Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma

Abstract

Background Soft-tissue sarcomas are rare malignancies that consist of many different histologic subtypes and arise in various locations in the body. In patients with lung metastases from retroperitoneal sarcomas, the long-term outcomes and prognostic factors are unknown. This study is a retrospective review of patients undergoing pulmonary metastasectomy for retroperitoneal sarcoma metastases at one institution, with the purpose of determining prognostic factors and clinical outcomes. Methods This is a single-center, retrospective cohort study of patients undergoing pulmonary metastasectomy for lung metastases from various sarcomas at Okayama University Hospital from January 2006 to December 2018. The Kaplan-Meier method and log-rank test were used for the analyses, and cut-off values of continuous variables were determined by a receiver operating characteristic curve analysis. Results Twenty-four patients underwent the first pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma in our hospital. Leiomyosarcoma was the most common histologic subtype of retroperitoneal sarcoma (79.2%, n = 19). Median overall survival was 49.9 months, and the 3-year and 5-year survival rates after the first pulmonary metastasectomy were 62.5% and 26.4% respectively. In univariate analysis, age ≥56 years, disease-free interval < 15 months, and size of metastasis (≥ 27 mm) were associated with poor survival. Conclusion Pulmonary metastasectomy can be considered as an effective management strategy in retroperitoneal sarcoma patients with lung metastases in appropriately selected cases, just as it is for other sarcomas.

Deep learning radiomics-based prediction model of metachronous distant metastasis following curative resection for retroperitoneal leiomyosarcoma: a bicentric study

“…Previous studies have reported that age, histological grading, pathological subtype, multifocality, and R0 resection are the main prognostic factors affecting DMFS following surgical resection in patients with RLS [ 14 , 30 , 31 ]. However, in the present study, the clinical model constructed based on the semantic imaging features identified as independent predictors of MDM in the univariate and multivariate analyses (tumor size > 10 cm) had an AUC of 0.511.…”

Pediatric retroperitoneal non-organ-originated malignancies: An analysis based on SEER database

“…Currently, studies on retroperitoneal primary tumors are focused more on adult patients [7][8][9][10][11] than pediatric patients, resulting in insufficient evidence for the pediatric retroperitoneal non-organ-originated malignancies. [12][13][14] Moreover, due to limited incidences and a small number of cases included in most studies, it is difficult to systematically summarize the clinicopathological features, treatment, prognosis, and prognostic analysis of pediatric patients with retroperitoneal tumors.…”