Survival from severe paraquat intoxication in heavy drinkers

Ragoucy-Sengler, C.; Pileire, B.; Daijardin, J B

doi:10.1016/0140-6736(91)92762-q

Cited by 10 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven and four studies used plasma or urine paraquat concentrations, respectively, for prediction of prognosis; one study used arterial blood gas analysis, and four used fairly simple biochemical and/or haematological assays. One study reported that Caribbean men with a history of chronic alcohol use and raised γGT and MCV had a good prognosis but was unable to quantify it 35. A recent study reported an association between renal and liver failure and a metabolic acidosis with poor outcome but offered no method for distinguishing people who would survive from those who wouldn't 42.…”

Section: Resultsmentioning

confidence: 99%

Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review

Eddleston¹,

Wilks²,

Buckley³

2003

QJM: An International Journal of Medicine

106

View full text Add to dashboard Cite

The authors of the RCT have performed valuable and difficult research, but their results are hypothesis-forming rather than conclusive; elsewhere, the use of historical controls is problematic. In the absence of a validated prognostic marker, a large RCT of immunosuppression using death as the primary outcome is required. This RCT should also prospectively test and validate the available prognostic methods, so that future patients can be selected for this and other therapies on admission.

show abstract

Section: Resultsmentioning

confidence: 99%

Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review

Eddleston¹,

Wilks²,

Buckley³

2003

QJM: An International Journal of Medicine

106

View full text Add to dashboard Cite

show abstract

“…Postmortem serum amylase and isoenzyme assays were performed, and the total amylase concentration in the postmortem serum was 580 U/L and the pancreatic amylase concentration was 68 U/L. Michiue's study [30] showed that the cut‐off values for the postmortem left and right cardiac serum AMY to discriminating intoxication and other groups were 550 U/L and 450 U/L, respectively, and serum S‐type amylase levels showed a tendency to increase more significantly in the toxic group, consistent with the results of this case. Elevated serum amylase may be explained as follows: 1. mild pancreatic damage; 2. impaired renal clearance; 3. gastrointestinal damage.…”

Section: Discussionmentioning

confidence: 99%

Homicidal paraquat poisoning: Poisoned while drinking

Liu

Huang

Zhao

et al. 2022

Journal of Forensic Sciences

View full text Add to dashboard Cite

The incidence of paraquat poisoning has significantly decreased with the addition of odorizer and emetics to the liquid concentrate. Paraquat poisonings are usually attributed to suicidal and accidental or occupational exposure. Here, we report an unusual fatal case of homicidal paraquat poisoning. An intoxicated, a 37‐year‐old man consumed a mixture of white wine and paraquat prepared by his wife. This resulted in intermittent vomiting, which he attributed to being intoxicated. The man was admitted to the hospital for treatment 3 days later. Due to the lack of knowledge of paraquat exposure, the man did not receive effective treatment and died of respiratory failure 22 days later. High‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) was applied to detect paraquat in 16 postmortem specimens: kidney (1.31 ug/g), urine (0.91 ug/ml), liver (0.62 ug/g), lung (0.39 ug/g), muscle (0.35 ug/g), bile (0.32 ug/ml), heart (0.28 ug/g), brain (0.22 ug/g), pancreas (0.22 ug/g), spleen (0.18 ug/g), cardiac blood (0.15 ug/ml), cerebrospinal fluid (0.14 ug/ml), pericardial effusion (0.12 ug/ml), pleural effusion (0.09 ug/ml), peripheral blood (0.08 ug/ml), and vitreous humor (0.06 ug/ml). The highest concentration of paraquat was detected in the kidney followed by the urine in all tissues and body fluids. At present, although the cases of paraquat poisoning have decreased, the high mortality rate resulting from its irreversible lung damage and respiratory failure makes paraquat poisoning, especially occult paraquat poisoning, still needs to be carefully identified in forensic practice and clinical diagnosis.

show abstract

Paraquat

Lock¹,

Wilks²

2010

Hayes' Handbook of Pesticide Toxicology

View full text Add to dashboard Cite

Survival from severe paraquat intoxication in heavy drinkers

Cited by 10 publications

References 6 publications

Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review

Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review

Homicidal paraquat poisoning: Poisoned while drinking

Paraquat

Contact Info

Product

Resources

About