Survival associated with extent of radical hysterectomy in early-stage cervical cancer: a subanalysis of the Surveillance in Cervical CANcer (SCCAN) collaborative study

Bizzarri, Nicolò; Querleu, Denis; Dostálek, Lukáš; Lonkhuijzen, Luc van; Giannarelli, Diana; López, Aldo; Salehi, Sahar; Ayhan, Ali; Kim, Sarah H.; Ortiz, David Isla; Klát, Jaroslav; Landoni, Fabio; Pareja, René; Manchanda, Ranjit; Kosťun, Ján; Ramírez, Pedro T.; Meydanlı, Mehmet Mutlu; Odetto, Diego; Laky, R; Zapardiel, Ignacio; Weinberger, Vít; Reis, Ricardo dos; Anchora, Luigi Pedone; Amaro, Karina; Akıllı, Hüseyin; Abu‐Rustum, Nadeem R.; Salcedo‐Hernández, Rosa A.; Javurková, Veronika; Mom, Constantijne H.; Scambia, Giovanni; Falconer, Henrik; Cibula, David

doi:10.1016/j.ajog.2023.06.030

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…However, even if this will be the case in the future, the need to determine the extent of radical surgery still remains, as this is directly related to perioperative and long-term postoperative complications. A recent multi-institutional study tailored the survival benefit of the extent of the procedure in patients with FIGO 2009 stages Ib1 and IIa1 [ 11 ]. The study involved 1257 patients that were offered radical hysterectomy by laparotomy, and it was observed that the extent of radicality of the procedure had a significant impact on disease-free survival (DFS) of patients with tumors with a diameter that ranged between 2 and 4 cm (current FIGO staging Ib2) (83.1% for nerve-sparing cases vs. 90.3% for non-nerve-sparing cases; p = 0.016).…”

Section: Early-stage Disease Challengesmentioning

confidence: 99%

Controversies and Advances in the Personalized Surgical Treatment of Cervical Cancer

Pergialiotis,

Rodolakis,

Rodolakis

et al. 2024

JPM

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Cervical cancer represents a global health issue as it is mostly encountered in women of reproductive age, while at the same time, survival outcomes seem to have remained constant during the last two decades. The need to implement fertility-sparing strategies as well as to decrease the morbidity that accompanies radical treatment has been extensively studied. During the last decade, several randomized clinical trials have been released, resulting in significant advances in the surgical treatment of early-stage disease. At the same time, evidence about the surgical treatment of advanced-stage disease as well as recurrent disease has gradually appeared and seems to be promising, thus leading the point forward towards personalized medicine that will remove the surgical barriers that seem concrete in our era. Nevertheless, the discrepancies in perioperative morbidity and survival outcomes that were observed among published studies raise several questions. In the present article, we chose to review the gray fields in the surgical treatment of early-stage and advanced-stage cervical cancer. Studies that are based on strong evidence that support current clinical practice are compared to smaller cohorts that present novel data that may form the basis for future research, and issues that remain poorly explored are discussed in an effort to help establish a consensus for future research development.

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Section: Early-stage Disease Challengesmentioning

confidence: 99%