Survival and prognostic factors in patients undergoing the resection of solitary brain metastasis from non-small cell lung cancer: a retrospective cohort study

Xu, Min; Song, Kun; Zhou, Zhirui; Yu, Zhongbo; Lv, Yizheng; Xu, Huimin

doi:10.21037/jtd-22-1279

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Another possible reason might be that more efforts have been made in recent years aiming to improve the prognosis of brain. 8,[10][11][12][13][14][15][16][17][18][19] In this study, patients with liver metastasis had the poorest prognosis among all single-organ metastasis and were similar to those with MOM. Our results are consistent with the previous studies.…”

Section: Discussionmentioning

confidence: 88%

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The Incidence and Effect of Different Organ Metastasis on the Prognosis of NSCLC

Wei

et al. 2023

Thorac Cardiovasc Surg

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Objective: The aim of this study was to explore the effect of different organ metastasis on the prognosis of NSCLC. Methods: Patients with distant metastatic NSCLC were selected from Surveillance, Epidemiology, and End Results (SEER) database during 2016-2019. The incidence of different organ metastasis and their association with clinicopathological factors were explored. Overall survival (OS) and lung cancer-specific survival (LCSS) for metastatic NSCLC were calculated and multivariate Cox regression analysis was performed with a nomogram for OS being constructed based on Cox regression. Results: Total 26,210 patients with distant metastatic NSCLC were included in this study. Around 48.9% of the metastatic NSCLC were multiple-organ metastasis and bone was the most commonly involved organ (44.4%). For patients with single-organ metastasis, the prognosis for lung or distant LNs metastasis was better than others (with median OS of 15 and 16 months for lung and distant LNs metastasis respectively), and liver metastasis resulted in the worst prognosis with median OS of 8 months. A nomogram was constructed to visualize Cox regression model, along with the receiver operating characteristic (ROC) curve demonstrated good discrimination for the predictive model with 1- and 2-year area under the curve of ROC of 0.687 and 0.702, respectively. Conclusion: The prognosis of NSCLC patients with distant metastasis was poor. Liver metastasis results in the worst prognosis among the single organ metastasis. The nomogram developed based on the Cox regression model has provided a useful tool to estimate the probability of OS of the metastatic NSCLC.

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Section: Discussionmentioning

confidence: 88%

“…This might be the possible reason why patients' prognosis for those suffering from bone metastasis is poorer than those with brain metastasis. Another possible reason might be that more efforts have been made in recent years aiming to improve the prognosis of brain 8,[10][11][12][13][14][15][16][17][18][19] .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The Incidence and Effect of Different Organ Metastasis on the Prognosis of NSCLC

Wei

et al. 2023

Thorac Cardiovasc Surg

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Clinical features and prognostic factors of brain metastases from colorectal cancer: a single center experience

Zhao

Jin

2023

Int J Colorectal Dis

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Purpose: The study aimed to investigate the clinical characteristics, prognostic factors, survival times, and therapy outcomes of brain metastases (BM) from colorectal cancer (CRC).Methods: The clinical characteristics of 25 patients with BM from CRC were retrospectively analyzed. The time of the occurrence of BM after diagnosis of CRC was recorded. Meanwhile, the time from the occurrence of lung, bone, liver, and other extracranial metastases to the occurrence of BM was also recorded. We evaluate the time factors affecting the length of the occurrence of BM and the potential prognostic factors after BM diagnosis. The in uences of patients undergoing surgery-based comprehensive treatment, radiotherapy-based comprehensive treatment, and co-medication were also assessed.Results: In patients with BM from CRC, lung metastases (13/25) occurred at a higher frequency than liver metastases (8/25) and bone metastases (6/25). The median time to the development of BM was much shorter (3.7 vs. 25.3 months, p=0.027), with the brain being the origin site for the metastasis. The median overall survival reached 9.9 months. The interval between diagnosis of BM and bone, liver, and lung metastasis remains 3, 6.5, and 11 months, respectively. The brain lesions of patients with BM alone had higher rates in supratentorial (88.9%), while those with extracranial metastasis had a 62.5% incidence of infratentorial metastasis. The difference was statistically signi cant (p<0.05). The time of occurrence of BM in patients aged 67 years and younger was 16.1 and 30.1 months, respectively. The differences between them were statistically signi cant (p=0.043). The BM time for left-and right-sided colon cancer were 26.5 and 7.8 months, representing a statistically signi cant difference (p=0.015). The time to onset of BM for patients with and without the resection of primary lesions was 25.4 and 4.5 months.Statistically signi cant differences are shown (p=0.007). Univariate analysis demonstrated that the prognosis of patients was related to the KPS score, the number of BM, treatment methods, and the occurrence of lung metastasis (p<0.05). The multivariate analysis revealed that the treatment modality and lung metastasis were independent prognostic factors for CRC patients with BM. Right-sided CRC patients with BM have poor prognosis (8.1vs10.2months, p=0.31). Although median survival time was not signi cantly different between patients with and without bevacizumab combination therapy, bevacizumab therapy is associated with a better survival time (9.9 vs. 7.1 months, p = 0.27).Conclusion: Patients with left-sided CRC, especially those with lung metastases, are prone to brain metastases, and patients with brain metastases as the rst metastatic site have a higher rate of supratentorial metastases. Young patients with right hemicolon cancer, and patients who have not undergone primary lesion resection have a shorter time for the occurrence of BM. Patients with colorectal lung metastases, especially those young with right-sided CRC, require close imagi...

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Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales

Botta¹,

Rocha²,

Souza³

et al. 2023

Neurosurg Rev

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Survival and prognostic factors in patients undergoing the resection of solitary brain metastasis from non-small cell lung cancer: a retrospective cohort study

Cited by 4 publications

References 35 publications

The Incidence and Effect of Different Organ Metastasis on the Prognosis of NSCLC

The Incidence and Effect of Different Organ Metastasis on the Prognosis of NSCLC

Clinical features and prognostic factors of brain metastases from colorectal cancer: a single center experience

Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales

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