.J.; Swieten, Henry A. van; Bosch, Jules M.M. van den

doi:10.1378/chest.118.4.952

Cited by 72 publications

(46 citation statements)

References 20 publications

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“…2). This result is in line with other reports [37]. Aziz et al showed that a 5-year survival of patients with lung cancer as a new malignancy amounted to 44% as compared to 10% for patients with synchronous cancers [38].…”

Section: Discussionsupporting

confidence: 93%

Impact of smoking on multiple primary cancers survival: a retrospective analysis

2018

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According to available literature, active tobacco smoking enhances the risks of recurrence and development of new primary malignancies. Smoking also shortens the survival period for patients with a diagnosed neoplastic disease. Medical records of 1622 patients hospitalized at the Center for Pulmonary Diseases from January 2013 till March 2017 were retrospectively analyzed, out of which 741 cases with a diagnosis of at least one primary cancer were selected, including 111 patients with multiple primary malignancies. Survival time, the impact of smoking on cancer development and the influence of smoking cessation on the prognosis of the development of new malignancies were analyzed. The incidence of multiple primary malignancies in the population of cancer patients amounted to 14.98%. In the group of smokers, those who ceased smoking developed the second primary malignancy later as compared to those who did not: the period between the first and the new cancer was 11.55 years (SD 7.24) for those who quit smoking, whereas for those who continued to smoke after their first cancer diagnosis it was 6.10 years (SD 8.62) (p = 0.005). It was revealed that patients who had never smoked lived longer than those who had continued to smoke (p = 0.004) and that those who had ceased smoking had a longer survival time than those who had not (p = 0.027). Ceasing smoking after the first cancer diagnosis prolongs the time before a new malignancy develops and is diagnosed, as well as the total survival time after the first cancer diagnosis.

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Section: Discussionsupporting

confidence: 93%

Impact of smoking on multiple primary cancers survival: a retrospective analysis

2018

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“…A study reports that in synchronous tumors, the tumor with the most advanced stage is the best predictor for survival. [7] Studies state that multiple pulmonary lesions have to be elucidated histopathologically because of the risk of synchronous tumors, and aggressive surgery in the early stages is necessary. [8] The American College of Chest Physicians guidelines for synchronous lung cancers state that following invasive mediastinal staging and extrathoracic imaging, every single tumor should be removed unless there is enough pulmonary reserve and no N2 involvement.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Three Malignancies: Two Different Lung Cancers Synchronous with Lymphoma

Ogan¹

2017

TJ Oncol

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SUMMARYEpithelial tumors synchronous with hematologic malignancies are very rare. The hystopathologic type and stage of synchronous tumors are very important for prognosis. A 77-year-old male patient was diagnosed with lymphoma after an excisional biopsy was taken from the retroauricular region. Positron emission tomography, performed for lymphoma staging, revealed a positive solid nodule (SUVmax: 24.3) in the posterobasal segment of the right lower lobe and a negative subsolid nodule in the anterior segment of the upper lobe. Right lower lobectomy and wedge resection for subsolide nodule in the upper lobe were performed. Histopathological examination revealed mildly differentiated squamous cell carcinoma for the solid nodule and mildly differentiated adenocarcinoma with lepidic pattern for the subsolid nodule. The patient was treated for only lymphoma according to the decision of the tumor board, and his condition is stable for 1 year without any evidence of lung cancer recurrence. This case presents the treatment approach and the fact that triple synchronic malignant cases are rare in the literature.

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“…Surgical treatment is recommended for patients with tumors meeting resectability criteria. [10] In eligible patients with ipsilateral synchronous tumors, anatomical resection of any type, including pneumonectomy, can be applied. However if the tumors are bilateral, then a consecutive surgical treatment protocol is applied at an interval of 4 to 6 weeks, starting with the resection of the higher-stage tumor.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Synchronous Multiple Primary Lung Cancer: Report of Two Cases

Demirhan¹

2017

South Clin Ist Euras

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Survival in Synchronous vs Single Lung Cancer

Cited by 72 publications

References 20 publications

Impact of smoking on multiple primary cancers survival: a retrospective analysis

Impact of smoking on multiple primary cancers survival: a retrospective analysis

Coexistence of Three Malignancies: Two Different Lung Cancers Synchronous with Lymphoma

Surgical Treatment of Synchronous Multiple Primary Lung Cancer: Report of Two Cases

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