Survival, Complications and Patient Reported Outcomes after Pancreatic Surgery

Baekelandt, Bart Maria Gilbert; Fagerland, Morten Wang; Hjermstad, Marianne Jensen; Heiberg, Turid; Labori, Knut Jørgen; Buanes, Trond

doi:10.1016/j.hpb.2018.07.023

Cited by 16 publications

(15 citation statements)

References 30 publications

(35 reference statements)

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“…In this study, severe PCs, defined as those of CD grade IIIa or higher, occurred in 13.1% of patients who underwent pancreatic surgery, with an overall morbidity rate of 46.4% including CD grade I or II. These incidence rates of PCs after pancreatic surgery were comparable to those of recent studies 21–25 . This study revealed that E‐PASS was superior to POSSUM in terms of the predictive power for the occurrence of PCs‐CD ≥ IIIa.…”

Section: Discussionsupporting

confidence: 87%

“…The development of PCs after pancreatic surgery can lead to serious consequences including prolonged hospital stays, the delay of subsequent treatments, and impaired prognosis. [21][22][23] A precise preoperative risk assessment enables surgeons to formulate appropriate management strategies for individual patients undergoing pancreatic surgery.…”

Section: Discussionmentioning

confidence: 99%

“…These incidence rates of PCs after pancreatic surgery were comparable to those of recent studies. [21][22][23][24][25] This study revealed that E-PASS was superior to POSSUM in terms of the predictive power for the occurrence of PCs-CD ≥ IIIa. This result was supported by the fact that the CRS of E-PASS was an independent predictor of PCs-CD ≥ IIIa in multivariate analysis and that PCs-CD ≥ IIIa can be predicted using the cutoff value of CRS set at 0.401.…”

Section: Discussionmentioning

confidence: 99%

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Accurate prediction of severe postoperative complications after pancreatic surgery: POSSUM vs E‐PASS

Hayashi

Yasunari

Nishi

et al. 2020

J Hepato Biliary Pancreat

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Despite recent advances in the perioperative management of surgical patients and operative techniques, there is still a high incidence of postoperative complications (PCs) such as postoperative pancreatic fistula (POPF) after pancreatic surgery which can lead to life-threatening complications including intra-abdominal infections, severe sepsis, and massive bleeding. The most commonly used assessment tools for the prediction of PCs after gastrointestinal surgery are the physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) and estimation of physiologic ability and surgical stress (E-PASS). 1,2 POSSUM was developed in the United Kingdom in 1991 for surgical audit. 1 This scoring system is widely known as the first prevalent tool to predict PCs and has been used in various surgical subspecialties worldwide. On the other hand, E-PASS was developed in Japan

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Accurate prediction of severe postoperative complications after pancreatic surgery: POSSUM vs E‐PASS

Hayashi

Yasunari

Nishi

et al. 2020

J Hepato Biliary Pancreat

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“…There are numerous explanations for the scarcity of data on health related quality of life (HQoL) in this group of patients. One important problem is that disease specific QoL measures are comprehensive, including irrelevant questions which result in low response rates from patients included in prospective trials[49]. This problem has recently been solved by development of the PC Disease Impact (PACADI) score[50].…”

Section: Discussionmentioning

confidence: 99%

Long term oncological outcome of laparoscopic techniques in pancreatic cancer

Buanes¹,

Edwin²

2018

WJGE

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The laparoscopic technique in distal pancreatic resection (LDP) has been widely accepted, and outcome data support the hypothesis that survival is improved, partly due to improved postoperative safety and recovery, thus optimizing treatment with adjuvant chemotherapy. But laparoscopic pancreaticoduodenectomy (LPD or Whipple-procedures) has spread more slowly, due to the complexity of the procedure. Surgical safety has been a problem in hospitals with low patient volume, resulting in raised postoperative mortality, requiring careful monitoring of outcome during the surgical learning curve. Robotic assistance is expected to improve surgical safety, but data on long term oncological outcome of laparoscopic Whipple procedures with or without robotic assistance is scarce. Future research should still focus surgical safety, but most importantly long term outcome, recorded as recurrence at maximal follow up or - at best - overall long term survival (OS). Available data show median survival above 2.5 years, five year OS more than 30% after LDP even in series with suboptimal adjuvant chemotherapy. Also after LPD, long term survival is reported equal to or longer than open resection. However, surgical safety during the learning curve of LPD is a problem, which hopefully can be facilitated by robotic assistance. Patient reported outcome should also be an endpoint in future trials, including patients with pancreatic ductal adenocarcinoma.

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“…These post-operative complications were correlated with reduced survival in patients with malignant disease. Studies have also focused on post-operative psychological changes in pancreatic cancer patients (32). Among studies on Pakistani pancreatic cancer patients, complaints on disease presentation at hospital were reported by 8 researches while postoperation complications were investigated by only 5 studies.…”

Section: Complains/ Complications On Presentation Of Disease and Post-operationmentioning

confidence: 99%

Pancreatic Cancers: A Review of Studies from Pakistan and Comparison with Global Trends

Adnan

Ali

2021

PJPH

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The objective of this review article is to discuss clinical data from studies on Pakistani pancreatic cancer population and its comparison with international data. This review article will allow researchers to identify gaps in the data and hence to design further research in order to address these gaps accordingly. Search was carried out via Google Scholar, PubMed and PakMediNet search engines using keywords “Pancreatic cancers”, “Pancreatic adenocarcinoma” and “Pakistan”. Pancreatic cancers are one of the most lethal cancers globally. Statistics show that 97.8% of cases of pancreatic cancers in Pakistan have led to mortality. For various cancers around the world, epidemiological data has been used for development of diagnostic tools and therapies. Despite the alarming situation of pancreatic cancers in Pakistan, only limited work has been done in this area. Majority of the studies are based exclusively on reporting of clinical data. Pakistan has not been able to even gather sufficient data to proceed research based on association of molecular aspects of tumor with clinical characteristics. On the contrary, researchers, scientists and clinicians from other parts of the world are already working on association studies, prediction of prognosis, treatment selection and improving the survival of their population. It is an immense need of the situation that molecular based studies are carried out on Pakistani pancreatic cancer population so that diagnosis, prognosis, treatment and survival of these patients can be made better.

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Survival, Complications and Patient Reported Outcomes after Pancreatic Surgery

Abstract: Postoperative complications led to increased anxiety at 3 months after surgery and were associated with reduced long-term survival in patients with malignancy. A short, patient derived, disease specific questionnaire is required in the clinical research context.

Cited by 16 publications

References 30 publications

Accurate prediction of severe postoperative complications after pancreatic surgery: POSSUM vs E‐PASS

Accurate prediction of severe postoperative complications after pancreatic surgery: POSSUM vs E‐PASS

Long term oncological outcome of laparoscopic techniques in pancreatic cancer

Pancreatic Cancers: A Review of Studies from Pakistan and Comparison with Global Trends

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