Survival in Patients With Poorly Compressible Leg Arteries

Arain, Faisal A.; Ye, Zi; Bailey, Kent R.; Chen, Qian; Liu, Guanghui; Leibson, Cynthia L.; Kullo, Iftikhar J.

doi:10.1016/j.jacc.2011.09.055

Cited by 69 publications

(41 citation statements)

References 35 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not find any association with stroke or mortality. Several other prospective studies have reported associations with total and cardiovascular mortality and combined cardiovascular events, 7,13,[18][19][20] with substantially larger adjusted effect sizes than ours. Although different populations have been studied and this may underlie certain differences, a mechanistic explanation is not evident.…”

Section: Discussioncontrasting

confidence: 74%

Association of High Ankle Brachial Index With Incident Cardiovascular Disease and Mortality in a High-Risk Population

Hendriks

Westerink

Jong

et al. 2016

ATVB

View full text Add to dashboard Cite

Objective— The objective of this present study is to determine whether high ankle brachial index (ABI) as compared with ABIs within reference limits is associated with an increased incidence of cardiovascular disease (CVD) events and all-cause mortality in a high-risk population and whether this association is the same for patients with and without diabetes mellitus or prevalent CVD. Approach and Results— Seven thousand five hundred and thirty-eight patients with ABI>0.9 and either prevalent CVD or a high risk for CVD were selected from the Second Manifestations of Arterial Disease (SMART) study. Three hundred and thirty-six participants (4.5%) had high ABI (≥1.4 or incompressible). Higher age, male sex, higher body mass index, and diabetes mellitus were associated with higher prevalences of high ABI; smoking and higher non–high-density lipoprotein levels were associated with lower prevalences of high ABI. Cox proportional hazards models were fitted assessing the association of high ABI (as compared with ABI 0.9–1.4) with the risk of myocardial infarction, stroke, cardiovascular death, the combined outcome of these 3, and total mortality (median follow-up 6.9 years). After multivariable adjustment, high ABI was associated with an increased risk of myocardial infarction (hazard ratio 1.83 [95% confidence interval 1.22–2.76]), but not with stroke (hazard ratio 0.86 [95% confidence interval 0.44–1.69]), cardiovascular (hazard ratio 1.14 [95% confidence interval 0.70–1.84]), or all-cause mortality (hazard ratio 0.95 [95% confidence interval 0.67–1.34]). Associations of high ABI with CVD outcomes tended to be stronger in patients with diabetes mellitus but without statistically significant interactions. Conclusions— In a high-risk population, the presence of an ABI≥1.4 was associated with an increased risk for myocardial infarction, but not with stroke, all-cause, or vascular mortality.

show abstract

Section: Discussioncontrasting

confidence: 74%

Association of High Ankle Brachial Index With Incident Cardiovascular Disease and Mortality in a High-Risk Population

Hendriks

Westerink

Jong

et al. 2016

ATVB

View full text Add to dashboard Cite

show abstract

“…157 In contrast, a report from the Mayo Clinic vascular laboratory showed an independent risk for a high ABI that was further increased in the presence of underlying PAD. 158 Further studies on this question are needed.…”

Section: -144mentioning

confidence: 99%

Epidemiology of Peripheral Artery Disease

Criqui

Aboyans

2015

Circulation Research

1,264

921

View full text Add to dashboard Cite

New data on the epidemiology of peripheral artery disease (PAD) are available, and they should be integrated with previous data. We provide an updated, integrated overview of the epidemiology of PAD, a focused literature review was conducted on the epidemiology of PAD. The PAD results were grouped into symptoms, diagnosis, prevalence, and incidence both in the United States and globally, risk factors, progression, coprevalence with other atherosclerotic disease, and association with incident cardiovascular morbidity and mortality. The most common symptom of PAD is intermittent claudication, but noninvasive measures, such as the anklebrachial index, show that asymptomatic PAD is several times more common in the population than intermittent claudication. PAD prevalence and incidence are both sharply age-related, rising >10% among patients in their 60s and 70s. With aging of the global population, it seems likely that PAD will be increasingly common in the future. Prevalence seems to be higher among men than women for more severe or symptomatic disease. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease, with some differences in the relative importance of factors. Smoking is a particularly strong risk factor for PAD, as is diabetes mellitus, and several newer risk markers have shown independent associations with PAD. PAD is strongly associated with concomitant coronary and cerebrovascular diseases. After adjustment for known cardiovascular disease risk factors, PAD is associated with an increased risk of incident coronary and cerebrovascular disease morbidity and mortality.

show abstract

“…A recent study showed that individuals with an ABI > 1.4 have a worse prognosis than those with a normal ABI and even those with an ABI < 0.9. The prevalence of diabetes in the group with an ABI > 1.4 was 58%, compared with 18% and 48% in those with a normal ABI or those with an ABI < 0.9 [37] . It has long been known that the sensitivity of the ABI to correctly diagnose PAD is considerably reduced in the presence of arterial media calcification and that, clinically, this calcification is associated with the presence of peripheral neuropathy [38,39] .…”

Section: Diagnosis Of Pad In Diabetesmentioning

confidence: 82%