Survival and prognostic factors in patients with localised cutaneous melanoma observed between 1980 and 1991 at the Istituto Dermopatico dell'Immacolata in Rome, Italy

Prognostic evaluation of cutaneous malignant melanoma: A clinicopathologic and immunohistochemical study

“…Invasiveness of cutaneous melanoma expressed as a tumor thickness or a level of invasion is the powerful prognostic indicator in malignant melanoma [1][2][3][4]8,34,39]. The present study has confirmed the prognostic importance of Breslow thickness and Clark level; however, only Breslow thickness was an independent predictor for overall survival.…”

“…Prognostic value of commonly used clinical and morphological parameters in cutaneous malignant melanoma is still an open problem and only tumor thickness and stage of the disease seem to be independent indicators of the clinical outcome [1][2][3][4][5][6][7][8][9][10][11][12][13]. Some results point to markers of proliferative activity [14][15][16][17][18][19][20][21] and expression of p53 protein [14,17,[22][23][24][25][26] as variables of prognostic value.…”

Guidelines of care for the management of primary cutaneous melanoma

“…of metastatic nodes and presence or absence of intralymphatic metastases (in transit or satellite) Note: N1-3 and a-c subcategories assigned as shown below: J AM ACAD DERMATOL VOLUME 65, NUMBER 5 the lesion must be included. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] The clinical information in the pathology report should contain the type of surgical procedure performed (ie, biopsy intenteexcisional or incisional) and size of the lesion. Additional optional, but desirable, clinical information include ABCDE criteria, dermatoscopic features, a clinical photograph, and the presence or absence of macroscopic satellitosis.…”

“…There is strong evidence to support that 3 histologic features are the most important characteristics of the primary tumor to predict outcome. 6,[20][21][22][23]25,26,[30][31][32][34][35][36][37][38][39][40] (1) Maximum tumor (Breslow) thickness is measured from the granular layer of the overlying epidermis or base of a superficial ulceration to the deepest malignant cells invading dermis to the nearest 0.1 mm, not including deeper adventitial extension. Microsatellitosis should not be included in this measurement, but commented on separately.…”

Prognostic factors for cutaneous malignant melanoma in Vaud, Switzerland

“…Similar trends toward earlier detection and improved survival were observed in Australia (Burton et al, 1993;Heenan et al, 1991;Roder et al, 1995), Scotland (Herd et al, 1995;MacKie et al, 1997), Denmark (Drzewiecki et al, 1990) and Switzerland (Levi et al, 1995). However, changes in the diagnosis of the disease seem unlikely to totally explain the rise in incidence (Horn-Ross et al, 1991;van der Esch et al, 1991), and little improvement in survival has been observed between cases diagnosed in 1973 and in 1984 in Connecticut (Berwick et al, 1994.Prognosis from melanoma is better at younger ages and in females (Corona et al, 1994;Heenan et al, 1991; Mäsbäck et al, 1994 Mäsbäck et al, , 1997Roder et al, 1995; Thörn et al, 1996) and varies according to anatomic site (i.e., better in melanomas of the limbs, MacKie et al, 1995MacKie et al, , 1997, but the relationship between tumor and host characteristics is not well quantified (Corona et al, 1994; Thörn et al, 1996).Thus, we considered, by means of a multivariate approach, trends in survival from cutaneous malignant melanoma in relation to patients' and tumors' characteristics, using data from the Cancer Registry of the Swiss Canton of Vaud, a population particularly well surveilled with reference to skin neoplasms (Levi et al, 1988(Levi et al, , 1995. …”