Survival in patients with medullary thyroid cancer after less than the recommended initial operation

Randle, Reese W.; Bates, Maria F.; Sippel, Rebecca S.; Pitt, Susan C.

doi:10.1002/jso.24954

Cited by 17 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another weak predictor of adverse outcome was male sex ( p = 0.005). Contradictory results have been found in other studies (8,10,12). To the best of the authors' knowledge, only one research group has previously reported male sex as a significant predictor ( p = 0.0001) for disease-specific mortality at a population level (11).…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997–2014: A Nationwide Study

Mathiesen

Kroustrup

Vestergaard

et al. 2019

Thyroid

View full text Add to dashboard Cite

Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5–4.3]), patients without regional metastases (HR = 1.4 [CI 0.9–2.3]), and patients with stage I (HR = 1.3 [CI 0.6–3.1]), stage II (HR = 1.1 [CI 0.6–2.3]), and III (HR = 1.3 [CI 0.4–4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0–25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0–133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure.

show abstract

Section: Discussionsupporting

confidence: 80%

“…Disease-specific survival of MTC patients is strongly dependent on the age and stage at diagnosis. This has been well recognized for decades (8–13). The significance of sex as a prognostic factor, however, remains controversial (8,10–13).…”

Section: Introductionmentioning

confidence: 92%

Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997–2014: A Nationwide Study

Mathiesen

Kroustrup

Vestergaard

et al. 2019

Thyroid

View full text Add to dashboard Cite

show abstract

“… 23 , 32 , 33 In a retrospective study, patients with T1 tumors had no difference in 5-year survival, regardless of whether they underwent total thyroidectomy. 34 The same result was also reported in patients with T2 tumors, although the follow-up time was shorter. 34 Hamdy et al 2 reported that both the presence of LNM and the involved side were predictors of prognosis.…”

Section: Discussionsupporting

confidence: 74%

Clinical Characteristics, Surgical Management, and Prognostic Factors of Medullary Thyroid Carcinoma: A Retrospective, Single-Center Study

Zheng

2022

Technol Cancer Res Treat

View full text Add to dashboard Cite

Purpose: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy with relatively early lymphatic metastatic spread. The clinical features of MTC remain controversial owing to the low incidence rate. This study aimed to analyze the clinical characteristics, prognostic factors, and long-term follow-up of MTC. Methods: Medical records of MTC patients treated at our hospital between December 2000 and November 2020 were reviewed retrospectively. Clinicopathologic features of MTC were analyzed using univariate and multivariate analyses. Cumulative survival rates were estimated using the Kaplan-Meier method. Results: In total, 152 patients with MTC were included. The rates of central and lateral lymph node metastases (LNM) were 52.0% and 42.8%, respectively. All patients were followed up with a median follow-up time of 43.5 (17.0−76.3) months. Univariate and multivariate analyses identified two independent factors associated with progressive disease. They were lateral LNM (p < 0.001) and lymph node ratio (LNR) >1/3 (p = 0.009). The 5-, 10-, and 15-year cumulative overall survival (OS) rates of MTC were 88.2%, 83.1%, and 76.2%, respectively. The 5-, 10-, and 15-year cumulative disease-free survival (DFS) rates were 61.8%, 48.6%, and 38.2%, respectively. Patients with stage I, II, and III disease had significantly longer OS and DFS than those with stage IV disease (p < 0.001). Conclusion: MTC is a rare endocrine malignancy and LNM is common. Patients with lateral LNM and LNR >1/3 are more likely to develop progressive disease. The long-term OS rates of MTC are good, but long-term DFS rates are poor.

show abstract

“…They have been widely used in multiple malignancies due to their ability to handle complexity in a systematic, unbiased manner 16–18. Although some studies have reported risk factors associated with survival in patients with MTC,7,19 single prognostic factor shows limited utility in prediction of individual survival probability. Few studies have created a prognostic model for this disease.…”

Section: Discussionmentioning

confidence: 99%

“…However, this system cannot be used for predicting individual patient outcomes. Moreover, some other factors including age, tumor size, extrathyroidal extension, margin status, vascular invasion, and calcitonin may be important for determining outcomes in individual patients 7,8. Therefore, it is needed to establish a prognostic indicator system specified for MTC patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Development and validation of prognostic nomograms for medullary thyroid cancer</p>

Guan¹,

Fang²,

Chen

et al. 2019

OTT

View full text Add to dashboard Cite

Background This aim of study was to develop and validate clinical nomograms to predict the survival of patients with medullary thyroid cancer. Patients and methods Patient data were collected from the Surveillance, Epidemiology, and End Results database between 2004 and 2013. All included patients were randomly assigned into the training and validation sets. Multivariate analysis using Cox proportional hazards regression was performed, and nomograms were constructed. Model performance was evaluated by discrimination and calibration plots. Results A total of 1,657 patients were retrospectively analyzed. The multivariate Cox model identified age, tumor size, extrathyroidal extension, N stage, and M stage as independent covariates associated with overall survival (OS) and cancer-specific survival (CSS). Nomograms predicting OS and CSS were constructed based on these covariates. The nomograms predicting both OS and CSS exhibited superior discrimination power to that of TNM staging system in the training and validation sets. Calibration plots indicated that both the nomograms in OS and CSS exhibited high correlation to actual observed results. Conclusion The nomograms established in this study provided an alternative tool for prognostic prediction, which may thereby improve individualized assessment of survival risks and lead to the creation of additional clinical therapies.

show abstract

Survival in patients with medullary thyroid cancer after less than the recommended initial operation

Abstract: According to population-based SEER registry data, the extent of initial resection may not significantly change DSS in patients with MTC confined to the central neck.

Cited by 17 publications

References 24 publications

Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997–2014: A Nationwide Study

Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997–2014: A Nationwide Study

Clinical Characteristics, Surgical Management, and Prognostic Factors of Medullary Thyroid Carcinoma: A Retrospective, Single-Center Study

<p>Development and validation of prognostic nomograms for medullary thyroid cancer</p>

Contact Info

Product

Resources

About