Survival Benefit of and Indications for Adjuvant Chemotherapy for Resected Colorectal Liver Metastases—a Japanese Nationwide Survey

Kobayashi, Shin; Beppu, Teruhiko; Honda, Goro; Yamamoto, Masakazu; Takahashi, Keiichi; Endo, Itaru; Hasegawa, Kiyoshi; Kotake, Kenjiro; Itabashi, Michio; Hashiguchi, Yojiro; Kotera, Yoshihito; Sakamoto, Katsunori; Yamaguchi, Tatsuro; Morita, Satoshi; Tabuchi, Ken; Miyazaki, Masaru; Sugihara, Kenichi

doi:10.1007/s11605-019-04250-9

Cited by 18 publications

(22 citation statements)

References 29 publications

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“…We performed a meta-analysis of 5-year survival rate in the three above-mentioned, randomized, phase III trials 20,21 regarding the 5-year survival rate ( Figure 9A). Consistent with a recent retrospective study adopting PSM 187 , the results suggested that administering chemotherapy after hepatectomy increased the 5-year survival rate by 10% (95% CI: 9%-28%, P = .32) compared with hepatectomy alone. The relative risk of overall survival was 0.80 (95% CI: 0.56-1.16, P = .24).…”

Section: F I G U R Esupporting

confidence: 87%

Clinical practice guidelines for the management of liver metastases from extrahepatic primary cancers 2021

Yamamoto

Yoshida

Furuse

et al. 2020

J Hepato Biliary Pancreat

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Background Hepatectomy is standard treatment for colorectal liver metastases; however, it is unclear whether liver metastases from other primary cancers should be resected or not. The Japanese Society of Hepato‐Biliary‐Pancreatic Surgery therefore created clinical practice guidelines for the management of metastatic liver tumors. Methods Eight primary diseases were selected based on the number of hepatectomies performed for each malignancy per year. Clinical questions were structured in the population, intervention, comparison, and outcomes (PICO) format. Systematic reviews were performed, and the strength of recommendations and the level of quality of evidence for each clinical question were discussed and determined. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess evidence and make recommendations. Results The eight primary sites were grouped into five categories based on suggested indications for hepatectomy and consensus of the guidelines committee. Fourteen clinical questions were devised, covering five topics: (1) diagnosis, (2) operative treatment, (3) ablation therapy, (4) the eight primary diseases, and (5) systemic therapies. The grade of recommendation was strong for one clinical question and weak for the other 13 clinical questions. The quality of the evidence was moderate for two questions, low for 10, and very low for two. A flowchart was made to summarize the outcomes of the guidelines for the indications of hepatectomy and systemic therapy. Conclusions These guidelines were developed to provide useful information based on evidence in the published literature for the clinical management of liver metastases, and they could be helpful for conducting future clinical trials to provide higher‐quality evidence.

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Section: F I G U R Esupporting

confidence: 87%

Clinical practice guidelines for the management of liver metastases from extrahepatic primary cancers 2021

Yamamoto

Yoshida

Furuse

et al. 2020

J Hepato Biliary Pancreat

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“…The appropriate cut-off values for CA19-9 and operative time were determined based on previously reported studies. 12,14 To investigate the survival benefit from liver resection for CRLM patients with extrahepatic metastases, a 1:1 nearest neighbor propensity score matching (PSM) analysis was performed. The analysis was based on age, sex, tumor markers, primary location, primary T and N Stage, primary tumor differentiation, and liver metastasis behaviors.…”

Section: Resultsmentioning

confidence: 99%

“…Data of 3820 patients who were newly diagnosed with CRLM between 2005 and 2007 were retrospectively registered. 11,12 In this study, we analyzed data from this cohort and further conducted a sub-analysis focusing on the outcomes of liver resection for CRLM in the presence of extrahepatic disease. The database provided a comprehensive dataset, which encompassed baseline characteristics, preoperative assessment, surgical treatment, histopathology, and the postoperative course of all included patients.…”

Section: Methodsmentioning

confidence: 99%

“…Characteristics of the 3820 CRLM patients included in the Japanese survey have been described in previous reports. 11,12 One thousand eighty-five of these patients were simultaneously diagnosed with CRLM and extrahepatic metastasis. Of this sub-group, 251 were treated with liver resection between 2005 and 2011; 834 were treated without liver resection ( Figure 1).…”

Section: Patient Demographicsmentioning

confidence: 99%

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Long‐term outcome of liver resection for colorectal metastases in the presence of extrahepatic disease: A multi‐institutional Japanese study

Sawada

Sahara

Endo

et al. 2020

J Hepato Biliary Pancreat

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Background/Purpose: The purpose of the present study was to assess long-term outcomes following liver resection for colorectal liver metastases (CRLM) with concurrent extrahepatic disease and to identify the preoperative prognostic factors for selection of operative candidates. Methods: In this retrospective, multi-institutional study, 3820 patients diagnosed with CRLM during 2005-2007 were identified using nationwide survey data. Data of identified patients with concurrent extrahepatic lesions were analyzed to estimate | 811 SAWADA et Al.

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“…Postoperative chemotherapy has been shown to be effective for improving disease-free and overall survival of patients with CRLM who underwent liver resection (16). Chemotherapy has been recommended to start within 2 months after resection of stage III colon cancer.…”

mentioning

confidence: 99%

Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?

Akahoshi¹,

Beppu²,

Mori³

et al. 2020

Hepatobiliary Surg Nutr

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Survival Benefit of and Indications for Adjuvant Chemotherapy for Resected Colorectal Liver Metastases—a Japanese Nationwide Survey

Cited by 18 publications

References 29 publications

Clinical practice guidelines for the management of liver metastases from extrahepatic primary cancers 2021

Clinical practice guidelines for the management of liver metastases from extrahepatic primary cancers 2021

Long‐term outcome of liver resection for colorectal metastases in the presence of extrahepatic disease: A multi‐institutional Japanese study

Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?

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