Survival in ANCA-Associated Vasculitides in a Peruvian Center

Abstract

The aim of this study was to identify demographic and clinical risk factors for mortality in patients with antineutrophil cytoplasmic antibodies-associated vasculitides (AAVs) in a Peruvian tertiary referral hospital.Methods: Medical records of patients with AAVaccording to classification criteria or diagnosed by an experienced rheumatologist, covering the period between January 1990 and December 2018, were reviewed. Granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and renal-limited vasculitis were included. Potential predictors of mortality were demographic factors, clinical manifestations, antineutrophil cytoplasmic antibodies status, diagnosis, disease categorization, the 2009 Five Factor Score (FFS), and treatment. Cox regression models were used to determine the risk factors for mortality. Univariable and multivariable analyses using a backward selection method were performed.Results: One hundred ninety-six patients were included; female-to-male ratio was 2:1. The median (interquartile range) age at diagnosis and follow-up were 60.0 (51.0-68.0) and 4.8 (1.3-11.6) years, respectively. One hundred forty-eight patients (75.5%) had microscopic polyangiitis, 37 (18.9%) granulomatosis with polyangiitis, 5 (2.6%) eosinophilic granulomatosis with polyangiitis, and 6 (3.0%) renal-limited vasculitis. Overall survival rates at 1, 5, and 10 years were 83.4%, 68.2%, and 51.7%, respectively. Ocular involvement was protective (hazards ratio [HR], 0.

Performance of the 2017 American College of Rheumatology/European League Against Rheumatism Provisional Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in a Peruvian Tertiary Care Center

“…The characteristics of the patients and their predictive factors of survival have been described in detail in previous publications. 6,7 We performed a review of the medical records of patients with AAV followed at this clinic between January 1990 and December 2019. Antineutrophil cytoplasmic antibody-associated vasculitis was diagnosed by experienced rheumatologists based on the 1990 ACR criteria, the 2012 CHCC definitions, the EMEA algorithm, and their experience and clinical acumen.…”

“…The establishment of this study clinic was approved by the institutional review board of the hospital. The characteristics of the patients and their predictive factors of survival have been described in detail in previous publications 6,7 …”