Survival Benefit of Lymphadenectomy for Endometrioid Carcinoma of Ovary: A SEER-based Study

Abstract

Background. The potential therapeutic benefits of lymphadenectomy for patients with ovarian endometrioid carcinoma (EOC) remain vague. Therefore, a retrospective population-based analysis was performed to determine the relationship between lymphadenectomy and the survival rate of female patients with EOC. Materials and Methods. The surveillance, epidemiology and final results (SEER) program database was retrospectively analyzed and data were collected on 6106 female patients with EOC from 2004 to 2015. Main patient and tumor characteristics include marital status, age, ethnicity, time of diagnosis, stage, stage, grade, tumor size, radiotherapy, treatment, chemotherapy, and lymphadenectomy status. Using the IT-AIC method to estimate the effects of lymphadenectomy in a multivariate environment, Kaplan-Meier and Cox proportional risk regression analysis was performed to determine the relationship between lymphadenectomy and EOC overall survival (OS) and cancer-specific survival (CSS). Results. A total of 3587 and 1332 women with stage I and III-IV EOC who met the inclusion criteria were identified. Lymphadenectomy 2738 (76.3%) and 786 (59.0%) (P < 0.001). With multivariate analysis, lymphadenectomy as a classification and continuous variable is an independent prognostic factor, and patients with lymphadenectomy have a better prognosis. And the results showed that age, marital status, TNM staging, grading, surgery, chemotherapy and lymphadenectomy had a significant correlation with the CSS of EOC, and the age < 50 years, chemotherapy, early staging and early grading, and women with EOC who did not undergo debulking surgery and married had a better prognosis. Conclusions. Lymphadenectomy can improve long-term OS and cancer-specific survival (CSS) of EOC.