Survival and quality of life in rheumatoid arthritis–associated interstitial lung disease after lung transplantation

Yazdani, Ahmad; Singer, Lianne G.; Strand, Vibeke; Gelber, Allan C.; Williams, Lawrence J.; Mittoo, Shikha

doi:10.1016/j.healun.2014.01.858

Cited by 66 publications

(38 citation statements)

References 26 publications

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“…Our data are consistent with the one prior publication reporting HRQL in RA-ILD 14 . In this study, the authors report SF-36 scores from seven RA-ILD patients obtained a median 94 days prior to lung transplant (inter-quartile range of 59 days): mean PCS 22.4 ± 8.1 and mean MCS 44.7 ± 15.3.…”

Section: Discussionsupporting

confidence: 93%

Understanding the determinants of health-related quality of life in rheumatoid arthritis-associated interstitial lung disease

Natalini

Swigris

Morisset

et al. 2017

Respiratory Medicine

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Rationale Health-related quality of life (HRQL) is impaired among patients with interstitial lung disease (ILD). Little is understood about HRQL in specific subtypes of ILD. Objectives The aim of this study was to characterize and identify clinical determinants of HRQL among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and compare them to patients with idiopathic pulmonary fibrosis (IPF). Methods We identified patients with a diagnosis of RA-ILD and IPF from an ongoing longitudinal cohort of ILD patients. HRQL was measured at their baseline visit using the Short Form Health Survey (SF-36), versions 1 and 2. Regression models were used to characterize and understand the relationship between selected baseline clinical covariates, the physical component score (PCS) and mental component score (MCS) of the SF-36. Measurements and Main Results RA-ILD patients (n=50) were more likely to be younger and female compared to IPF patients (n=50). After controlling for age and pulmonary function, RA-ILD patients had a lower HRQL compared to IPF patients, as measured by the PCS (P=0.03), with significant differences in two of four PCS domains – bodily pain (P<0.01) and general health (P=0.01). Clinical covariates most strongly associated with a lower PCS in RA-ILD patients compared to IPF patients were the presence of joint pain or stiffness and dyspnea severity (P<0.01). Mental and emotional health, as measured by the MCS, was similar between RA-ILD and IPF patients. Conclusion The physical components of HRQL appear worse in RA-ILD patients compared to IPF patients as measured by the PCS of the SF-36. Differences in the PCS of the SF-36 can be explained in part by dyspnea severity and joint symptoms among patients with RA-ILD.

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Section: Discussionsupporting

confidence: 93%

Understanding the determinants of health-related quality of life in rheumatoid arthritis-associated interstitial lung disease

Natalini

Swigris

Morisset

et al. 2017

Respiratory Medicine

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show abstract

“…In patients with a UIP pattern, work-up for transplant should be considered early. A retrospective review of Canadian patients with advanced lung disease found no difference in outcomes between patients with RA-ILD and those with IPF at 1 year following lung transplant, suggesting that transplant is a reasonable option for these patients [47].…”

Section: Managementmentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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“…Survival rates after transplant for RA-ILD are similar to those for IPF and with significant improvements in quality-of-life scores following transplantation. 45 …”

Section: Forms Of Lung Disease In Rheumatoid Arthritismentioning

confidence: 99%