Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis

An, Na; Leng, Xuejiao; Wang, Xue; Sun, Yile; Chen, Zhiwei

doi:10.1016/j.lungcan.2020.01.020

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…LUSC can be divided into basaloid squamous cell carcinoma (BSCC), keratinized squamous cell carcinoma (KSCC), and nonkeratinized squamous cell carcinoma (NKSCC), and it is one of the most common histological subtypes of lung cancers [ 16 ]. In the past decades, scholars have been exploring the biological function of miRNAs.…”

Section: Discussionmentioning

confidence: 99%

miR-223-5p Suppresses OTX1 to Mediate Malignant Progression of Lung Squamous Cell Carcinoma Cells

2021

Computational and Mathematical Methods in Medicine

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Background. Lung squamous cell carcinoma (LUSC) features high morbidity and mortality as a worldwide malignant tumor. This study mainly explored a miR-223-5p-dependent mechanism that affected proliferation, invasion, and migration of LUSC cells. Methods. Expression data of mature miRNAs and sequencing data of total RNA of LUSC were downloaded from TCGA database. Differentially expressed mRNAs were obtained. Function of miR-223-5p in LUSC cells was detected by assays like qRT-PCR, MTT, wound healing assay, Western blot, and Transwell assay. Western blot was performed to analyze the relationship between OTX1 and JAK/STAT signaling pathways. Dual-luciferase assay detected the relationship between miR-223-5p and OTX1. The way how miR-223-5p regulated LUSC cell biological functions via OTX1 was further explored. Results. It was noted that miR-223-5p expression in LUSC tissue and cells was significantly reduced. Overexpression of miR-223-5p negatively regulated the proliferation, invasion, and migration of LUSC cells. The downstream target gene OTX1 was detected to be notably elevated in LUSC cells. A negative correlation between OTX1 and miR-223-5p was also found. As analyzed by GSEA, OTX1 was significantly enriched in the JAK/STAT signaling pathway and activated the pathway. Dual-luciferase assay demonstrated that OTX1 was a direct molecular target of miR-223-5p in LUSC cells. Rescue experiment verified that miR-223-5p regulated the malignant phenotypes of LUSC cells by pairing with OTX1. Conclusion. This study indicated that miR-223-5p was lowly expressed in LUSC cells. The impact of miR-223-5p on cell proliferation, invasion, and migration was realized by targeting OTX1. It is likely that miR-223-5p can be a novel target for LUSC treatment, which provides new ideas for future LUSC treatment.

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Section: Discussionmentioning

confidence: 99%

miR-223-5p Suppresses OTX1 to Mediate Malignant Progression of Lung Squamous Cell Carcinoma Cells

2021

Computational and Mathematical Methods in Medicine

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“…Previous studies had confirmed that some clinical characteristics, such as age, histological type, tumor size, tumor stage, and treatment, played a pivotal role in the prognosis of patients with LUSC and constructed predictive models. 11,12 With the popularization of genomics, researchers paid more attention to the impact of differences at the molecular level on patients' prognosis with LUSC. They identified many molecular markers that were believed to be at the core of most cases of LUSC, involving protein, mRNA, lncRNA, circRNA, miRNA, and DNA methylation, etc.…”

Section: Discussionmentioning

confidence: 99%

Identification of a glycolysis‐related gene signature associated with clinical outcome for patients with lung squamous cell carcinoma

Zhang

Nian

et al. 2021

Cancer Medicine

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Lung cancer has an exceptionally high incidence and mortality among all tumors worldwide. It is predicted that there would be 228,820 cases newly diagnosed with lung cancer, and 135,720 cases would die from this tumor in 2020, causing a tremendous social burden. 1 Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma constitute the central part of lung cancer and the former accounts for approximately 25%-30% of all lung. In recent years, the survival of patients with advanced lung adenocarcinoma has been dramatically improved due to

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“…A study reported patients with gains of 11q13.1 had a poor survival ( 34 ). However, a recent propensity score matching (PSM) analysis reported that patients with BSCC had a better prognosis than those with KSCC or NKSCC ( 35 ). Further analysis of long-term survival time based on larger cohorts is in urgent need to determine whether prognosis of BSCC truly differs from the other two subtypes.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Molecular Characterizations of Chinese Patients With Different Subtypes of Lung Squamous Cell Carcinoma

et al. 2020

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BackgroundThis study aims to profile integrative genomic spectra of Chinese patients with different subtypes of lung squamous cell carcinoma (LUSC) and explore potential molecular prognosis factors.MethodsWe retrospectively identified 204 surgically resected LUSC patients in Shanghai Chest Hospital who underwent capture-based targeted next-generation sequencing (NGS) with a panel of 68 lung cancer‐related genes from September 2017 to January 2019. NGS was used to profile comprehensive molecular characterizations.ResultsOf 204 cases, 114 (55.9%) were keratinizing squamous cell carcinoma (KSCC), 77 (37.7%) were non-keratinizing squamous cell carcinoma (NKSCC), 13 (6.4%) were basaloid squamous cell carcinoma (BSCC), respectively. All subtypes presented similarly high proportions of mutations, including TP53, CDKN2A, and NOTCH1. A comparable prevalence of FGFR1 amplifications was identified between KSCC and NKSCC (11.4 versus 26.9%, p = 0.007). Compared with NKSCC, IGF1R amplifications were more frequent in BSCC (0 versus 15.4%, p = 0.019). We found cases with TP53 alterations had less EGFR alterations in KSCC (P = 0.013, OR = 0.158). Compared with TCGA cohorts, our Chinese cohorts exhibited statistic differences in both somatic mutations and signaling pathways. We found that STK 11 alterations and TOP2A alterations were significantly associated with higher risk of recurrence in patients with LUSC.ConclusionsSignificant differences exist among three subtypes of LUSC in molecular characterizations.

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Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis

Cited by 16 publications

References 24 publications

miR-223-5p Suppresses OTX1 to Mediate Malignant Progression of Lung Squamous Cell Carcinoma Cells

miR-223-5p Suppresses OTX1 to Mediate Malignant Progression of Lung Squamous Cell Carcinoma Cells

Identification of a glycolysis‐related gene signature associated with clinical outcome for patients with lung squamous cell carcinoma

Comprehensive Molecular Characterizations of Chinese Patients With Different Subtypes of Lung Squamous Cell Carcinoma

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