Survival and progression to AIDS in a seroconverter cohort in the post-highly active antiretroviral therapy era: effectiveness goes on

Pérez-Hoyos, Santiago; Ferreros, Inmaculada; Amo, Julia del; Muga, Roberto; Romero, Jorge del; Olalla, Patricia García de; Hernández-Aguado, Ildefonso

doi:10.1097/01.aids.0000202651.41397.db

Cited by 21 publications

(16 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, these results might be influenced by the fact that the study population includes a large proportion of MSM who are more likely to be closely monitored by HIV specialists and may therefore not be representative of the entire German population infected by HIV. A similar cohort study in Spain reported significant reduction in the risk of AIDS over calendar periods in comparison with the pre-HAART era, but there were no differences between the calendar periods in the post-HAART era [8]. However, the last observed calendar period was 20002003 and there were more IDU in the composition of this cohort than in our study.…”

Section: Discussioncontrasting

confidence: 58%

“…Just after the introduction of HAART in 1996, such studies showed a protective effect of HAART on time to acquired immunodeficiency syndrome (AIDS) [3-5]. Thereafter, continuous decrease on time to AIDS has been reported, coincident with the widespread uptake of HAART [6-8]. However, with ageing of the HIV-infected population, long-term exposure to treatment, varying adherence, emerging resistance and complications to therapies, there is a need to monitor regularly the effectiveness of HAART at the population level.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The risk of AIDS-defining events is decreasing over time in the German HIV-1 Seroconverter Cohort

Altmann

Heiden

Scheufele³

et al. 2012

BMC Infect Dis

View full text Add to dashboard Cite

BackgroundWith ageing of the HIV-infected population, long-term exposure to treatment, varying adherence, emerging resistance and complications to therapies, effectiveness of Highly Active Antiretroviral Therapy (HAART) needs to be monitored continuously at the population level. The German HIV-1 Seroconverter Cohort is a multi-centre, open, long-term observational cohort including patients with a known or reliably estimated date of HIV-infection i.e. last negative and first positive HIV antibody test within a maximum three-year interval or laboratory evidence of seroconversion. Our study aims to investigate survival improvements and changes in AIDS risk over calendar periods in the German HIV-1 Seroconverter Cohort.MethodsRetrospective (for the pre-1997 period) and prospective (since 1997) data from the German HIV-1 Seroconverter Cohort were used. Time from seroconversion to first AIDS-defining event over calendar periods was analysed by using Cox models adjusting for age at seroconversion, sex, transmission groups and short HIV test interval. Kaplan-Meier methods were used to determine expected survival (remaining AIDS-free) by calendar period.Results2162 seroconverters with 8976 person-years of observation were included in our analysis (up to 31.12.2010). A total of 196 first AIDSdefining events were reported. Two periods i.e. 19972000 and 2007-2010 were statistically associated with a reduction in the risk of AIDS, accounting for an overall reduction of 80%. Compared to1997-2000, hazard ratios were 2.6 (95%CI, 1.6-4.8; p=0.000) in pre-1997 and 0.5 (95%CI, 0.3-0.8; p=0.007) in 20072010. Independent risk factor for AIDS progression was age at seroconversion (HR, 1.3 per 10year-increase; p=0.001).ConclusionHAART effectiveness has improved in the German HIV-1-Seroconverter Cohort. The risk to develop AIDS decreased significantly in 19972000 and in 20072010. However, elderly may require particular monitoring in view of their faster progression to AIDS.

show abstract

Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

The risk of AIDS-defining events is decreasing over time in the German HIV-1 Seroconverter Cohort

Altmann

Heiden

Scheufele³

et al. 2012

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…These factors cross all transmission routes and may confound or modify their effect on HIV. Highly active antiretroviral therapy (HAART) has led to a radical change in HIV prognosis,4 but there is a risk that the most vulnerable populations may be the least likely to benefit from available resources, contributing doubly to increased health inequalities.…”

Section: Introductionmentioning

confidence: 99%

Educational level and HIV disease progression before and after the introduction of HAART: a cohort study in 989 HIV seroconverters in Spain

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Such treatment has led to a drastic reduction in mortality associated to the acquired immunodeficiency syndrome (AIDS), and to increased survival among HIV-infected individuals HIV (1). In the year 2009, the HAART response rate was very high, affording sufficient host immune recovery to allow the control of opportunistic infections, thanks to the introduction of increasingly well tolerated and simpler treatments such as the combination of several drug substances in a single tablet (2).…”

Section: The Late Diagnosis Of Hiv Infection In Spain; Magnitude Rismentioning

confidence: 99%

Role of the dental surgeon in the early detection of adults with underlying HIV infection / AIDS

Campo¹,

Cano²,

J³

et al. 2012

Med Oral

View full text Add to dashboard Cite

A review is made of the late diagnosis of human immunodeficiency virus (HIV) infection, a subject of growing interest in public health. It has been estimated that in Europe 30% of all HIV-infected people are unaware of their seropositive condition, and this in turn is associated with a poorer long-term disease prognosis and an increased risk of transmission to other individuals. The role of the dental surgeon in this context could be of great importance, since there are many oral lesions that can suggest the existence of underlying infection. The study also addresses the controversial subject of rapid HIV testing, and whether these tests should be performed on a routine basis in the dental clinic, or whether it is preferable to refer the patient to a specialized center. Key words:HIV in Spain, HIV screening, early diagnosis.

show abstract

Survival and progression to AIDS in a seroconverter cohort in the post-highly active antiretroviral therapy era: effectiveness goes on

Cited by 21 publications

References 5 publications

The risk of AIDS-defining events is decreasing over time in the German HIV-1 Seroconverter Cohort

The risk of AIDS-defining events is decreasing over time in the German HIV-1 Seroconverter Cohort

Educational level and HIV disease progression before and after the introduction of HAART: a cohort study in 989 HIV seroconverters in Spain

Role of the dental surgeon in the early detection of adults with underlying HIV infection / AIDS

Contact Info

Product

Resources

About