Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis

Green, John A.; Kirwan, John; Tierney, Jayne; Symonds, Paul; Fresco, L.; Collingwood, M; Williams, Christopher J.

doi:10.1016/s0140-6736(01)05965-7

Cited by 985 publications

(423 citation statements)

References 18 publications

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“…These IR-specific signatures would be used for an important discriminator of stress-response against other types of DNA damage. In addition, our data demonstrates that the mechanisms of cellular responses to chemotherapeutic drugs and radiotherapy are independent, which might support well-known synergistic effects of the combined chemo-and radiotherapy in advanced malignancies (Green et al, 2001).…”

Section: Discussionsupporting

confidence: 79%

Identification of radiation-specific responses from gene expression profile

et al. 2002

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Section: Discussionsupporting

confidence: 79%

Identification of radiation-specific responses from gene expression profile

et al. 2002

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“…In fact, our data in this regard are comparable with those of much larger series where patients were treated with chemo-radiotherapy as analyzed recently by Green, et al [21][22]. By way of example, for early-stage and locally advanced disease, the five-year rates of central pelvic disease control were 94% and 87%, respectively, in the analysis by Katz and Eifel [13].…”

Section: Discussionsupporting

confidence: 88%

A Novel Applicator for Intracavitary Low-Dose-Rate Brachytherapy (LDR) for Carcinoma of the Uterine Cervix: Results of a Single Institutional Trial

Elsayyad¹,

Takita²,

Walker³

et al. 2010

Cureus

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“…A recent meta-analysis of treatments with concurrent chemo- and radiotherapy showed a greater beneficial effect with improvements in PFS and OS in studies that included a high proportion of stage I/II patients. However, caution was advised in extrapolating the results to patients with advanced disease stage [11]. …”

Section: Discussionmentioning

confidence: 99%

A Phase II Trial with Cisplatin-Paclitaxel Cytotoxic Treatment and Concurrent External and Endocavitary Radiation Therapy in Locally Advanced or Recurrent Cervical Cancer

Miglietta¹,

Franzone²,

Centurioni³

et al. 2006

Oncology

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Background: Five randomized studies have demonstrated a beneficial effect of adding cisplatin-based chemotherapy to radiation therapy in the treatment of cervical carcinoma. In the present phase II study, we evaluated the response and toxicity of ciplatin-Taxol chemotherapy combined with concomitant radiotherapy in patients with locally advanced cervical carcinoma (LACC) and locally recurrent cervical carcinoma (LRCC). Patients and Methods: In 2000, this phase II study was initiated with a chemotherapy regimen of cisplatin (75 mg/m²) and Taxol (175 mg/m²) every 21 days, for four cycles, concomitant with external radiotherapy and high-dose-rate brachytherapy. Pelvic radiotherapy was started 2 weeks after the first chemotherapy cycle, while the first brachytherapy insertion was carried out during the fourth chemotherapy cycle. SCC marker was determined before treatment and after every chemotherapy cycle. Results: All of the 27 patients treated achieved a complete clinical response. Two patients with LACC experienced distant recurrence 22 and 24 months after complete response, respectively, and 1 patient with LRCC had local progression 6 months after the end of radiotherapy. Although generally tolerable, neutropenia grade 3–4 in 4 patients and anemia grade 3 in 2 patients were observed, and 1 patient experienced grade 2 neurotoxicity; toxicity due to radiotherapy was moderate. Conclusions: Concomitant cisplatin-Taxol chemoradiotherapy seems to be well tolerated, and results, even in this small series, are encouraging.

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Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis

Cited by 985 publications

References 18 publications

Identification of radiation-specific responses from gene expression profile

Identification of radiation-specific responses from gene expression profile

A Novel Applicator for Intracavitary Low-Dose-Rate Brachytherapy (LDR) for Carcinoma of the Uterine Cervix: Results of a Single Institutional Trial

A Phase II Trial with Cisplatin-Paclitaxel Cytotoxic Treatment and Concurrent External and Endocavitary Radiation Therapy in Locally Advanced or Recurrent Cervical Cancer

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