Survival and prognostic factors in chronic lymphocytic leukemia

Pines, Amos; Ben‐Bassat, Isaac; Modan, Michaela; Blumstein, Tzvia; Ramot, Bracha

doi:10.1111/j.1600-0609.1987.tb01149.x

Cited by 15 publications

(1 citation statement)

References 22 publications

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“…As noted by Kern et al. (2014), p. 501, people seem to “function best in both personal and work lives when they have a sense of meaning or purpose, defined in terms of having a direction, connecting to something larger than oneself, and feeling that what one does is valuable.” Empirical findings support these ideas, indicating associations of a sense of meaning at work with desirable personal outcomes such as well-being (Arnold et al., 2007) and fulfillment (Steger et al., 2012), and with desirable outcomes at work, such as increased career and organizational commitment, organizational citizenship behavior, job satisfaction, intrinsic work motivation, retention, and performance, and fewer manifestations of burnout, absence days and withdrawal behavior (Clausen and Borg, 2011; Pines, 2011; Steger et al., 2012; Littman-Ovadia et al., 2017).…”

Section: Introductionmentioning

confidence: 90%

Teachers’ Sense of Meaning Associations With Teacher Performance and Graduates’ Resilience: A Study of Schools Serving Students of Low Socio-Economic Status

Lavy

Ayuob

2019

Front. Psychol.

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Adolescents from lower socio-economic status (SES) often experience distress in their personal life as well as at school. Moreover, their ability to overcome such difficulties and pave their path to a higher SES depends, to a certain extent, on their ability to develop resilience despite their disadvantaged background. Acknowledging the critical contribution of teachers to students’ development, in the present study, we focused on teachers as agents who may influence graduates’ resilience, and on their sense of meaning at work–a resource these teachers may draw upon to increase their performance and contribute to their disadvantaged students and to their relationships with them. Specifically, we postulated that teachers’ sense of meaning at work will be associated with teachers’ performance and that teachers’ relationships with their students would mediate this association, as they serve as the main vehicle through which teachers impact their students. We further suggested that teachers’ sense of meaning would have long-term effects on students’ coping abilities, reflected in school graduates’ resilience levels. The study comprised 857 participants, teachers and graduates, from 30 Arab vocational schools in Israel, comprising mainly low SES students. Teachers ( N = 436) completed self-report measures of their sense of meaning at work, relationships with students, and performance. Furthermore, to reveal potential long-term effects of teachers’ sense of meaning at work, school graduates ( N = 421) completed measures of their relationships with teachers and resilience. Analyses indicated a significant association of teachers’ sense of meaning with their performance, which was mediated by teachers’ reports of their relationships with students. Furthermore, teachers’ sense of meaning at work and graduates’ perceptions of their relationships with the teachers were both significantly associated with graduates’ resilience. The findings highlight teachers’ sense of meaning at work as a potential contributor to their performance, which may also contribute to students’ resilience in lower SES schools. They point to teachers’ sense of meaning as a potential resource for teachers of lower SES students and highlight the importance of nurturing and developing it in various programs and practices (e.g., teacher training, teacher development, organizational routines).

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Section: Introductionmentioning

confidence: 90%

Teachers’ Sense of Meaning Associations With Teacher Performance and Graduates’ Resilience: A Study of Schools Serving Students of Low Socio-Economic Status

Lavy

Ayuob

2019

Front. Psychol.

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The National Cancer Data Base Report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia

Diehl

Karnell

Menck

1999

Cancer

109

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BACKGROUND The natural history of chronic lymphocytic leukemia (CLL) is changing, although the reasons (potential changes in the disease's biology or in patterns in patient characteristics, treatment, or referral) are unclear. METHODS This report uses National Cancer Data Base (NCDB) data, which reflect a hospital‐based patient population from a broad spectrum of hospitals in the United States. Age, gender, race/ethnicity, income, treatment, overall survival, and relative survival were evaluated according to time period (1985–1990 and 1991–1995). Comparisons were made with U.S. population figures for 1990 and with series published over the last 70 years. RESULTS CLL comprised 22.6% of the 108,396 cases of leukemia in the data base. The risk of developing CLL increased progressively with age and did not plateau; the average age was 69.6 years. At the time of initial diagnosis, 60.5% of patients received no treatment (this proportion increased from 58.1% to 62.7% between the 2 time periods). Overall survival was 48.2% at 5 years and 22.5% at 10 years. The 5‐year relative survival was 69.5%, 72.2%, 63.1%, and 41.7% for age groups <40, 40–59, 60–79, and 80+ years, respectively; these rates indicated that CLL, and not comorbid disease, caused the greatest percentage of deaths. CONCLUSIONS The risk of developing CLL increases progressively with age without plateauing and is 2.8 times higher for older men than for older women. There is an increasing trend toward no treatment at the time of initial diagnosis. Long term overall survival of CLL patients is poor. CLL is a more fatal disease among older individuals because of the disease itself, not because of comorbid conditions. Cancer 1999;86:2684–92. © 1999 American Cancer Society.

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Diagnostic features and survival in typical and prolymphocytoid variants of chronic lymphocytic leukemia

Scott¹,

Stark²,

Head

et al. 1989

Hematological Oncology

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Diagnostic features were evaluated with regards to survival in 203 cases of typical and prolymphocytoid chronic lymphocytic leukemia. Excluding 27 (13 per cent) patients with second malignancies, survival analyses indicated that the prognostic factors with greatest significance were age at presentation (less than 65 years and 65 years or more: p = 0.0004), proportions of prolymphocytoid cells (less than 10 per cent and 10 per cent or more: p less than 0.0001 age corrected) and surface immunoglobulin (SIg) density (weak and more than weak: p = 0.001 age corrected). In contrast, sex, absolute numbers of prolymphocytoid cells, SIg light chain type and FMC7 expression were not prognostically significant. These observations suggest that the recognition and delineation of prolymphocytoid CLL variants by morphological and immunophenotypic criteria, although important in diagnostic terms, may have less relevance with respect to prognosis and patient management.

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Survival and prognostic factors in chronic lymphocytic leukemia

Cited by 15 publications

References 22 publications

Teachers’ Sense of Meaning Associations With Teacher Performance and Graduates’ Resilience: A Study of Schools Serving Students of Low Socio-Economic Status

Teachers’ Sense of Meaning Associations With Teacher Performance and Graduates’ Resilience: A Study of Schools Serving Students of Low Socio-Economic Status

The National Cancer Data Base Report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia

Diagnostic features and survival in typical and prolymphocytoid variants of chronic lymphocytic leukemia

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