Survival Experience in The Breast Cancer Detection Demonstration Project

Seidman, Herbert; Gelb, Steven K.; Silverberg, Edwin; LaVerda, Nancy L.; Lubera, John A.

doi:10.3322/canjclin.37.5.258

Cited by 215 publications

(79 citation statements)

References 14 publications

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“…The relatively stable ASIR in Jamaica over the past decade, with an ASIR of 40.1 per 100 000 in the previous Jamaica Cancer Registry report (Gibson et al, 2008), is not in keeping with the increasing incidence of breast cancer in other countries, attributed to screening mammography (Richardson et al, 2005). In populations that receive regular screening mammography, the percentage of patients with locally advanced disease is less than 5% (Seidman et al, 1987). Approximately 30% of our patients had Stage III disease, reflecting the inadequacy of national programmes for early breast cancer detection.…”

Section: Discussionmentioning

confidence: 87%

Clinicopathologic Characteristics of Breast Cancer in Jamaica

Chin

Green²,

Strachan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (7), 3319-3322 IntroductionBreast cancer is the most common cancer diagnosed in Jamaican women, accounting for almost one-third of all cancers. The most recent publication of the Jamaica Cancer Registry reported a breast cancer age-standardized incidence rate (ASIR) of 43.1 per 100 000 (Gibson et al., 2010). The overall survival for breast cancer varies worldwide, with developing countries having a lower survival (57%) than developed countries (73%) (Parkin et al., 2005). Breast cancer survival worsens with more advanced stage at presentation; survival for Stage I tumours has been reported to be as high as 97-100%, while that of Stage III cancer ranges from 55 to 71% (Sant et al., 2004). In Jamaica, the survival for Stage I breast cancer has been reported to be as low as 67% (Walters, 1994).It has been our clinical experience that a significant proportion of women with breast cancer present with large primary tumours with extensive nodal involvement, without distant metastases (locally advanced disease). There is no published data on the stages of presentation of breast cancer in Jamaican women. In this retrospective study, we assessed the clinical and surgico-pathologic features of breast cancer in patients attending the Haematology/Oncology clinic at the University Hospital of the West Indies (UHWI), a tertiary care hospital in Kingston, Jamaica, during a 2-year period.

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Section: Discussionmentioning

confidence: 87%

Clinicopathologic Characteristics of Breast Cancer in Jamaica

Chin

Green²,

Strachan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Firstly, mammographic screening, which allows detection of earlier lesions, is under-utilized in our population. In populations that receive regular screening mammography, the percentage of patients with locally advanced disease is less than 5% (Seidman et al, 1987). Very few women in our review had mammographically detected tumors; in fact, most had tumours that were large enough to allow self-detection (median size 3.5cm).…”

Section: Discussionmentioning

confidence: 80%

Locally Advanced Breast Cancer in Jamaica: Prevalence, Disease Characteristics and Response to Preoperative Therapy

Chin

Green²,

Gordon‐Strachan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Breast cancer is the most common cancer in Jamaican women. Locally advanced breast cancer (LABC) is associated with aggressive biology and poor prognosis, and has a predilection for African-American women. In this retrospective review, we assessed the prevalence of LABC as a breast cancer presentation in a population of mainly Afro-centric ethnicity, and determined disease characteristics and response to pre-operative chemotherapy. LABC was prevalent (20%), and had a low pathological response rate to pre-operative chemotherapy, with a high risk of disease recurrence. Increased utilization of breast cancer screening may help detect cancer at less advanced stages, and optimizing pre-operative chemotherapy is recommended to improve response rates and ultimately survival. reviewed the prevalence and characteristics of LABC as a presentation amongst newly diagnosed breast cancer patients seen in the Haematology/Oncology clinic at the University Hospital of the West Indies (UHWI), a tertiary care hospital in Kingston, Jamaica. We also assessed the clinical and pathological tumour response to pre-operative chemotherapy, and patient outcomes during post-therapy surveillance. Materials and MethodsAfter approval from the UHWI/UWI/Faculty of Medical Sciences Ethics Committee, a list of all newpatient consultations booked for the Haematology/ Oncology Clinic for the 2-year period 2006 to 2007 was obtained from the Medical Records Department, UHWI. Retrievable medical charts were reviewed to identify patients with a diagnosis of breast cancer. We performed data extraction using a standardized extraction template to collect data for all breast cancer patients including: patient age, sex, parish of residence, reason for investigation for breast cancer (including palpable breast lump, abnormal mammogram, physician-detected abnormality) and any history of prior screening mammograms (mammograms performed as part of investigation of current diagnosis were excluded). Charts were reviewed for results of investigations to exclude metastases (including bone scan, Chest X-ray, Abdominal Ultrasound, CT scan chest/abdomen) and histopathology reports reviewed for tumour size and nodal status; TNM stage was then

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“…23 While reported results suggest an overall benefit associated with screening, 24,25 to our knowledge, there are no published reports that detail race-specific findings.…”

Section: Observational Datamentioning

confidence: 97%

Jones BA, Patterson EA, Calvocoressi L. Mammography screening in African American women: evaluating the research. Cancer. (2003) 97(1 Suppl):258–272.

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Cancer

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Survival Experience in The Breast Cancer Detection Demonstration Project

Cited by 215 publications

References 14 publications

Clinicopathologic Characteristics of Breast Cancer in Jamaica

Clinicopathologic Characteristics of Breast Cancer in Jamaica

Locally Advanced Breast Cancer in Jamaica: Prevalence, Disease Characteristics and Response to Preoperative Therapy

Jones BA, Patterson EA, Calvocoressi L. Mammography screening in African American women: evaluating the research. Cancer. (2003) 97(1 Suppl):258–272.

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