Survival and prognostic factors in women treated for epithelial ovarian cancer in western region of Saudi Arabia

Abstract

Objectives: To assess survival and prognostic factors among women with epithelial ovarian cancer in Western Saudi Arabia.Methods: A retrospective cohort study was carried out between October 2000 and May 2018, reviewing clinical and pathology data of all women who underwent staging or debulking surgery for epithelial ovarian cancer. Analysis of disease-free survival (DFS), overall survivals (OS) and the associated factors used Kaplan-Meier method in addition to cox multivariate regression.Results: A total of 144 patients were included (median age=49.5 years), with a median follow-up time was Original Article3.4 years. Majority (59.7%) of the patients were diagnosed at an advanced stage (III or IV). The mean (95% CI) DFS was 82.3 (67.8-96.8) months, OS was 96.2 (81.3-111.2) months, and the 5-year survival rate was estimated as 38.9%. Univariate analysis showed that older age, clear cell or papillary carcinoma subtypes, serous type, advanced International Federation of Gynecology and Obstetrics (FIGO) stage and the presence of residual disease were associated with poorer DFS and OS (log rank <0.05). Cox regression showed FIGO stage and residual disease >1cm as the strongest prognostic factors independently associated with DFS and OS. Conclusion:Improving early diagnosis and achieving optimal cytoreduction are the most critical challenges to achieve significant positive impact on survival of women with epithelial ovarian cancer.

Nurses, Knowledge and Attitude regarding Cervical Cancer Screening in Erbil City

“…In a cross-sectional study by Ayub in Pakistan among nursing staff, their ages were between 25-34, and more than two-thirds of nurses (72%) were married [18]. Another result agrees with the present study, which was done in an institution in rural India by Shekhar among nursing staff their age was between (20)(21)(22)(23)(24)(25)(26)(27)(28)(29) and most of them (86.6%) were married [19]. The result disagrees with a study done among doctors and nurses indicating the highest percentage of participants their ages were between (21 -30) years old (32.9%) [20].Another that two-thirds of participants (67.9%) were married and their ages were between 41-50 years is also in disagreement with the present study [21].…”

“…The present study has shown more than half (53.3%) of respondents had good knowledge of cervical screening. A similar investigation was reported by Sait [25]. In our study, more than one-third (48.6%) of participants knew that screening should begin at 25 years or 3 years after starting sexual activity whichever is earlier.…”

Hysterectomy Profile in King Edward Memorial Hospital, Pune, India: Indications, Routes of Surgery, and Complications

“…Vaginal or abdominal routes have been used for hysterectomy procedures conventionally. Laparoscopic hysterectomy is one of the minimal access methods that are being used more often for hysterectomies [8,9].…”

Awareness Level About Cervical Cancer, Human Papillomavirus (HPV) and Corresponding Vaccine Among Women Living in the Western Region of Saudi Arabia

“…For the last 10 years, the HPV vaccine has been provided in the KSA and is accessible in large hospitals with or without monetary charges [ 11 ]. In KSA, the uptake of the HPV vaccine is still low [ 12 , 13 ], which is attributed to a variety of reasons, including an inadequate understanding of HPV and its connection to cervical cancer, a lack of recognition of the HPV vaccination, and the belief that HPV is a sensitive topic in the conservative Saudi community [ 14 , 15 ].…”