Survival difference among adult and pediatric mediastinal yolk sac tumors cases: A meta-analysis of case reports

Dabsha, Anas; Elkharbotly, Ismail A.M.H.; Yaghmour, Mohammad; Badr, Amr; Badie, Fady; Khairallah, Sherif; Esmail, Yomna M.; Hossny, Mohamed; Rizk, Amr; El-Demiry, Amr; Ghaly, Galal; Al-Thani, Shaikha; Demetres, Michelle; Mohamed, Abdelrahman; Villena-Vargas, Jonathan; Kamal, Mona; Rahouma, Mohamed

doi:10.1016/j.ejso.2024.108019

Cited by 2 publications

(3 citation statements)

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“…Notably, in many cases, authors choose a similar approach as in our case, with neo-adjuvant chemotherapy (most often BEP-regimen), followed by complete surgical resection [ 11 , 26 – 29 ]. More recently a meta-analysis was published on mediastinal yolk sac tumors revealing a poor prognosis with a median time to survival of 23 months for adult patients, 3-year overall survival of 24.4%, and 5-year overall survival of 23% [ 30 ]. On multivariate analysis the main predictors for favorable outcome were: undergoing surgery, receiving chemotherapy, and a more anterior localization of the tumor [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…More recently a meta-analysis was published on mediastinal yolk sac tumors revealing a poor prognosis with a median time to survival of 23 months for adult patients, 3-year overall survival of 24.4%, and 5-year overall survival of 23% [ 30 ]. On multivariate analysis the main predictors for favorable outcome were: undergoing surgery, receiving chemotherapy, and a more anterior localization of the tumor [ 30 ]. Furthermore, the authors claim that the most important cornerstones of the successful treatment of such malignancies are (1) early diagnosis (2) neoadjuvant chemotherapy and (3) surgical resection [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…On multivariate analysis the main predictors for favorable outcome were: undergoing surgery, receiving chemotherapy, and a more anterior localization of the tumor [ 30 ]. Furthermore, the authors claim that the most important cornerstones of the successful treatment of such malignancies are (1) early diagnosis (2) neoadjuvant chemotherapy and (3) surgical resection [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

Vandaele,

Van Slambrouck,

Schöffski

et al. 2024

World J Surg Onc

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Background Pleural neoplasms are rare and can be subdivided into pleural metastasis and primary pleural neoplasms. Non-mesothelioma primary pleural neoplasms are a diverse group of extremely rare pathologies. Case presentation In this case series, we describe the presentation and management of two rare primary pleural neoplasms. A first case describes a primary pleural yolk sac tumor treated with neoadjuvant chemotherapy, extended pleurectomy decortication, and hyperthermic intrathoracic chemotherapy. In a second case we describe the management of a primary pleural synovial sarcoma by neoadjuvant chemotherapy and extrapleural pneumonectomy. A complete resection was obtained in both cases and the post-operative course was uncomplicated. No signs of tumor recurrence were noted during follow-up in the first patient. In the second patient a local recurrence was diagnosed 6 months after surgery. Conclusion Neo-adjuvant chemotherapy followed by extensive thoracic surgery, including hyperthermic intrathoracic chemotherapy, is a feasible treatment strategy for non-mesothelioma primary pleural neoplasms, but careful follow-up is required.

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