Survival in pancreatic cancer: the best is yet to come

Sauer, Bryan G.; Shami, Vanessa M.

doi:10.1016/j.gie.2010.02.049

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Better treatment can contribute to a significant improvement in patient survival [2]. Intraoperative consultation which mainly involves the examination of the surgical excised specimen, is important for the surgeon to determine the most appropriate treatment options [3].…”

Section: Introductionmentioning

confidence: 99%

Nonlinear Optical Microscopy for Histology of Fresh Normal and Cancerous Pancreatic Tissues

Zhao

Wang

et al. 2012

PLoS ONE

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BackgroundPancreatic cancer is a lethal disease with a 5-year survival rate of only 1–5%. The acceleration of intraoperative histological examination would be beneficial for better management of pancreatic cancer, suggesting an improved survival. Nonlinear optical methods based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) of intrinsic optical biomarkers show the ability to visualize the morphology of fresh tissues associated with histology, which is promising for real-time intraoperative evaluation of pancreatic cancer.Methodology/Principal FindingsIn order to investigate whether the nonlinear optical imaging methods have the ability to characterize pancreatic histology at cellular resolution, we studied different types of pancreatic tissues by using label-free TPEF and SHG. Compared with other routine methods for the preparation of specimens, fresh tissues without processing were found to be most suitable for nonlinear optical imaging of pancreatic tissues. The detailed morphology of the normal rat pancreas was observed and related with the standard histological images. Comparatively speaking, the preliminary images of a small number of chemical-induced pancreatic cancer tissues showed visible neoplastic differences in the morphology of cells and extracellular matrix. The subcutaneous pancreatic tumor xenografts were further observed using the nonlinear optical microscopy, showing that most cells are leucocytes at 5 days after implantation, the tumor cells begin to proliferate at 10 days after implantation, and the extracellular collagen fibers become disordered as the xenografts grow.Conclusions/SignificanceIn this study, nonlinear optical imaging was used to characterize the morphological details of fresh pancreatic tissues for the first time. We demonstrate that it is possible to provide real-time histological evaluation of pancreatic cancer by the nonlinear optical methods, which present an opportunity for the characterization of the progress of spontaneous pancreatic cancer and further application in a non-invasive manner.

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Section: Introductionmentioning

confidence: 99%

Nonlinear Optical Microscopy for Histology of Fresh Normal and Cancerous Pancreatic Tissues

Zhao

Wang

et al. 2012

PLoS ONE

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Long-term trends in the incidence and relative survival of pancreatic cancer in Canada: A population-based study

2016

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Pancreatic cancer: A guide for practice nurses

Perry¹

2018

Practice Nursing

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Although rare, pancreatic cancer usually has a poor prognosis. Margaret Ann Perry explains the risk factors for, and diagnosis and treatment of, the disease Despite improved survival for those with many types of cancer, pancreatic cancer has continued to have poor outcomes. This article was written following the loss of a popular and well respected colleague who recently passed away from this devastating disease. It aims to alert practice nurses to the vague symptoms of pancreatic cancer, its diagnosis and management, and improve knowledge and understanding of this much-feared cancer type.

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Survival in pancreatic cancer: the best is yet to come

Cited by 3 publications

References 14 publications

Nonlinear Optical Microscopy for Histology of Fresh Normal and Cancerous Pancreatic Tissues

Nonlinear Optical Microscopy for Histology of Fresh Normal and Cancerous Pancreatic Tissues

Long-term trends in the incidence and relative survival of pancreatic cancer in Canada: A population-based study

Pancreatic cancer: A guide for practice nurses

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